Skip to Main content Skip to Navigation
Journal articles

Influence of gender on the outcome of severe sepsis: a reappraisal.

Abstract : BACKGROUND: The influence of gender on survival of patients with severe sepsis is unclear. Earlier studies suggested better survival in women, possibly related to the sex-steroid profile. METHODS: To investigate whether mortality from severe sepsis was higher in men than in women and whether the difference varied with menopausal status, we studied 1,692 patients with severe sepsis included in the OutcomeRea database over an 8-year period. We conducted a nested case-control study, accurately matching men and women on three criteria: a death propensity score, age, and center. Subgroup analyses were performed on individuals 50 years old (men vs postmenopausal women). RESULTS: We matched 1,000 men to 608 women with severe sepsis before and after adjustment for confounding factors (ie, chronic respiratory failure; metastatic cancer; immunocompromised status; emergency surgery, acute respiratory failure, and shock at admission; urinary tract infection; and type of microorganism). Overall hospital mortality was significantly lower in women (adjusted odds ratio [OR], 0.75; 95% confidence interval [CI], 0.57 to 0.97; p = 0.02). In the group > 50 years old (481 women, 778 men), hospital mortality was significantly lower in women (OR, 0.69; 95% CI, 0.52 to 0.93; p = 0.014). Hospital mortality was not significantly different between men and women in the younger group (127 women, 222 men) [OR, 1.01; 95% CI, 0.52 to 1.97; p = 0.98]. Level of care, as assessed using the nine equivalents of nursing manpower use score, was identical in men and women. CONCLUSIONS: Among individuals > 50 years old with severe sepsis, women have a lower risk of hospital mortality than men.
Document type :
Journal articles
Complete list of metadata

Cited literature [11 references]  Display  Hide  Download
Contributor : Jean-Francois Timsit <>
Submitted on : Friday, July 20, 2007 - 1:36:03 PM
Last modification on : Friday, November 6, 2020 - 3:52:36 AM
Long-term archiving on: : Friday, November 25, 2016 - 6:16:52 PM


 Restricted access
To satisfy the distribution rights of the publisher, the document is embargoed until : jamais

Please log in to resquest access to the document



Christophe Adrie, Elie Azoulay, Adrien Francais, Christophe Chlec'H, Loic Darques, et al.. Influence of gender on the outcome of severe sepsis: a reappraisal.. Chest, American College of Chest Physicians, 2007, 132 (6), pp.1786-93. ⟨10.1378/chest.07-0420⟩. ⟨inserm-00164438⟩



Record views