Skip to Main content Skip to Navigation
Journal articles

Molecular and cellular response of the most extensively used rodent glioma models to radiation and/or cisplatin.

Abstract : Purpose Anti-glioma strategies are generally based on trials involving rodent models whose choice remains based on proliferative capacity and availability. Recently, our group obtained the most protracted survival of rats bearing F98 gliomas by combining synchrotron X-rays and intracerebral cisplatin injection (Biston et al., Cancer Res, 64:2317-2323, 2004). The response to such treatment was suggested to be dependent on BRCA1, a tumour suppressor known to be involved in the response to radiation and cisplatin. In order to verify the impact of BRCA1 functionality upon success of anti-glioma trials, radiobiological features and BRCA1-dependent stress signalling were investigated in the most extensively used rodent glioma models. Methods Cell death pathways, cell cycle arrests, DNA repair and stress signalling were evaluated in response to radiation and cisplatin in C6, 9L and F98 models. Results Rodent glioma models showed a large spectrum of cellular radiation response. Surprisingly, BRCA1 was found to be functionally impaired in C6 and F98 favouring genomic instability, tumour heterogeneity and tolerance of unrepaired DNA damage. Significance Our findings strengthened the importance of the choice of the glioma model on genetic and radiobiological bases, inasmuch as all these rat glioma models are induced by nitrosourea-mediated mutagenesis that may favour specific gene mutations. Particularly, BRCA1 status may condition the response to anti-glioma treatments. Furthermore, since BRCA1 acts as a tumour suppressor in a number of malignancies, our findings raise also the question of the implication of BRCA1 in brain tumours formation.
Document type :
Journal articles
Complete list of metadatas

Cited literature [37 references]  Display  Hide  Download

https://www.hal.inserm.fr/inserm-00166124
Contributor : Nicolas Foray <>
Submitted on : Wednesday, August 1, 2007 - 2:40:32 PM
Last modification on : Friday, November 6, 2020 - 3:49:24 AM
Long-term archiving on: : Friday, November 25, 2016 - 5:09:08 PM

File

 Restricted access
To satisfy the distribution rights of the publisher, the document is embargoed until : jamais

Please log in to resquest access to the document

Identifiers

Collections

IRSN | UGA

Citation

Zuzana Bencokova, Laurianne Pauron, Clément Devic, Aurélie Joubert, Jérôme Gastaldo, et al.. Molecular and cellular response of the most extensively used rodent glioma models to radiation and/or cisplatin.. Journal of Neuro-Oncology, Springer Verlag, 2008, 86 (1), pp.13-21. ⟨10.1007/s11060-007-9433-0⟩. ⟨inserm-00166124⟩

Share

Metrics

Record views

222