B. Kjer, H. Eiberg, P. Kjer, and T. Rosenberg, Dominant optic atrophy mapped to chromosome 3q region, Acta Ophthalmologica Scandinavica, vol.359, issue.Suppl 54, pp.3-7, 1996.
DOI : 10.1111/j.1600-0420.1996.tb00672.x

P. B. Johnston, R. N. Gaster, V. C. Smith, and R. C. Tripathi, A Clinicopathologic Study of Autosomal Dominant Optic Atrophy, American Journal of Ophthalmology, vol.88, issue.5, pp.868-875, 1979.
DOI : 10.1016/0002-9394(79)90565-8

C. S. Hoyt, Autosomal Dominant Optic Atrophy, Ophthalmology, vol.87, issue.3, pp.245-251, 1980.
DOI : 10.1016/S0161-6420(80)35247-0

M. Votruba, A. T. Moore, and S. S. Bhattacharya, Clinical features, molecular genetics, and pathophysiology of dominant optic atrophy., Journal of Medical Genetics, vol.35, issue.10, pp.793-800, 1998.
DOI : 10.1136/jmg.35.10.793

P. Kjer, O. A. Jensen, and L. Klinken, HISTOPATHOLOGY OF EYE, OPTIC NERVE AND BRAIN IN A CASE OF DOMINANT OPTIC ATROPHY, Acta Ophthalmologica, vol.86, issue.2, pp.300-312, 1983.
DOI : 10.1111/j.1755-3768.1983.tb01424.x

V. Carelli, M. Rugolo, G. Sgarbi, A. Ghelli, C. Zanna et al., Bioenergetics shapes cellular death pathways in Leber's hereditary optic neuropathy: a model of mitochondrial neurodegeneration, Biochimica et Biophysica Acta (BBA) - Bioenergetics, vol.1658, issue.1-2, pp.172-179, 2004.
DOI : 10.1016/j.bbabio.2004.05.009

H. Eiberg, B. Kjer, P. Kjer, and T. Rosenberg, Dominant optic atrophy (OPA1) mapped to chromosome 3q region. I. Linkage analysis, Human Molecular Genetics, vol.3, issue.6, pp.977-980, 1994.
DOI : 10.1093/hmg/3.6.977

J. B. Kerrison, V. J. Arnould, J. M. Ferraz-sallum, M. R. Vagefi, M. M. Barmada et al., Genetic Heterogeneity of Dominant Optic Atrophy, Kjer Type, Archives of Ophthalmology, vol.117, issue.6, pp.805-810, 1999.
DOI : 10.1001/archopht.117.6.805

P. Reynier, P. Amati-bonneau, C. Verny, A. Olichon, G. Simard et al., OPA3 gene mutations responsible for autosomal dominant optic atrophy and cataract, Journal of Medical Genetics, vol.41, issue.9, pp.110-121, 2004.
DOI : 10.1136/jmg.2003.016576

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1735897

C. Alexander, M. Votruba, U. E. Pesch, D. L. Thiselton, S. Mayer et al., OPA1, encoding a dynamin-related GTPase, is mutated in autosomal dominant optic atrophy linked to chromosome 3q28, Nature Genetics, vol.132, issue.2, pp.211-215, 2000.
DOI : 10.1146/annurev.bi.50.070181.002025

C. Delettre, J. M. Griffoin, J. Kaplan, H. Dollfus, B. Lorenz et al., Mutation spectrum and splicing variants in the OPA1 gene, Human Genetics, vol.109, issue.6, pp.584-591, 2001.
DOI : 10.1007/s00439-001-0633-y

J. E. Hinshaw, Dynamin and Its Role in Membrane Fission, Annual Review of Cell and Developmental Biology, vol.16, issue.1, pp.483-519, 2000.
DOI : 10.1146/annurev.cellbio.16.1.483

G. J. Praefcke and H. T. Mcmahon, The dynamin superfamily: universal membrane tubulation and fission molecules?, Nature Reviews Molecular Cell Biology, vol.5, issue.2, pp.133-147, 2004.
DOI : 10.1038/nrm1313

T. Misaka, T. Miyashita, and Y. Kubo, Primary Structure of a Dynamin-related Mouse Mitochondrial GTPase and Its Distribution in Brain, Subcellular Localization, and Effect on Mitochondrial Morphology, Journal of Biological Chemistry, vol.277, issue.18, pp.15834-15842, 2002.
DOI : 10.1074/jbc.M109260200

M. Satoh, T. Hamamoto, N. Seo, Y. Kagawa, and H. Endo, Differential sublocalization of the dynamin-related protein OPA1 isoforms in mitochondria, Biochemical and Biophysical Research Communications, vol.300, issue.2, pp.482-493, 2003.
DOI : 10.1016/S0006-291X(02)02874-7

L. Griparic, N. N. Van-der-wel, I. J. Orozco, P. J. Peters, and A. M. Van-der-bliek, Loss of the Intermembrane Space Protein Mgm1/OPA1 Induces Swelling and Localized Constrictions along the Lengths of Mitochondria, Journal of Biological Chemistry, vol.279, issue.18, pp.18792-18798, 2004.
DOI : 10.1074/jbc.M400920200

E. D. Wong, J. A. Wagner, S. V. Scott, V. Okreglak, T. J. Holewinske et al., The intramitochondrial dynamin-related GTPase, Mgm1p, is a component of a protein complex that mediates mitochondrial fusion, The Journal of Cell Biology, vol.114, issue.3, pp.303-311, 2003.
DOI : 10.1038/ncb1001-922

H. Sesaki, S. M. Southard, M. P. Yaffe, and R. E. Jensen, Mgm1p, a Dynamin-related GTPase, Is Essential for Fusion of the Mitochondrial Outer Membrane, Molecular Biology of the Cell, vol.14, issue.6, pp.2342-2356, 2003.
DOI : 10.1091/mbc.E02-12-0788

S. V. Scott, A. Cassidy-stone, S. L. Meeusen, and J. Nunnari, Staying in aerobic shape: how the structural integrity of mitochondria and mitochondrial DNA is maintained, Current Opinion in Cell Biology, vol.15, issue.4, pp.482-488, 2003.
DOI : 10.1016/S0955-0674(03)00070-X

D. A. Rube and A. M. Van-der-bliek, Mitochondrial morphology is dynamic and varied, Molecular and Cellular Biochemistry, vol.256, issue.1/2, pp.331-339, 2004.
DOI : 10.1023/B:MCBI.0000009879.01256.f6

A. Olichon, L. Baricault, N. Gas, E. Guillou, A. Valette et al., Loss of OPA1 Perturbates the Mitochondrial Inner Membrane Structure and Integrity, Leading to Cytochrome c Release and Apoptosis, Journal of Biological Chemistry, vol.278, issue.10, pp.7743-7746, 2003.
DOI : 10.1074/jbc.C200677200

Y. J. Lee, S. Y. Jeong, M. Karbowski, C. L. Smith, Y. et al., Roles of the Mammalian Mitochondrial Fission and Fusion Mediators Fis1, Drp1, and Opa1 in Apoptosis, Molecular Biology of the Cell, vol.15, issue.11, pp.5001-5011, 2004.
DOI : 10.1091/mbc.E04-04-0294

M. Ferre, P. Amati-bonneau, Y. Tourmen, Y. Malthiery, and P. Reynier, mutations, Human Mutation, vol.47, issue.5, pp.423-428, 2005.
DOI : 10.1002/humu.20161

URL : https://hal.archives-ouvertes.fr/inserm-00372261

H. R. Bourne, D. A. Sanders, and F. Mccormick, The GTPase superfamily: conserved structure and molecular mechanism, Nature, vol.349, issue.6305, pp.117-127, 1991.
DOI : 10.1038/349117a0

B. Marks, M. H. Stowell, Y. Vallis, I. G. Mills, A. Gibson et al., GTPase activity of dynamin and resulting conformation change are essential for endocytosis, Nature, vol.17, issue.6825, pp.231-235, 1999.
DOI : 10.1038/35065645

H. Damke, D. D. Binns, H. Ueda, S. L. Schmid, and T. Baba, Dynamin GTPase Domain Mutants Block Endocytic Vesicle Formation at Morphologically Distinct Stages, Molecular Biology of the Cell, vol.12, issue.9, pp.2578-2589, 2001.
DOI : 10.1091/mbc.12.9.2578

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC59696

S. Frank, B. Gaume, E. S. Bergmann-leitner, W. W. Leitner, E. G. Robert et al., The Role of Dynamin-Related Protein 1, a Mediator of Mitochondrial Fission, in Apoptosis, Developmental Cell, vol.1, issue.4, pp.515-525, 2001.
DOI : 10.1016/S1534-5807(01)00055-7

URL : https://hal.archives-ouvertes.fr/hal-00153696

D. I. James, P. A. Parone, Y. Mattenberger, and J. C. Martinou, hFis1, a Novel Component of the Mammalian Mitochondrial Fission Machinery, Journal of Biological Chemistry, vol.278, issue.38, pp.36373-36379, 2003.
DOI : 10.1074/jbc.M303758200

R. Sugioka, S. Shimizu, and Y. Tsujimoto, Fzo1, a Protein Involved in Mitochondrial Fusion, Inhibits Apoptosis, Journal of Biological Chemistry, vol.279, issue.50, pp.52726-52734, 2004.
DOI : 10.1074/jbc.M408910200

M. Karbowski, Y. , and R. J. , Dynamics of mitochondrial morphology in healthy cells and during apoptosis, Cell Death and Differentiation, vol.10, issue.8, pp.870-880, 2003.
DOI : 10.1038/sj.cdd.4401260

J. L. Perfettini, T. Roumier, and G. Kroemer, Mitochondrial fusion and fission in the control of apoptosis, Trends in Cell Biology, vol.15, issue.4, pp.179-183, 2005.
DOI : 10.1016/j.tcb.2005.02.005

S. R. Danielson, A. Wong, V. Carelli, A. Martinuzzi, A. H. Schapira et al., Cells Bearing Mutations Causing Leber's Hereditary Optic Neuropathy Are Sensitized to Fas-induced Apoptosis, Journal of Biological Chemistry, vol.277, issue.8, pp.5810-5815, 2002.
DOI : 10.1074/jbc.M110119200

A. Ghelli, C. Zanna, A. M. Porcelli, A. H. Schapira, A. Martinuzzi et al., Leber's Hereditary Optic Neuropathy (LHON) Pathogenic Mutations Induce Mitochondrial-dependent Apoptotic Death in Transmitochondrial Cells Incubated with Galactose Medium, Journal of Biological Chemistry, vol.278, issue.6, pp.4145-4150, 2003.
DOI : 10.1074/jbc.M210285200

C. Zanna, A. Ghelli, A. M. Porcelli, V. Carelli, A. Martinuzzi et al., Apoptotic Cell Death of Cybrid Cells Bearing Leber's Hereditary Optic Neuropathy Mutations Is Caspase Independent, Annals of the New York Academy of Sciences, vol.402, issue.1, pp.213-217, 2003.
DOI : 10.1196/annals.1299.037

C. Battisti, P. Formichi, E. Cardaioli, S. Bianchi, P. Mangiavacchi et al., Cell response to oxidative stress induced apoptosis in patients with Leber's hereditary optic neuropathy, Journal of Neurology, Neurosurgery & Psychiatry, vol.75, issue.12, pp.1731-1736, 2004.
DOI : 10.1136/jnnp.2003.024372

V. Carelli, F. N. Ross-cisneros, and A. A. Sadun, Mitochondrial dysfunction as a cause of optic neuropathies, Progress in Retinal and Eye Research, vol.23, issue.1, pp.53-89, 2004.
DOI : 10.1016/j.preteyeres.2003.10.003

M. Votruba, Molecular genetic basis of primary inherited optic neuropathies, Eye, vol.18, issue.11, pp.1126-1132, 2004.
DOI : 10.1038/sj.eye.6701570

S. Zuchner, I. V. Mersiyanova, M. Muglia, N. Bissar-tadmouri, J. Rochelle et al., Mutations in the mitochondrial GTPase mitofusin 2 cause Charcot-Marie-Tooth neuropathy type 2A, Nature Genetics, vol.8, issue.5, pp.449-451, 2004.
DOI : 10.1083/jcb.200209124

Z. Li, K. Okamoto, Y. Hayashi, and M. Sheng, The Importance of Dendritic Mitochondria in the Morphogenesis and Plasticity of Spines and Synapses, Cell, vol.119, issue.6, pp.873-887, 2004.
DOI : 10.1016/j.cell.2004.11.003

R. Lodi, C. Tonon, M. L. Valentino, S. Iotti, V. Clementi et al., Deficit of in vivo mitochondrial ATP production in OPA1-related dominant optic atrophy, Annals of Neurology, vol.278, issue.5, pp.719-723, 2004.
DOI : 10.1002/ana.20278

J. Y. Kim, J. M. Hwang, H. S. Ko, M. W. Seong, B. J. Park et al., Mitochondrial DNA content is decreased in autosomal dominant optic atrophy, Neurology, vol.64, issue.6, pp.966-972, 2005.
DOI : 10.1212/01.WNL.0000157282.76715.B1