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Cyclin D1 gene G870A polymorphism predicts response to neoadjuvant radiotherapy and prognosis in rectal cancer.

Abstract : PURPOSE: To investigate whether CCND1 genetic variations associated with a constitutive nuclear protein may influence either the pathologic response to preoperative RT or the prognosis in a series of rectal cancer patients. METHODS AND MATERIALS: Seventy rectal cancer patients treated by neoadjuvant radiotherapy were included in the study. CCND1 exon 5 mutations were screened, and the G870A polymorphism was assessed for correlation with clinical variables, tumor response, and patient outcome. RESULTS: No exon 5 mutation was found. Concerning the G870A polymorphism, the A/A variant was significantly associated with radiosensitivity (p = 0.022). Moreover, patients harboring the A allele were correlated with a lower risk of local failure (p = 0.017). Also, combination of the G870A polymorphism with the post-therapeutic lymph node status allowed the elaboration of a prognostic index, which accurately distinguished subgroups of patients with predictable recurrence-free (p = 0.003) and overall (p = 0.044) survival. CONCLUSIONS: Although CCND1 exon 5 mutations are rare in rectal cancer, G870A polymorphism is a frequent variation that may predict radiosensitivity and prognosis.
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https://www.hal.inserm.fr/inserm-00150983
Contributor : Yves Le Ster Connect in order to contact the contributor
Submitted on : Monday, June 4, 2007 - 12:47:48 PM
Last modification on : Sunday, September 4, 2022 - 5:52:23 PM
Long-term archiving on: : Thursday, April 8, 2010 - 5:15:50 PM

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Alexandre Ho-Pun-Cheung, Eric Assénat, Simon Thezenas, Frédéric Bibeau, Rouanet Philippe, et al.. Cyclin D1 gene G870A polymorphism predicts response to neoadjuvant radiotherapy and prognosis in rectal cancer.. International Journal of Radiation Oncology, Biology, Physics, Elsevier, 2007, 68 (4), pp.1094-101. ⟨10.1016/j.ijrobp.2007.01.022⟩. ⟨inserm-00150983⟩

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