N. Ferrara and K. Alitalo, Clinical application of angiogenic growth factors and their inhibitors, Nature Medicine, vol.5, issue.12, pp.1359-64, 1999.
DOI : 10.1038/70928

C. Robinson and S. Stringer, The splice variants of vascular endothelial growth factor (VEGF) and their receptors, J Cell Sci, vol.114, pp.853-65, 2001.

D. Shweiki, A. Itin, D. Soffer, and E. Keshet, Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis, Nature, vol.359, issue.6398, pp.843-848, 1992.
DOI : 10.1038/359843a0

S. Grugel, G. Finkenzeller, K. Weindel, B. Barleon, and D. Marme, Both v-Ha-Ras and v-Raf Stimulate Expression of the Vascular Endothelial Growth Factor in NIH 3T3 Cells, Journal of Biological Chemistry, vol.270, issue.43, pp.25915-25924, 1995.
DOI : 10.1074/jbc.270.43.25915

L. Pertovaara, A. Kaipainen, T. Mustonen, A. Orpana, N. Ferrara et al., Vascular endothelial growth factor is induced in response to transforming growth factor-in fibroblastic and epithelial cells, J Biol Chem, vol.269, pp.6271-6275, 1994.

R. Warren, H. Yuan, M. Matli, N. Ferrara, and D. Donner, Induction of vascular endothelial growth factor by insulin-like growth factor 1 in colorectal carcinoma, J Biol Chem, vol.271, pp.29483-29491, 1996.

J. Ruohola, E. Valve, M. Karkkainen, V. Joukov, K. Alitalo et al., Vascular endothelial growth factors are differentially regulated by steroid hormones and antiestrogens in breast cancer cells, Molecular and Cellular Endocrinology, vol.149, issue.1-2, pp.29-40, 1999.
DOI : 10.1016/S0303-7207(99)00003-9

R. Soares, J. Reis-filho, F. Gartner, F. Schmitt, L. Iruela-arispa et al., Vascular Endothelial Growth Factor, Transforming Growth Factor-??, and Estrogen Receptors: Possible Cross-Talks and Interactions, The American Journal of Pathology, vol.160, issue.1, pp.381-384, 2002.
DOI : 10.1016/S0002-9440(10)64381-7
URL : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1867148/pdf

J. Nakamura, A. Savinov, Q. Lu, and A. Brodie, Estrogen regulates vascular endothelial growth/permeability factor expression in 7,12-dimethyl- benz(a)-anthracene-induced rat mammary tumors, Endocrinology, vol.137, pp.5589-96, 1996.

M. Mueller, J. Vigne, A. Minchenko, D. Lebovic, D. Leitman et al., Regulation of vascular endothelial growth factor (VEGF) gene transcription by estrogen receptors alpha and beta, Proceedings of the National Academy of Sciences, vol.13, issue.8, pp.10972-10979, 2000.
DOI : 10.1210/me.13.8.1225

S. Hyder, Z. Nawaz, D. Chiappetta, and G. Stancel, Identification of functional estrogen response elements in the gene coding for the potent angiogenic factor vascular endothelial growth factor, Cancer Res, vol.60, pp.3183-90, 2000.

U. Eppenberger, W. Kueng, J. Schlaeppi, J. Roesel, C. Benz et al., Markers of tumor angiogenesis and proteolysis independently define high- and low-risk subsets of node-negative breast cancer patients., Journal of Clinical Oncology, vol.16, issue.9, pp.3129-3165, 1998.
DOI : 10.1200/JCO.1998.16.9.3129

M. Toi, T. Matsumoto, and H. Bando, Vascular endothelial growth factor: its prognostic, predictive, and therapeutic implications, The Lancet Oncology, vol.2, issue.11, pp.667-73, 2001.
DOI : 10.1016/S1470-2045(01)00556-3

M. Toi, K. Inada, H. Suzuki, and T. Tominaga, Tumor angiogenesis in breast cancer: Its importance as a prognostic indicator and the association with vascular endothelial growth factor expression, Breast Cancer Research and Treatment, vol.194, issue.2, pp.193-204, 1995.
DOI : 10.1007/BF00666040

D. Paola, F. Granato, A. Scarpi, E. Monti, F. Medri et al., Vascular endothelial growth factor and prognosis in patients with node-negative breast cancer, International Journal of Cancer, vol.16, issue.2, pp.228-261, 2002.
DOI : 10.1002/ijc.10118

J. Lee, H. Kim, J. Jung, Y. Kim, M. Lee et al., Expression of Vascular Endothelial Growth Factor in Invasive Ductal Carcinoma of the Breast and the Relation to Angiogenesis and p53 and HER-2/neu Protein Expression, Applied Immunohistochemistry & Molecular Morphology, vol.10, issue.4, pp.289-95, 2002.
DOI : 10.1097/00129039-200212000-00001

J. Adams, P. Carder, S. Downey, M. Forbes, M. Lennan et al., Vascular endothelial factor (VEGF) in breast cancer: comparison of plasma, serum, and tissue VEGF and microvessel density and effects of tamoxifen, Cancer Res, vol.60, pp.2898-905, 2000.

G. Gasparini, M. Toi, M. Gion, P. Verderio, R. Dittadi et al., Prognostic Significance of Vascular Endothelial Growth Factor Protein in Node-Negative Breast Carcinoma, JNCI Journal of the National Cancer Institute, vol.89, issue.2, pp.139-186, 1997.
DOI : 10.1093/jnci/89.2.139

P. Manders, L. Beex, V. Tjan-heijnen, J. Geurts-moespot, T. Van-tienoven et al., The prognostic value of vascular endothelial growth factor in 574 node-negative breast cancer patients who did not receive adjuvant systemic therapy, British Journal of Cancer, vol.3, issue.7, pp.772-780, 2002.
DOI : 10.1038/sj.bjc.6600555

B. Linderholm, K. Grankvist, N. Wilking, M. Johansson, B. Tavelin et al., Correlation of Vascular Endothelial Growth Factor Content With Recurrences, Survival, and First Relapse Site in Primary Node-Positive Breast Carcinoma After Adjuvant Treatment, Journal of Clinical Oncology, vol.18, issue.7, pp.1423-1454, 2000.
DOI : 10.1200/JCO.2000.18.7.1423

G. Gasparini, T. M. Miceli, R. Vermeulen, P. Dittadi, R. Biganzoli et al., Clinical relevance of vascular endothelial growth factor and thymidine phosphorylase in patients with node-positive breast cancer treated with either adjuvant chemotherapy or hormone therapy, Cancer J Sci Am, vol.5, pp.101-112, 1999.

B. Linderholm, B. Lindh, B. Tavelin, K. Grankvist, and R. Henriksson, p53 and vascular-endothelial-growth-factor (VEGF) expression predicts outcome in 833 patients with primary breast carcinoma, International Journal of Cancer, vol.70, issue.1, pp.51-62, 2000.
DOI : 10.1002/(SICI)1097-0215(20000120)89:1<51::AID-IJC9>3.0.CO;2-8

S. Russell, D. Stern, P. Polverini, and J. Bender, Neuregulin activation of ErbB receptors in vascular endothelium leads to angiogenesis

F. Vinals and J. Pouyssegur, Transforming Growth Factor ??1 (TGF-??1) Promotes Endothelial Cell Survival during In Vitro Angiogenesis via an Autocrine Mechanism Implicating TGF-?? Signaling, Molecular and Cellular Biology, vol.21, issue.21, pp.7218-7248, 2001.
DOI : 10.1128/MCB.21.21.7218-7230.2001

H. Kim, H. Shin, H. Kwak, C. Cho, C. Lee et al., Betacellulin induces angiogenesis through activation of mitogen-activated protein kinase and phosphatidylinositol 3-kinase in endothelial cell, FASEB J, vol.17, pp.318-338, 2003.

S. Lejeune, R. Leek, E. Horak, G. Plowman, M. Greenall et al., Amphiregulin, epidermal growth factor receptor, and estrogen receptor expression in human primary breast cancer, Cancer Res, vol.53, pp.3597-602, 1993.

N. Normanno, N. Kim, D. Wen, K. Smith, A. Harris et al., Expression of messenger RNA for amphiregulin, heregulin, and cripto-1, three new members of the epidermal growth factor family, in human breast carcinomas, Breast Cancer Research and Treatment, vol.256, issue.3, pp.293-300, 1995.
DOI : 10.1007/BF00665981

L. Panico, D. Antonio, A. Salvatore, G. Mezza, E. Tortora et al., Differential immunohistochemical detection of transforming growth factor ??, amphiregulin and CRIPTO in human normal and malignant breast tissues, International Journal of Cancer, vol.420, issue.1, pp.51-57, 1996.
DOI : 10.1002/(SICI)1097-0215(19960103)65:1<51::AID-IJC9>3.0.CO;2-0

D. Visscher, F. Sarkar, T. Kasunic, and K. Redd, Clinicopathologic analysis of amphiregulin and heregulin immunostaining in breast neoplasia, Breast Cancer Research and Treatment, vol.10, issue.1, pp.75-80, 1997.
DOI : 10.1023/A:1005845512804

D. Salomon, N. Normanno, F. Ciardiello, R. Brandt, M. Shoyab et al., The role of amphiregulin in breast cancer, Breast Cancer Research and Treatment, vol.16, issue.2, pp.103-117, 1995.
DOI : 10.1007/BF00682718

L. Ma, C. Gauvillé, Y. Berthois, G. Johnson, and F. Calvo, Antisense expression for amphiregulin suppresses tumorigenicity of a transformed human breast epithelial cell line, Oncogene, vol.18, issue.47, pp.6513-6533, 1999.
DOI : 10.1038/sj.onc.1203042

M. Silvy, C. Giusti, P. Martin, and Y. Berthois, Differential regulation of cell proliferation and protease secretion by epidermal growth factor and amphiregulin in tumoral versus normal breast epithelial cells, British Journal of Cancer, vol.84, issue.7, pp.936-981, 2001.
DOI : 10.1054/bjoc.2000.1678

S. Romain, F. Spyratos, F. Descotes, A. Daver, B. Rostaing-puissant et al., Prognostic of DNA-synthesizing enzyme activities (thymidine kinase and thymidylate synthase) in 908 T1-T2, N0-N1, M0 breast cancers: A retrospective multicenter study, International Journal of Cancer, vol.75, issue.6, pp.860-868, 2000.
DOI : 10.1002/1097-0215(20000915)87:6<860::AID-IJC16>3.0.CO;2-Y

J. Foekens, H. Portengen, W. Van-putten, H. Peters, H. Krijnen et al., Prognostic value of estrogen and progesterone receptors measured by enzyme immunoassays in human breast cancer tumor cytosol, Cancer Res, vol.49, pp.5823-5831, 1989.

J. Foekens, R. S. Look, M. Martin, P. Klijn, and J. , Thymidine kinase and thymidylate synthase in advanced breast cancer: response to tamoxifen and chemotherapy, Cancer Res, vol.61, pp.1421-1426, 2001.

S. Romain, C. Lainé-bidron, P. Martin, and H. Magdelenat, steroid receptor distribution in 47 892 breast cancers. A collaborative study of 7 European laboratories, European Journal of Cancer, vol.31, issue.3, pp.411-428, 1995.
DOI : 10.1016/0959-8049(94)00496-R

K. Heer, H. Kumar, J. Read, J. Fox, J. Monson et al., Serum vascular endothelial growth factor in breast cancer: its relation with cancer type and estrogen receptor status, Clin Cancer Res, vol.7, pp.3491-3495, 2001.

J. Foekens, H. Peters, N. Grebenchtchikov, M. Look, M. Meijer-van-gelder et al., High tumor levels of vascular endothelial growth factor predict poor response to systemic therapy in advanced breast cancer, Cancer Res, vol.61, pp.5407-5421, 2001.

B. Linderholm, T. Lindahl, L. Holmberg, S. Klaar, J. Lennerstrand et al., The expression of vascular endothelial growth factor correlates with mutant p53 and poor prognosis in human breast cancer, Cancer Res, vol.61, pp.2256-60, 2001.

V. Ludovini, A. Sidoni, L. Pistola, G. Bellezza, D. Angelis et al., Evaluation of the Prognostic Role of Vascular Endothelial Growth Factor and Microvessel Density in Stages I and II Breast Cancer Patients, Breast Cancer Research and Treatment, vol.86, issue.3, pp.159-68, 2003.
DOI : 10.1023/A:1025755717912

M. Saceda, M. Lippman, R. Lindsey, M. Puente, and M. Martin, Role of an Estrogen Receptor-Dependent Mechanism in the Regulation of Estrogen Receptor mRNA in MCF-7 Cells, Molecular Endocrinology, vol.3, issue.11, pp.1782-1789, 1989.
DOI : 10.1210/mend-3-11-1782

Y. Berthois, X. Dong, M. Roux-dossetto, and P. Martin, Expression of estrogen receptor and its messenger ribonucleic acid in the MCF-7 cell line: multiparametric analysis of its processing and regulation by estrogen, Molecular and Cellular Endocrinology, vol.74, issue.1, pp.11-20, 1990.
DOI : 10.1016/0303-7207(90)90201-I

M. Gyling, G. Leclercq, and J. Heuson, Estrogenic and Antiestrogenic Down-regulation of Estrogen Receptor Levels: Evidence for two Different Mechanisms, Journal of Receptor Research, vol.57, issue.5-6, pp.217-251, 1990.
DOI : 10.3109/10799899009064667

E. Horak, R. Leek, N. Klenk, S. Lejeune, K. Smith et al., Angiogenesis, assessed by platelet/endothelial cell adhesion molecule antibodies, as indicator of node metastases and survival in breast cancer, The Lancet, vol.340, issue.8828, pp.1120-1124, 1992.
DOI : 10.1016/0140-6736(92)93150-L

G. Gasparini, Clinical significance of determination of surrogate markers of angiogenesis in breast cancer, Critical Reviews in Oncology/Hematology, vol.37, issue.2, pp.97-114, 2001.
DOI : 10.1016/S1040-8428(00)00105-0

A. Obermair, E. Kucera, K. Mayerhoffer, P. Speiser, M. Seifert et al., Vascular endothelial growth factor (VEGF) in human breast cancer: Correlation with disease-free survival, International Journal of Cancer, vol.56, issue.4, pp.455-463, 1997.
DOI : 10.1002/(SICI)1097-0215(19970822)74:4<455::AID-IJC17>3.0.CO;2-8

B. Linderholm, B. Tavelin, K. Grankvist, and R. Henriksson, Vascular endothelial growth factor is of high prognostic value in node-negative breast carcinoma., Journal of Clinical Oncology, vol.16, issue.9, pp.3121-3129, 1998.
DOI : 10.1200/JCO.1998.16.9.3121

E. Berns, J. Klijn, M. Look, N. Grebenchtchikov, R. Vossen et al., Combined vascular endothelial growth factor and TP53 status predicts poor response to tamoxifen therapy in estrogen receptor-positive advanced breast cancer, Clin Cancer Res, vol.9, pp.1253-1261, 2003.

L. Ma, A. De-roquancourt, P. Bertheau, S. Chevret, G. Millot et al., Expression of amphiregulin and epidermal growth factor receptor in human breast cancer: analysis of autocriny and stromal-epithelial interactions, The Journal of Pathology, vol.33, issue.4, pp.413-422, 2001.
DOI : 10.1002/path.902

C. Qi, D. Liscia, N. Normanno, G. Merlo, G. Johnson et al., Expression of transforming growth factor ??, amphiregulin and cripto-1 in human breast carcinomas, British Journal of Cancer, vol.69, issue.5, pp.903-913, 1994.
DOI : 10.1038/bjc.1994.174

I. Martinez-lacaci, M. Saceda, G. Plowman, G. Johnson, N. Normanno et al., Estrogen and phorbol esters regulate amphiregulin expression by two separate mechanisms in human breast cancer cell lines, Endocrinology, vol.136, pp.3983-92, 1995.

M. Look, W. Van-putten, M. Duffy, N. Harbeck, I. Christensen et al., Pooled Analysis of Prognostic Impact of Urokinase-Type Plasminogen Activator and Its Inhibitor PAI-1 in 8377 Breast Cancer Patients, JNCI Journal of the National Cancer Institute, vol.94, issue.2, pp.116-144, 2002.
DOI : 10.1093/jnci/94.2.116

C. Giusti, S. Desruisseau, L. Ma, F. Calvo, P. Martin et al., Transforming growth factor ?-1 and amphiregulin act in synergy to increase the production of urokinase-type plasminogen activator in transformed breast epithelial cells, International Journal of Cancer, vol.13, issue.6, pp.769-78, 2003.
DOI : 10.1002/ijc.11158
URL : https://hal.archives-ouvertes.fr/inserm-00156319

G. Fontanini, D. Laurentiis, M. Vignati, S. Chinè, S. Lucchi et al., Evaluation of epidermal growth factor-related growth factors and receptors and of neoangiogenesis in completely resected stage I-IIIA non-small-cell lung cancer: amphiregulin and microvessel count are independent prognostic indicators of survival, Clinical Cancer Res, vol.4, pp.241-250, 1998.

I. Martinez-lacaci, G. Johnson, D. Salomon, and R. Dickson, Characterization of a novel amphiregulin-related molecule in 12-O-tetradecanoylphorbol-13-acetate-treated breast cancer cells, Journal of Cellular Physiology, vol.64, issue.3, pp.497-508, 1996.
DOI : 10.1002/(SICI)1097-4652(199612)169:3<497::AID-JCP10>3.0.CO;2-3

G. Johnson, T. Saeki, N. Auersperg, A. Gordon, M. Shoyab et al., Response to and expression of amphiregulin by ovarian carcinoma and normal ovarian surface epithelial cells: Nuclear localization of endogenous amphiregulin, Biochemical and Biophysical Research Communications, vol.180, issue.2, pp.481-489, 1991.
DOI : 10.1016/S0006-291X(05)81090-3