R. Lee, R. Feinbaum, and A. V. , The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14, Cell, vol.75, issue.5, pp.843-54, 1993.
DOI : 10.1016/0092-8674(93)90529-Y
URL : https://hal.archives-ouvertes.fr/in2p3-00597159

B. Lewis, C. Burge, and D. Bartel, Conserved Seed Pairing, Often Flanked by Adenosines, Indicates that Thousands of Human Genes are MicroRNA Targets, Cell, vol.120, issue.1, pp.15-20, 2005.
DOI : 10.1016/j.cell.2004.12.035

X. Xie, J. Lu, and E. Kulbokas, Systematic discovery of regulatory motifs in human promoters and 3??? UTRs by comparison of several mammals, Nature, vol.55, issue.7031, pp.338-383, 2005.
DOI : 10.1016/S0968-0004(00)89102-1

I. Bentwich, A. Avniel, and Y. Karov, Identification of hundreds of conserved and nonconserved human microRNAs, Nature Genetics, vol.37, issue.7, pp.766-70, 2005.
DOI : 10.1101/gad.862301

G. Calin and C. Croce, MicroRNA signatures in human cancers, Nature Reviews Cancer, vol.59, issue.11, pp.857-66, 2006.
DOI : 10.1677/erc.1.01209

G. Borchert, W. Lanier, and B. Davidson, RNA polymerase III transcribes human microRNAs, Nature Structural & Molecular Biology, vol.13, issue.12, pp.1097-101, 2006.
DOI : 10.1038/nsmb1167

G. Hutvagner, J. Mclachlan, and A. Pasquinelli, A Cellular Function for the RNA-Interference Enzyme Dicer in the Maturation of the let-7 Small Temporal RNA, Science, vol.293, issue.5531, pp.834-842, 2001.
DOI : 10.1126/science.1062961

Y. Lee, C. Ahn, and J. Han, The nuclear RNase III Drosha initiates microRNA processing, Nature, vol.425, issue.6956, pp.415-424, 2003.
DOI : 10.1038/nature01957

Y. Lee, K. Nakahara, and J. Pham, Distinct Roles for Drosophila Dicer-1 and Dicer-2 in the siRNA/miRNA Silencing Pathways, Cell, vol.117, issue.1, pp.69-81, 2004.
DOI : 10.1016/S0092-8674(04)00261-2

J. Cavaillé, Des microARN comme s???il en pleuvait???, m??decine/sciences, vol.20, issue.4, pp.399-401, 2004.
DOI : 10.1051/medsci/2004204399

J. Han, Y. Lee, and K. Yeom, The Drosha-DGCR8 complex in primary microRNA processing, Genes & Development, vol.18, issue.24, pp.3016-3043, 2004.
DOI : 10.1101/gad.1262504

K. Yeom, Y. Lee, J. Han, M. Suh, and V. Kim, Characterization of DGCR8/Pasha, the essential cofactor for Drosha in primary miRNA processing, Nucleic Acids Research, vol.34, issue.16, pp.4622-4631, 2006.
DOI : 10.1093/nar/gkl458

A. Khvorova, R. A. Jayasena, and S. , Functional siRNAs and miRNAs Exhibit Strand Bias, Cell, vol.115, issue.2, pp.209-225, 2003.
DOI : 10.1016/S0092-8674(03)00801-8
URL : http://doi.org/10.1016/s0092-8674(03)00893-6

D. Schwarz, G. Hutvagner, and T. Du, Asymmetry in the Assembly of the RNAi Enzyme Complex, Cell, vol.115, issue.2, pp.199-208, 2003.
DOI : 10.1016/S0092-8674(03)00759-1

L. Lim, N. Lau, and P. Garrett-engele, Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs, Nature, vol.22, issue.7027, pp.769-73, 2005.
DOI : 10.1016/S0092-8674(00)00015-5

S. Bagga, J. Bracht, and S. Hunter, Regulation by let-7 and lin-4 miRNAs Results in Target mRNA Degradation, Cell, vol.122, issue.4, pp.553-63, 2005.
DOI : 10.1016/j.cell.2005.07.031

A. Giraldez, Y. Mishima, and J. Rihel, Zebrafish MiR-430 Promotes Deadenylation and Clearance of Maternal mRNAs, Science, vol.312, issue.5770, pp.75-84, 2006.
DOI : 10.1126/science.1122689

L. Wu, J. Fan, and J. Belasco, MicroRNAs direct rapid deadenylation of mRNA, Proceedings of the National Academy of Sciences, vol.115, issue.7, pp.4034-4043, 2006.
DOI : 10.1016/S0092-8674(03)01018-3

J. Liu, M. Valencia-sanchez, G. Hannon, and R. Parker, MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies, Nature Cell Biology, vol.7, issue.7, pp.719-742, 2005.
DOI : 10.1261/rna.2340405

B. Engels and G. Hutvagner, Principles and effects of microRNA-mediated post-transcriptional gene regulation, Oncogene, vol.25, issue.46, pp.6163-6172, 2006.
DOI : 10.1038/nature04688

C. Chu and T. Rana, Translation Repression in Human Cells by MicroRNA-Induced Gene Silencing Requires RCK/p54, PLoS Biology, vol.142, issue.7, p.210, 2006.
DOI : 10.1371/journal.pbio.0040210.sg003

S. Newbury, O. Muhlemann, and G. Stoecklin, Turnover in the Alps: an mRNA perspective, EMBO reports, vol.3, issue.2, pp.143-151, 2006.
DOI : 10.1016/j.cell.2005.04.030

K. Pauley, T. Eystathioy, and A. Jakymiw, Formation of GW bodies is a consequence of microRNA genesis, EMBO reports, vol.7, issue.9, pp.904-914, 2006.
DOI : 10.1261/rna.2142405

J. Rehwinkel, I. Behm-ansmant, D. Gatfield, and E. Izaurralde, A crucial role for GW182 and the DCP1:DCP2 decapping complex in miRNA-mediated gene silencing, RNA, vol.11, issue.11, pp.1640-1647, 2005.
DOI : 10.1261/rna.2191905

I. Bruno and M. Wilkinson, P-Bodies React to Stress and Nonsense, Cell, vol.125, issue.6, pp.1036-1044, 2006.
DOI : 10.1016/j.cell.2006.06.003

J. Brennecke, D. Hipfner, and A. Stark, bantam Encodes a Developmentally Regulated microRNA that Controls Cell Proliferation and Regulates the Proapoptotic Gene hid in Drosophila, Cell, vol.113, issue.1, pp.25-36, 2003.
DOI : 10.1016/S0092-8674(03)00231-9

D. Leaman, P. Chen, and J. Fak, Antisense-Mediated Depletion Reveals Essential and Specific Functions of MicroRNAs in Drosophila Development, Cell, vol.121, issue.7, pp.1097-108, 2005.
DOI : 10.1016/j.cell.2005.04.016

S. Chang, R. Johnston, . Jr, and C. Frokjaer-jensen, MicroRNAs act sequentially and asymmetrically to control chemosensory laterality in the nematode, Nature, vol.32, issue.7001, pp.785-794, 2004.
DOI : 10.1006/dbio.2002.0850

C. Chen, L. Li, H. Lodish, and D. Bartel, MicroRNAs Modulate Hematopoietic Lineage Differentiation, Science, vol.303, issue.5654, pp.83-89, 2004.
DOI : 10.1126/science.1091903

M. Poy, L. Eliasson, and J. Krutzfeldt, A pancreatic islet-specific microRNA regulates insulin secretion, Nature, vol.31, issue.7014, pp.226-256, 2004.
DOI : 10.1038/nature03076

C. Esau, X. Kang, and E. Peralta, MicroRNA-143 Regulates Adipocyte Differentiation, Journal of Biological Chemistry, vol.279, issue.50, pp.52361-52366, 2004.
DOI : 10.1074/jbc.C400438200

Y. Zhao, E. Samal, and D. Srivastava, Serum response factor regulates a muscle-specific microRNA that targets Hand2 during cardiogenesis, Nature, vol.7, issue.7048, pp.214-234, 2005.
DOI : 10.1093/nar/gkg595

A. Stark, J. Brennecke, and N. Bushati, Animal MicroRNAs Confer Robustness to Gene Expression and Have a Significant Impact on 3???UTR Evolution, Cell, vol.123, issue.6, pp.1133-1179, 2005.
DOI : 10.1016/j.cell.2005.11.023

G. Calin, C. Sevignani, and C. Dumitru, Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers, Proceedings of the National Academy of Sciences, vol.39, issue.2, pp.2999-3004, 2004.
DOI : 10.1002/gcc.10316

J. Thomson, M. Newman, and J. Parker, Extensive post-transcriptional regulation of microRNAs and its implications for cancer, Genes & Development, vol.20, issue.16, pp.2202-2209, 2006.
DOI : 10.1101/gad.1444406

M. Metzler, W. M. Busch, and K. , High expression of precursor microRNA-155/BIC RNA in children with Burkitt lymphoma, Genes, Chromosomes and Cancer, vol.13, issue.2, pp.167-176, 2004.
DOI : 10.1002/gcc.10316

M. Iorio, M. Ferracin, and C. Liu, MicroRNA Gene Expression Deregulation in Human Breast Cancer, Cancer Research, vol.65, issue.16, pp.7065-70, 2005.
DOI : 10.1158/0008-5472.CAN-05-1783

J. Takamizawa, H. Konishi, and K. Yanagisawa, Reduced Expression of the let-7 MicroRNAs in Human Lung Cancers in Association with Shortened Postoperative Survival, Cancer Research, vol.64, issue.11, pp.3753-3759, 2004.
DOI : 10.1158/0008-5472.CAN-04-0637

J. Chan, A. Krichevsky, and K. Kosik, MicroRNA-21 Is an Antiapoptotic Factor in Human Glioblastoma Cells, Cancer Research, vol.65, issue.14, pp.6029-6062, 2005.
DOI : 10.1158/0008-5472.CAN-05-0137

M. Michael, S. Oc, N. Van-holst-pellekaan, G. Young, and R. James, Reduced accumulation of specific microRNAs in colorectal neoplasia, Mol Cancer Res, vol.1, pp.882-91, 2003.

L. He, J. Thomson, and M. Hemann, A microRNA polycistron as a potential human oncogene, Nature, vol.1, issue.7043, pp.828-861, 2005.
DOI : 10.1093/BIOINFORMATICS/16.11.1046

G. Calin, M. Ferracin, and A. Cimmino, A MicroRNA Signature Associated with Prognosis and Progression in Chronic Lymphocytic Leukemia, New England Journal of Medicine, vol.353, issue.17, pp.1793-801, 2005.
DOI : 10.1056/NEJMoa050995

O. Donnell, K. Wentzel, E. Zeller, and K. , c-Myc-regulated microRNAs modulate E2F1 expression, Nature, vol.2, issue.7043, pp.839-882, 2005.
DOI : 10.1016/j.jmb.2004.03.065

J. Lu, G. Getz, and E. Miska, MicroRNA expression profiles classify human cancers, Nature, vol.1, issue.7043, pp.834-842, 2005.
DOI : 10.1016/S1535-6108(02)00018-1

S. Volinia, G. Calin, and C. Liu, A microRNA expression signature of human solid tumors defines cancer gene targets, Proceedings of the National Academy of Sciences, vol.99, issue.10, pp.2257-61, 2006.
DOI : 10.1073/pnas.082099299

Y. Akao, Y. Nakagawa, and T. Naoe, let-7 MicroRNA Functions as a Potential Growth Suppressor in Human Colon Cancer Cells, Biological & Pharmaceutical Bulletin, vol.29, issue.5, pp.903-909, 2006.
DOI : 10.1248/bpb.29.903

E. Bandres, E. Cubedo, and X. Agirre, Identification by Real-time PCR of 13 mature microRNAs differentially expressed in colorectal cancer and non-tumoral tissues, Molecular Cancer, vol.5, issue.1, p.29, 2006.
DOI : 10.1186/1476-4598-5-29

Y. Xi, R. Shalgi, O. Fodstad, Y. Pilpel, and J. Ju, Differentially Regulated Micro-RNAs and Actively Translated Messenger RNA Transcripts by Tumor Suppressor p53 in Colon Cancer, Clinical Cancer Research, vol.12, issue.7, pp.2014-2038, 2006.
DOI : 10.1158/1078-0432.CCR-05-1853

J. Cummins, Y. He, and R. Leary, The colorectal microRNAome, Proceedings of the National Academy of Sciences, vol.11, issue.11, pp.3687-92, 2006.
DOI : 10.1261/rna.2148705

Q. Jing, S. Huang, and S. Guth, Involvement of MicroRNA in AU-Rich Element-Mediated mRNA Instability, Cell, vol.120, issue.5, pp.623-657, 2005.
DOI : 10.1016/j.cell.2004.12.038

L. Navarro, P. Dunoyer, and F. Jay, A Plant miRNA Contributes to Antibacterial Resistance by Repressing Auxin Signaling, Science, vol.123, issue.6, pp.436-445, 2006.
DOI : 10.1016/j.cell.2005.11.023
URL : https://hal.archives-ouvertes.fr/hal-00093086

K. Taganov, M. Boldin, K. Chang, and D. Baltimore, NF-??B-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses, Proceedings of the National Academy of Sciences, vol.21, issue.19, pp.12481-12487, 2006.
DOI : 10.1093/emboj/cdf505

B. Lewis, I. Shih, M. Jones-rhoades, D. Bartel, and C. Burge, Prediction of Mammalian MicroRNA Targets, Cell, vol.115, issue.7, pp.787-98, 2003.
DOI : 10.1016/S0092-8674(03)01018-3

S. Grewal and D. Moazed, Heterochromatin and Epigenetic Control of Gene Expression, Science, vol.301, issue.5634, pp.798-802, 2003.
DOI : 10.1126/science.1086887

A. Cimmino, G. Calin, and M. Fabbri, miR-15 and miR-16 induce apoptosis by targeting BCL2, Proceedings of the National Academy of Sciences, vol.101, issue.11, pp.13944-13953, 2005.
DOI : 10.1002/cncr.20696

G. Calin, C. Dumitru, and M. Shimizu, Nonlinear partial differential equations and applications: Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia, Proceedings of the National Academy of Sciences, vol.133, issue.2, pp.15524-15533, 2002.
DOI : 10.1016/S0165-4608(01)00583-0

M. Iorio, M. Ferracin, and C. Liu, MicroRNA Gene Expression Deregulation in Human Breast Cancer, Cancer Research, vol.65, issue.16, pp.7065-70, 2005.
DOI : 10.1158/0008-5472.CAN-05-1783

M. Michael, O. Connor, S. Van-holst-pellekaan, and N. , Reduced accumulation of specific microRNAs in colorectal neoplasia, Mol Cancer Res, vol.1, pp.882-91, 2003.

J. Chan, A. Krichevsky, and K. Kosik, MicroRNA-21 Is an Antiapoptotic Factor in Human Glioblastoma Cells, Cancer Research, vol.65, issue.14, pp.6029-6062, 2005.
DOI : 10.1158/0008-5472.CAN-05-0137

S. Johnson, H. Grosshans, and J. Shingara, RAS Is Regulated by the let-7 MicroRNA Family, Cell, vol.120, issue.5, pp.635-682, 2005.
DOI : 10.1016/j.cell.2005.01.014

M. Lagos-quintana, R. Rauhut, and A. Yalcin, Identification of Tissue-Specific MicroRNAs from Mouse, Current Biology, vol.12, issue.9, pp.735-744, 2002.
DOI : 10.1016/S0960-9822(02)00809-6

P. Eis, W. Tam, and L. Sun, Accumulation of miR-155 and BIC RNA in human B cell lymphomas, Proceedings of the National Academy of Sciences, vol.117, issue.5, pp.3627-3659, 2005.
DOI : 10.1016/S0092-8674(04)00419-2

L. He, J. Thomson, and M. Hemann, A microRNA polycistron as a potential human oncogene, Nature, vol.1, issue.7043, pp.828-861, 2005.
DOI : 10.1093/BIOINFORMATICS/16.11.1046

O. Donnell, K. Wentzel, E. Zeller, and K. , c-Myc-regulated microRNAs modulate E2F1 expression, Nature, vol.2, issue.7043, pp.839-882, 2005.
DOI : 10.1016/j.jmb.2004.03.065

Y. Hayashita, H. Osada, and Y. Tatematsu, A Polycistronic MicroRNA Cluster, miR-17-92, Is Overexpressed in Human Lung Cancers and Enhances Cell Proliferation, Cancer Research, vol.65, issue.21, pp.9628-9660, 2005.
DOI : 10.1158/0008-5472.CAN-05-2352