Skip to Main content Skip to Navigation
Journal articles

Hybrid composites of calcium phosphate granules, fibrin glue, and bone marrow for skeletal repair.

Abstract : Synthetic bone substitutes, such as calcium phosphate ceramics, give good results in clinical applications. In order to adapt to surgical sites, bioceramics come in the form of blocks or granules, and are either dense or porous. Combining these bioceramics with fibrin glue provides a mouldable and self-hardening composite biomaterial with the biochemical properties of each component. Critical-sized defects in the femoral condyle of rabbits were filled with TricOs/fibrin glue/bone marrow hybrid/composite material. The TricOs granules (1-2 mm) were composed of hydroxyapatite and beta tricalcium phosphate (60/40 in weight). The fibrin glue was composed of fibrinogen, thrombin and other biological factors and mixed with MBCP granules either simultaneously or sequentially. Bone marrow was also added to the MBCP/fibrin composite prior to filling the defects. After 3, 6, 12, and 24 weeks of implantation, the newly-formed bone was analysed with histology, histomorphometry and mechanical tests. The newly-formed bone had grown centripetally. Simultaneous application of fibrin glue showed better results for mechanical properties than sequential application after 6 weeks. Around 40% of bone had formed after 24 weeks in the three groups. Although the addition of bone marrow did not improve bone formation, the MBCP/fibrin material could be used in clinical bone filling applications.
Document type :
Journal articles
Complete list of metadata
Contributor : Pierre Layrolle Connect in order to contact the contributor
Submitted on : Tuesday, July 31, 2007 - 3:56:28 PM
Last modification on : Wednesday, April 27, 2022 - 4:00:23 AM

Links full text



Damien Le Nihouannen, Eric Goyenvalle, Eric Aguado, Paul Pilet, Melitta Bilban, et al.. Hybrid composites of calcium phosphate granules, fibrin glue, and bone marrow for skeletal repair.. Journal of Biomedical Materials Research Part A, Wiley, 2007, 81 (2), pp.399-408. ⟨10.1002/jbm.a.31058⟩. ⟨inserm-00166075⟩



Record views