J. J. Letterio and A. B. Roberts, TGF-??: A Critical Modulator of Immune Cell Function, Clinical Immunology and Immunopathology, vol.84, issue.3, pp.244-250, 1997.
DOI : 10.1006/clin.1997.4409

J. Massagué, TGF-?? SIGNAL TRANSDUCTION, Annual Review of Biochemistry, vol.67, issue.1, pp.753-791, 1998.
DOI : 10.1146/annurev.biochem.67.1.753

R. Derynck, Y. Zhang, and X. H. Feng, Transcriptional Activators of TGF-?? Responses: Smads, Cell, vol.95, issue.6, pp.737-740, 1998.
DOI : 10.1016/S0092-8674(00)81696-7

J. Massagué and D. Wotton, NEW EMBO MEMBERS REVIEW: Transcriptional control by the TGF-beta/Smad signaling system, The EMBO Journal, vol.19, issue.8, pp.1745-1754, 2000.
DOI : 10.1093/emboj/19.8.1745

M. B. Goldring, The Role of Cytokines as Inflammatory Mediators in Osteoarthritis: Lessons from Animal Models, Connective Tissue Research, vol.158, issue.1, pp.1-11, 1999.
DOI : 10.1016/S1063-4584(97)80007-6

C. Deluca, H. Kwon, R. Lin, M. Wainberg, and J. Hiscott, NF-??B activation and HIV-1 induced apoptosis, Cytokine & Growth Factor Reviews, vol.10, issue.3-4, pp.235-53, 1999.
DOI : 10.1016/S1359-6101(99)00015-5

P. Bauerle and T. Henkel, Function and Activation of NF-kappaB in the Immune System, Annual Review of Immunology, vol.12, issue.1, pp.141-179, 1994.
DOI : 10.1146/annurev.iy.12.040194.001041

S. Ghosh, M. J. May, and E. B. Kopp, NF-??B AND REL PROTEINS: Evolutionarily Conserved Mediators of Immune Responses, Annual Review of Immunology, vol.16, issue.1, pp.225-260, 1998.
DOI : 10.1146/annurev.immunol.16.1.225

M. Karin, Z. Liu, and E. Zandi, AP-1 function and regulation, Current Opinion in Cell Biology, vol.9, issue.2, pp.240-246, 1997.
DOI : 10.1016/S0955-0674(97)80068-3

R. Wisdom, AP-1: One Switch for Many Signals, Experimental Cell Research, vol.253, issue.1, pp.180-185, 1999.
DOI : 10.1006/excr.1999.4685

L. D. Kerr, D. B. Miller, and L. M. Matrisian, TGF-??1 inhibition of transin/stromelysin gene expression is mediated through a fos binding sequence, Cell, vol.61, issue.2, pp.267-278, 1990.
DOI : 10.1016/0092-8674(90)90807-Q

K. Y. Chung, A. Agarwal, J. Uitto, and A. Mauviel, An AP-1 Binding Sequence Is Essential for Regulation of the Human 2(I) Collagen (COL1A2) Promoter Activity by Transforming Growth Factor-, Journal of Biological Chemistry, vol.271, issue.6, pp.3272-3278, 1996.
DOI : 10.1074/jbc.271.6.3272

A. Alevizopoulos and N. Mermod, Antagonistic Regulation of a Proline-rich Transcription Factor by Transforming Growth Factor ?? and Tumor Necrosis Factor ??, Journal of Biological Chemistry, vol.271, issue.47, pp.29672-29678, 1996.
DOI : 10.1074/jbc.271.47.29672

R. P. Nagarajan, F. Chen, W. Li, E. Vig, M. A. Harrington et al., Repression of transforming-growth-factor-??-mediated transcription by nuclear factor ??B, Biochemical Journal, vol.348, issue.3, pp.591-596, 2000.
DOI : 10.1042/bj3480591

L. Zawel, L. Dai, J. Buckhaults, P. Zhou, S. Kinzler et al., Human Smad3 and Smad4 Are Sequence-Specific Transcription Activators, Molecular Cell, vol.1, issue.4, pp.611-617, 1998.
DOI : 10.1016/S1097-2765(00)80061-1

R. Chiu, P. Angel, K. , and M. , Jun-B differs in its biological properties from, and is a negative regulator of, c-Jun, Cell, vol.59, issue.6, pp.979-986, 1989.
DOI : 10.1016/0092-8674(89)90754-X

A. Atfi, M. Buisine, A. Mazars, and C. Gespach, Induction of Apoptosis by DPC4, a Transcriptional Factor Regulated by Transforming Growth Factor-?? through Stress-activated Protein Kinase/c-Jun N-terminal Kinase (SAPK/JNK) Signaling Pathway, Journal of Biological Chemistry, vol.272, issue.40, pp.24731-24734, 1997.
DOI : 10.1074/jbc.272.40.24731

S. Dennler, S. Itoh, D. Vivien, P. Ten-dijke, S. Huet et al., Direct binding of Smad3 and Smad4 to critical TGFbeta -inducible elements in the promoter of human plasminogen activator inhibitor-type 1gene, The EMBO Journal, vol.17, issue.11, pp.3091-3100, 1998.
DOI : 10.1093/emboj/17.11.3091

N. C. Andrews and D. V. Faller, A rapid micrqpreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells, Nucleic Acids Research, vol.19, issue.9, p.2499, 1991.
DOI : 10.1093/nar/19.9.2499

L. Vindevoghel, A. Kon, R. J. Lechleider, J. Uitto, A. B. Roberts et al., Smad-dependent Transcriptional Activation of Human Type VII Collagen Gene (COL7A1) Promoter by Transforming Growth Factor-??, Journal of Biological Chemistry, vol.273, issue.21, pp.13053-13057, 1998.
DOI : 10.1074/jbc.273.21.13053

S. J. Chen, W. Yuan, Y. Mori, A. Levenson, M. Trojanowska et al., Stimulation of Type I Collagen Transcription in Human Skin Fibroblasts by TGF-??: Involvement of Smad 3, Journal of Investigative Dermatology, vol.112, issue.1, pp.49-57, 1999.
DOI : 10.1046/j.1523-1747.1999.00477.x

G. Von-gersdorff, K. Susztak, F. Rezvani, M. Bitzer, D. Liang et al., Smad3 and Smad4 Mediate Transcriptional Activation of the Human Smad7 Promoter by Transforming Growth Factor beta, Journal of Biological Chemistry, vol.275, issue.15, pp.11320-11326, 2000.
DOI : 10.1074/jbc.275.15.11320

A. Mauviel, Y. Q. Chen, W. Dong, C. H. Evans, and J. Uitto, Transcriptional interactions of transforming growth-factor-?? with pro-inflammatory cytokines, Current Biology, vol.3, issue.12, pp.822-831, 1993.
DOI : 10.1016/0960-9822(93)90216-B

URL : https://hal.archives-ouvertes.fr/inserm-00147456

N. T. Liberati, M. B. Datto, J. P. Frederick, X. Shen, C. Wong et al., Smads bind directly to the Jun family of AP-1 transcription factors, Proceedings of the National Academy of Sciences, vol.12, issue.14, pp.4844-4849, 1999.
DOI : 10.1101/gad.12.14.2153

M. O. Hottiger, L. K. Felzien, and G. J. Nabel, Modulation of cytokine-induced HIV gene expression by competitive binding of transcription factors to the coactivator p300, The EMBO Journal, vol.17, issue.11, pp.3124-3134, 1998.
DOI : 10.1093/emboj/17.11.3124

X. H. Feng, Y. Zhang, R. Y. Wu, and R. Derynck, The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for Smad3 in TGF-beta -induced transcriptional??activation, Genes & Development, vol.12, issue.14, pp.2153-2163, 1998.
DOI : 10.1101/gad.12.14.2153

R. Janknecht, N. J. Wells, and T. Hunter, TGF-beta -stimulated cooperation of Smad proteins with the coactivators??CBP/p300, Genes & Development, vol.12, issue.14, pp.2114-2119, 1998.
DOI : 10.1101/gad.12.14.2114

X. Shen, P. P. Hu, N. T. Liberati, M. B. Datto, J. P. Frederick et al., TGF-beta -induced Phosphorylation of Smad3 Regulates Its Interaction with Coactivator p300/CREB-binding Protein, Molecular Biology of the Cell, vol.9, issue.12, pp.3309-3319, 1998.
DOI : 10.1091/mbc.9.12.3309

Y. Shi, Y. F. Wang, L. Jayaraman, H. Yang, J. Massagué et al., Crystal Structure of a Smad MH1 Domain Bound to DNA, Cell, vol.94, issue.5, pp.585-594, 1998.
DOI : 10.1016/S0092-8674(00)81600-1

Y. Kamei, L. Xu, T. Heinzel, J. Torchia, R. Kurokawa et al., A CBP Integrator Complex Mediates Transcriptional Activation and AP-1 Inhibition by Nuclear Receptors, Cell, vol.85, issue.3, pp.403-414, 1996.
DOI : 10.1016/S0092-8674(00)81118-6

J. S. Lee, R. H. See, T. Deng, and Y. Shi, Adenovirus E1A downregulates cJun- and JunB-mediated transcription by targeting their coactivator p300., Molecular and Cellular Biology, vol.16, issue.8, pp.4312-4326, 1996.
DOI : 10.1128/MCB.16.8.4312

S. B. Maggirwar, S. Ramirez, N. Tong, H. A. Gelbard, and S. Dewhurst, Functional Interplay Between Nuclear Factor-??B and c-Jun Integrated by Coactivator p300 Determines the Survival of Nerve Growth Factor-Dependent PC12 Cells, Journal of Neurochemistry, vol.1, issue.2, pp.527-539, 2000.
DOI : 10.1046/j.1471-4159.2000.740527.x

A. Kon, L. Vindevoghel, D. J. Kouba, Y. Fujimura, J. Uitto et al., Cooperation between SMAD and NF-??B in growth factor regulated type VII collagen gene expression, Oncogene, vol.18, issue.10, pp.1837-1844, 1999.
DOI : 10.1038/sj.onc.1202495