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Defective osteoblast function in ICAP-1-deficient mice.: ICAP-1 promotes osteogenesis

Abstract : The integrin receptor family plays important roles in cell-to-cell and cell-to-extracellular matrix interactions through the recruitment of accessory molecules. One of them, the integrin cytoplasmic domain-associated protein-1 (ICAP-1; also known as ITGB1BP1), specifically interacts with the cytoplasmic domain of the beta(1) integrin subunit and negatively regulates its function in vitro. To address the role of ICAP-1 in vivo, we ablated the Icap-1 gene in mice. We report an unexpected role of ICAP-1 in osteoblast function during bone development. Icap-1-deficient mice suffer from reduced osteoblast proliferation and delayed bone mineralization, resulting in the retarded formation of bone sutures. In vitro studies reveal that primary and immortalized Icap-1-null osteoblasts display enhanced adhesion and spreading on extracellular matrix substrates, probably owing to an increase in beta(1) integrin activation. Finally, we provide evidence that ICAP-1 promotes differentiation of osteoprogenitors by supporting their condensation through modulating the integrin high affinity state.
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Contributor : Daniel Bouvard Connect in order to contact the contributor
Submitted on : Thursday, November 19, 2009 - 8:33:34 AM
Last modification on : Thursday, July 28, 2022 - 3:34:46 PM
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Daniel Dysad Erl 3148 Bouvard, Attila Aszodi, Günter Kostka, Marc R. Block, Corinne Albiges-Rizo, et al.. Defective osteoblast function in ICAP-1-deficient mice.: ICAP-1 promotes osteogenesis. Development (Cambridge, England), Company of Biologists, 2007, 134 (14), pp.2615-25. ⟨10.1242/dev.000877⟩. ⟨inserm-00166116⟩



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