Skip to Main content Skip to Navigation
Journal articles

Tachykinin regulation of cholinergic transmission in the limbic/prefrontal territory of the rat dorsal striatum: implication of new neurokinine 1-sensitive receptor binding site and interaction with enkephalin/mu opioid receptor transmission.

Sylvie Pérez 1 Adrienne Tierney 1 Jean-Michel Deniau 1 Marie-Louise Kemel 1, *
* Corresponding author
1 Dynamique et physiopathologie des réseaux neuronaux
CIRB - Centre interdisciplinaire de recherche en biologie, INSERM - Institut National de la Santé et de la Recherche Médicale : U667, UPMC - Université Pierre et Marie Curie - Paris 6
Abstract : The tachykinin neurokinin 1 receptors (NK(1)Rs) regulation of acetylcholine release and its interaction with the enkephalin/mu opioid receptors (MORs) transmission was investigated in the limbic/prefrontal (PF) territory of the dorsal striatum. Using double immunohistochemistry, we first showed that in this territory, cholinergic interneurons contain tachykinin NK(1)Rs and co-express MORs in the last part of the light period (afternoon). In slices of the striatal limbic/PF territory, following suppression of the dopaminergic inhibitory control of acetylcholine release, application of the tachykinin NK(1)R antagonist, SSR240600, markedly reduced the NMDA-induced acetylcholine release in the morning but not in the afternoon when the enkephalin/MOR regulation is operational. In the afternoon, the NK(1)R antagonist response required the suppression of the enkephalin/MOR inhibitory control of acetylcholine release by betafunaltrexamine. The pharmacological profile of the tachykinin NK(1)R regulation tested by application of the receptor agonists [[Pro(9)]substance P, neurokinin A, neuropeptide K, and substance P(6-11)] and antagonists (SSR240600, GR205171, GR82334, and RP67580) indicated that the subtype of tachykinin NK(1)R implicated are the new NK(1)-sensitive receptor binding site. Therefore, in the limbic/PF territory of the dorsal striatum, endogenous tachykinin facilitates acetylcholine release via a tachykinin NK(1)R subtype. In the afternoon, the tachykinin/NK(1)R and the enkephalin/MOR transmissions interact to control cholinergic transmission.
Complete list of metadatas

https://www.hal.inserm.fr/inserm-00165788
Contributor : Sandrine Mouret <>
Submitted on : Friday, May 23, 2014 - 10:26:45 AM
Last modification on : Wednesday, September 23, 2020 - 4:32:15 AM
Long-term archiving on: : Saturday, August 23, 2014 - 10:35:42 AM

Identifiers

Collections

Citation

Sylvie Pérez, Adrienne Tierney, Jean-Michel Deniau, Marie-Louise Kemel. Tachykinin regulation of cholinergic transmission in the limbic/prefrontal territory of the rat dorsal striatum: implication of new neurokinine 1-sensitive receptor binding site and interaction with enkephalin/mu opioid receptor transmission.. Journal of Neurochemistry, Wiley, 2007, 103 (6), pp.2153-63. ⟨10.1111/j.1471-4159.2007.04944.x⟩. ⟨inserm-00165788⟩

Share

Metrics

Record views

379

Files downloads

478