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Global distribution of Panton-Valentine leukocidin--positive methicillin-resistant Staphylococcus aureus, 2006.

Abstract : We determined the agr type, multilocus sequence type, protein A gene type (spa typing), toxin gene profile, and antimicrobial drug resistance profile of 469 isolates of Panton-Valentine leukocidin-positive community-acquired methicillin-resistant Staphylococcus aureus isolates (PVL-positive CA-MRSA). The isolates had been collected from around the world from 1999 through 2005 by the French National Reference Center for Staphylococci. We found that some continent-specific clones described in 2003, such as clone ST8, have now spread all over the world. Likewise, some PVL-positive CA-MRSA have spread to several countries on various continents. New clones have emerged (e.g., ST377) on new genetic backgrounds. PVL-positive CA-MRSA that were usually susceptible to most antistaphylococcal antimicrobial agents have acquired new resistance determinants (e.g., to gentamicin) in certain countries. The major trait shared by all these clones is a short staphylococcal chromosomal cassette mec element of type IV or V.
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Contributor : Anne Tristan <>
Submitted on : Monday, June 25, 2007 - 5:28:32 PM
Last modification on : Monday, January 13, 2020 - 5:08:05 PM
Long-term archiving on: : Thursday, April 8, 2010 - 9:31:31 PM

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Anne Tristan, Michèle Bes, Hélène Meugnier, Gérard Lina, Bülent Bozdogan, et al.. Global distribution of Panton-Valentine leukocidin--positive methicillin-resistant Staphylococcus aureus, 2006.. Emerging Infectious Diseases, Centers for Disease Control and Prevention, 2007, 13 (4), pp.594-600. ⟨10.3201/eid1304.061316⟩. ⟨inserm-00157272⟩

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