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Increased BRCA1 protein in mammary tumours of rats fed marine omega-3 fatty acids.

Abstract : Any factor affecting BRCA gene regulation may be of interest in the prevention of breast tumourigenesis. We studied the influence of dietary docosahexaenoic acid (DHA), a major omega-3 fatty acid present in marine products, on rat autochthonous mammary tumourigenesis. DHA-supplementation significantly reduced the incidence of tumours (30%, P=0.007) and led to a 60% increase (P=0.02) in BRCA1 protein level. Since DHA influences the product of a major tumour suppressor gene, this finding may contribute to the observation that high-fish consumption reduces the risk of breast cancer.
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https://www.hal.inserm.fr/inserm-00149725
Contributor : Pascale Rio <>
Submitted on : Monday, May 28, 2007 - 11:30:44 AM
Last modification on : Thursday, June 11, 2020 - 3:19:22 AM

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  • HAL Id : inserm-00149725, version 1
  • PUBMED : 17342305

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Marie-Lise Jourdan, Karine Mahéo, Aurélia Barascu, Caroline Goupille, Monique Peffault de Latour, et al.. Increased BRCA1 protein in mammary tumours of rats fed marine omega-3 fatty acids.. Oncology Reports, Spandidos Publications, 2007, 17 (4), pp.713-9. ⟨inserm-00149725⟩

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