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Physiomer reduces the chemokine interleukin-8 production by activated human respiratory epithelial cells.

Abstract : The authors have recently shown that the transcription factor nuclear factor-kappaB (NF-kappaB) is a central mediator in the NaCl-mediated interleukin (IL)-8 production by human airway epithelial cells. In this study, it was investigated whether Physiomer, an isotonic sea water-derived solution commercialized for cleaning the nasal mucosa, impaired the chemokine IL-8 expression and secretion by human respiratory epithelial cells compared with that obtained with an isotonic 9% NaCl solution. Primary human bronchial gland (HBG) epithelial cells were incubated either in Physiomer or in a NaCl 9% solution and activated either with 20 ng x mL(-1) tumour necrosis factor-alpha, or IL-1beta, respectively. Physiomer significantly reduced the IL-8 protein release in basal and activated HBG cells in comparison with that obtained with the 9% NaCl solution. In contrast to the effects of Physiomer observed on resting HBG cells, Physiomer did not significantly reduce the level of phosphorylation of the NF-kappaB inhibitor protein IkappaBalpha or the steady-state IL-8 messenger ribonucleic acid levels in activated HBG cells, suggesting that Physiomer would have a post-transcriptional effect on IL-8 expression in activated HBG cells. The authors conclude that Physiomer is potentially useful in the reduction of airway mucosal inflammation.
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Contributor : Philippe Birembaut Connect in order to contact the contributor
Submitted on : Thursday, June 7, 2007 - 10:14:09 AM
Last modification on : Tuesday, December 14, 2021 - 12:22:02 PM


  • HAL Id : inserm-00152549, version 1
  • PUBMED : 11716171



O. Tabary, C. Muselet, J. C. Yvin, B. Halley-Vanhove, E. Puchelle, et al.. Physiomer reduces the chemokine interleukin-8 production by activated human respiratory epithelial cells.. European Respiratory Journal, European Respiratory Society, 2001, 18 (4), pp.661-6. ⟨inserm-00152549⟩



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