Skip to Main content Skip to Navigation
Journal articles

Quantitative videomicoscopic analysis of the sociologic behavior of non-invasive and invasive tumor cell lines: Sociologic behavior of cell lines

Abstract : To analyze the spatial distribution of tumor cell lines with different invasive properties, we used time-lapse videomicroscopic recordings associated with software programs we have developed for quantification. We observed that non-invasive tumor cells rapidly formed small clusters which aggregated to form larger clusters, whereas highly invasive tumor cells remained isolated and did not form clusters. An attraction index computed from a cellular automaton model was used to quantify the degree of attraction-repulsion between cells. The results suggest that the cluster formation by non-invasive cells is not related to a global attraction model and that the random (dispersed) distribution of invasive cells is not related to cell repulsion. According to these results, we can conclude that random cell movement combined with the intrinsic properties of cells explains the phenomenon of cluster formation.
Complete list of metadatas

Cited literature [25 references]  Display  Hide  Download

https://www.hal.inserm.fr/inserm-00149660
Contributor : Jean-Marie Zahm <>
Submitted on : Friday, June 15, 2007 - 3:20:29 PM
Last modification on : Wednesday, August 30, 2017 - 1:13:28 AM
Long-term archiving on: : Thursday, April 8, 2010 - 6:01:58 PM

Identifiers

  • HAL Id : inserm-00149660, version 1
  • PUBMED : 17543210

Collections

Citation

Jean-Marie Zahm, Salma Hazgui, Manuela Matos, Aadil Ben Seddik, Béatrice Nawrocki Raby, et al.. Quantitative videomicoscopic analysis of the sociologic behavior of non-invasive and invasive tumor cell lines: Sociologic behavior of cell lines. Cellular and Molecular Biology, 2007, 52 (6), pp.54-60. ⟨inserm-00149660⟩

Share

Metrics

Record views

690

Files downloads

377