D. Smith, F. Del-amo, F. Gridley, and T. , Isolation of Sna, a mouse gene homologous to the Drosophila genes snail and escargot: its expression pattern suggests multiple roles during postimplantation development, Development, vol.116, issue.14, pp.1033-1042, 1992.

K. Hemavathy, S. Ashraf, and Y. Ip, Snail/Slug family of repressors: slowly going into the fast lane of development and cancer, Gene, vol.257, issue.1, pp.1-12, 1992.
DOI : 10.1016/S0378-1119(00)00371-1

M. Nieto, M. Sargent, D. Wilkinson, and J. Cooke, Control of cell behavior during vertebrate development by Slug, a zinc finger gene) Nieto MA. The snail superfamily of zinc-finger transcription factors, Science Nat Rev Mol Cell Biol, vol.2643, issue.34, pp.835-9155, 1994.

A. Cano, M. Perez-moreno, R. I. Locascio, A. Blanco, M. Barrio et al., The transcription factor Snail controls epithelial???mesenchymal transitions by repressing E-cadherin expression, Nature Cell Biology, vol.51, issue.2, pp.76-83, 2000.
DOI : 10.1006/dbio.1998.9047

E. Batlle, E. Sancho, C. Franci, D. Dominguez, M. Monfar et al., The transcription factor Snail is a repressor of E-cadherin gene expression in epithelial tumour cells, Nature Cell Biology, vol.17, issue.2, pp.84-93, 2000.
DOI : 10.1083/jcb.111.3.1265

I. Poser, D. Dominguez, A. De-herreros, A. Varnai, R. Buettner et al., Loss of E-cadherin Expression in Melanoma Cells Involves Up-regulation of the Transcriptional Repressor Snail, Journal of Biological Chemistry, vol.276, issue.27, pp.24661-24667, 2001.
DOI : 10.1074/jbc.M011224200

K. Yokoyama, N. Kamata, E. Hayashi, T. Hoteiya, N. Ueda et al., Reverse correlation of E-cadherin and snail expression in oral squamous cell carcinoma cells in vitro, Oral Oncology, vol.37, issue.1, pp.65-71, 2001.
DOI : 10.1016/S1368-8375(00)00059-2

W. Jiao, K. Miyazaki, and Y. Kitajima, Inverse correlation between E-cadherin and Snail expression in hepatocellular carcinoma cell lines in vitro and in vivo, British Journal of Cancer, vol.14, issue.1, pp.98-101, 2002.
DOI : 10.1016/S1368-8375(00)00059-2

K. Hajra, D. Chen, and E. Fearon, The SLUG zinc-finger protein represses E-cadherin in breast cancer, Cancer Res, vol.62, issue.13, pp.1613-1621, 2002.

V. Bolos, H. Peinado, M. Perez-moreno, M. Fraga, M. Esteller et al., The transcription factor Slug represses E-cadherin expression and induces epithelial to mesenchymal transitions: a comparison with Snail and E47 repressors, Journal of Cell Science, vol.116, issue.3, pp.499-511, 2003.
DOI : 10.1242/jcs.00224

S. Chen, T. Itoh, K. Wu, D. Zhou, and C. Yang, Transcriptional regulation of aromatase expression in human breast tissue, The Journal of Steroid Biochemistry and Molecular Biology, vol.83, issue.1-5, pp.93-102, 2002.
DOI : 10.1016/S0960-0760(02)00276-5

K. Seki, T. Fujimori, P. Savagner, A. Hata, T. Aikawa et al., Mouse Snail Family Transcription Repressors Regulate Chondrocyte, Extracellular Matrix, Type II Collagen, and Aggrecan, Journal of Biological Chemistry, vol.278, issue.43, 2003.
DOI : 10.1074/jbc.M308336200
URL : https://hal.archives-ouvertes.fr/inserm-00148022

C. Espineda, J. Chang, J. Twiss, S. Rajasekaran, and A. Rajasekaran, Repression of Na,K-ATPase {beta}1-subunit by the transcription factor Snail in carcinoma, Mol Biol Cell, issue.17, 2003.

H. Peinado, E. Ballestar, M. Esteller, and A. Cano, Snail mediates E-cadherin repression by the recruitment of the Sin3A, HDAC1)/HDAC2 complex, pp.306-325, 2004.

E. Carver, R. Jiang, Y. Lan, K. Oram, and T. Gridley, The Mouse Snail Gene Encodes a Key Regulator of the Epithelial-Mesenchymal Transition, Molecular and Cellular Biology, vol.21, issue.23, pp.8184-8192, 2001.
DOI : 10.1128/MCB.21.23.8184-8188.2001

R. Jiang, Y. Lan, C. Norton, J. Sundberg, and T. Gridley, The slug gene is not essential for mesoderm or neural crest development in mice, Developmental Biology, vol.198, issue.2, pp.277-85, 1998.
DOI : 10.1016/S0012-1606(98)80005-5

P. Savagner, I. Karavanova, A. Perantoni, J. Thiery, and K. Yamada, Slug mRNA is expressed by specific mesodermal derivatives during rodent organogenesis, Developmental Dynamics, vol.172, issue.2, pp.182-189, 1998.
DOI : 10.1002/(SICI)1097-0177(199810)213:2<182::AID-AJA3>3.0.CO;2-C

C. Cheng, P. Wu, J. Yu, C. Huang, C. Yue et al., Mechanisms of inactivation of E-cadherin in breast carcinoma: modification of the two-hit hypothesis of tumor suppressor gene, Oncogene, vol.20, issue.29, pp.3814-3837, 2001.
DOI : 10.1038/sj.onc.1204505

M. Blanco, G. Moreno-bueno, D. Sarrio, A. Locascio, A. Cano et al., Correlation of Snail expression with histological grade and lymph node status in breast carcinomas, Oncogene, vol.21, issue.20, pp.3241-3247, 2002.
DOI : 10.1038/sj.onc.1205416

P. Kowalski, M. Rubin, and C. Kleer, E-cadherin expression in primary carcinomas of the breast and its distant metastases, Breast Cancer Research, vol.106, issue.6, pp.217-239, 2003.
DOI : 10.1002/ijc.11197

A. Demir, P. Groothuis, A. Nap, C. Punyadeera, A. De-goei et al., Menstrual effluent induces epithelial-mesenchymal transitions in mesothelial cells, Human Reproduction, vol.19, issue.1, pp.21-30, 2004.
DOI : 10.1093/humrep/deh042

A. Inoue, M. Seidel, W. Wu, S. Kamizono, A. Ferrando et al., Slug, a highly conserved zinc finger transcriptional repressor, protects hematopoietic progenitor cells from radiation-induced apoptosis in vivo, Cancer Cell, vol.2, issue.4, pp.279-88, 2002.
DOI : 10.1016/S1535-6108(02)00155-1

T. Okubo, T. Truong, B. Yu, T. Itoh, J. Zhao et al., Down-regulation of promoter 1.3 activity of the human aromatase gene in breast tissue by zinc-finger protein, snail (SnaH), Cancer Res, vol.15, pp.1338-1384, 2001.

I. Garcia, The radioresistance biological function of the SCF/kit signaling pathway is mediated by the zinc-finger transcription factor Slug, Oncogene, vol.22, pp.4205-4216, 2003.

J. Perez-losada, M. Sanchez-martin, A. Rodriguez-garcia, M. Sanchez, A. Orfao et al., Zinc-finger transcription factor Slug contributes to the function of the stem cell factor c-kit signaling pathway, Blood, vol.100, pp.1274-86, 2002.

M. Li, J. Aggeler, D. Farson, C. Hatier, J. Hassell et al., Influence of a reconstituted basement membrane and its components on casein gene expression and secretion in mouse mammary epithelial cells., Proceedings of the National Academy of Sciences, vol.84, issue.1, pp.136-176, 1987.
DOI : 10.1073/pnas.84.1.136

Q. Petersen, L. Ronnov-jessen, A. Howlett, and M. Bissel, Interaction with basement membrane serves to rapidly distinguish growth and differentiation pattern of normal and malignant human breast epithelial cells., Proceedings of the National Academy of Sciences, vol.89, issue.19, pp.9064-9072, 1992.
DOI : 10.1073/pnas.89.19.9064

L. Larue, . Om, J. Hirchenhain, and R. Kemler, E-cadherin null mutant embryos fail to form a trophectoderm epithelium., Proceedings of the National Academy of Sciences, vol.91, issue.17, pp.8263-8270, 1994.
DOI : 10.1073/pnas.91.17.8263

G. Berx and F. Van-roy, The E-cadherin/catenin complex: an important gatekeeper in breast cancer tumorigenesis and malignant progression, Breast Cancer Research, vol.7, issue.5, pp.289-93, 2001.
DOI : 10.1016/S1097-2765(01)00260-X

N. Hunt, D. , A. Jasani, B. Morgan, J. Pignatelli et al., Loss of E-cadherin expression associated with lymph node metastases in small breast carcinomas, Virchows Archiv, vol.176, issue.4, pp.285-294, 1997.
DOI : 10.1007/BF01092751

K. Asgeirsson, J. Jónasson, L. Tryggvadóttir, K. Ólafsdóttir, J. Sigurgeirsdóttir et al., Altered expression of E-cadherin in breast cancer: patterns, mechanisms and clinical significance, European Journal of Cancer, vol.35, pp.1098-106, 2000.
DOI : 10.1016/S0959-8049(99)80730-8

S. Gupta, D. , A. Jasani, B. Morgan, J. Pignatelli et al., E-Cadherin (E-cad) expression in duct carcinoma in situ (DCIS) of the breast, Virchows Archiv, vol.28, issue.1, pp.23-31, 1997.
DOI : 10.1007/BF01008012

C. Gamallo, J. Palacios, A. Suarez, A. Pizarro, P. Navarro et al., Correlation of E-cadherin expression with differentiation grade and histological type in breast carcinoma, Am J Pathol, vol.142, issue.38, pp.987-93, 1993.

C. Parker, R. Rampaul, S. Pinder, J. Bell, P. Wencyk et al., E-cadherin as a prognostic indicator in primary breast cancer, British Journal of Cancer, vol.85, issue.12, pp.1958-63, 2001.
DOI : 10.1054/bjoc.2001.2178

P. Lipponen, E. Saarelainen, H. Ji, S. Aaltomaa, and K. Syrjanen, Expression of E-cadherin (E-CD) as related to other prognostic factors and survival in breast cancer, The Journal of Pathology, vol.110, issue.2, pp.101-110, 1994.
DOI : 10.1002/path.1711740206

H. Oka, H. Shiozaki, K. Kobayashi, M. Inoue, H. Tahara et al., Expression of E-cadherin cell adhesion molecules in human breast cancer tissues and its relationship to metastasis, Cancer Res, vol.53, issue.41, pp.1696-701, 1993.

C. Daniel, P. Strickland, and Y. Friedmann, Expression and Functional Role of E- and P-Cadherins in Mouse Mammary Ductal Morphogenesis and Growth, Developmental Biology, vol.169, issue.2, pp.511-520, 1995.
DOI : 10.1006/dbio.1995.1165

A. Perl, P. Wilgenbus, U. Dahl, H. Semb, and G. Christofori, A causal role for E-cadherin in the transition from adenoma to carcinoma, Nature, vol.10, issue.6672, pp.190-193, 1998.
DOI : 10.1038/32433

J. Reis-filho, C. Paredes, J. Milanezi, F. Schmitt, and F. , Clinicopathologic implications of E-cadherin reactivity in patients with lobular carcinoma in situ of the breast, Cancer, vol.4494, pp.2114-2119, 2002.

Y. Kanai, T. Oda, H. Tsuda, A. Ochiai, and S. Hirohashi, Point Mutation of the E-Cadherin Gene in Invasive Lobular Carcinoma of the Breast, Japanese Journal of Cancer Research, vol.51, issue.10, pp.1035-1044, 1994.
DOI : 10.1111/j.1349-7006.1994.tb02902.x

C. Huiping, J. Sigurgeirsdottir, J. Jonasson, G. Eiriksdottir, J. Johannsdottir et al., Chromosome alterations and E-cadherin gene mutations in human lobular breast cancer, British Journal of Cancer, vol.81, issue.7, pp.1103-1113, 1999.
DOI : 10.1038/sj.bjc.6690815

H. Lei, S. Sjoberg-margolin, S. Salahshor, B. Werelius, E. Jandakova et al., mutations are present in both ductal and lobular breast cancer, but promoter allelic variants show no detectable breast cancer risk, International Journal of Cancer, vol.11, issue.2, pp.199-204, 2002.
DOI : 10.1002/ijc.10176

G. Berx, A. Cleton-jansen, K. Strumane, W. De-leeuw, F. Nollet et al., Ecadherin is inactivated in a majority of invasive human lobular breast cancers by truncation mutations throughout its extracellular domain, Oncogene, vol.13, issue.48, pp.1919-1944, 1996.

I. Bukholm, J. Nesland, and A. Borresen-dale, Re-expression of E-cadherin, ?-catenin and ?-catenin, but not of ?-catenin, in metastatic tissue from breast cancer patients, The Journal of Pathology, vol.22, issue.1, pp.15-24, 2000.
DOI : 10.1002/(SICI)1096-9896(200001)190:1<15::AID-PATH489>3.0.CO;2-L

J. Graff, J. Herman, R. Lapidus, H. Chopra, R. Xu et al., E-cadherin expression is silenced by DNA hypermethylation in human breast and prostate carcinomas, Cancer Res, vol.55, pp.5195-5204, 1995.

G. Hennig, O. Lowrick, W. Birchmeier, and J. Behrens, Mechanisms identified in the transcriptional control of epithelial gene expression, J Biol Chem, vol.271, pp.595-602, 1996.

E. Batsche, C. Muchardt, J. Behrens, H. Hurst, and C. Cremisi, RB and c-Myc Activate Expression of the E-Cadherin Gene in Epithelial Cells through Interaction with Transcription Factor AP-2, Molecular and Cellular Biology, vol.18, issue.7, pp.3647-58, 1998.
DOI : 10.1128/MCB.18.7.3647

P. Miettinen, R. Ebner, A. Lopez, and R. Derynck, TGF-beta induced transdifferentiation of mammary epithelial cells to mesenchymal cells: involvement of type I receptors, The Journal of Cell Biology, vol.127, issue.6, pp.2021-2057, 1994.
DOI : 10.1083/jcb.127.6.2021

S. Hosono, I. Gross, M. English, K. Hajra, E. Fearon et al., E-cadherin Is a WT1 Target Gene, Journal of Biological Chemistry, vol.275, issue.15, pp.10943-53, 2000.
DOI : 10.1074/jbc.275.15.10943

C. Tan, P. Costello, J. Sanghera, D. Dominguez, J. Baulida et al., Inhibition of integrin linked kinase (ILK) suppresses ??-catenin-Lef/Tcf-dependent transcription and expression of the E-cadherin repressor, snail, in APC???/??? human colon carcinoma cells, Oncogene, vol.20, issue.1, pp.133-173, 2001.
DOI : 10.1038/sj.onc.1204052

). Souza, B. Taylor-papadimitriou, and J. , Overexpression of ERBB2 in human mammary epithelial cells signals inhibition of transcription of the E-cadherin gene., Proceedings of the National Academy of Sciences, vol.91, issue.15, pp.7202-7208, 1994.
DOI : 10.1073/pnas.91.15.7202

J. Comijn, G. Berx, P. Vermassen, K. Verschueren, L. Van-grunsven et al., The Two-Handed E Box Binding Zinc Finger Protein SIP1 Downregulates E-Cadherin and Induces Invasion, Molecular Cell, vol.7, issue.6, pp.1267-78, 2001.
DOI : 10.1016/S1097-2765(01)00260-X

K. Yokoyama, N. Kamata, R. Fujimoto, S. Tsutsumi, M. Tomonari et al., Increased invasion and matrix metalloproteinase-2 expression by Snail-induced mesenchymal transition in squamous cell carcinomas, International Journal of Oncology, vol.22, issue.59, pp.891-899, 2003.
DOI : 10.3892/ijo.22.4.891

O. Prall, . Re, and R. Sutherland, Estrogen regulation of cell cycle progression in breast cancer cells, The Journal of Steroid Biochemistry and Molecular Biology, vol.65, issue.1-6, pp.169-74, 1998.
DOI : 10.1016/S0960-0760(98)00021-1

S. Masood, Immunocytochemical localization of estrogen and progesterone receptors in imprint preparations of breast carcinomas, Cancer, vol.205, issue.8, pp.2109-2123, 1992.
DOI : 10.1002/1097-0142(19921015)70:8<2109::AID-CNCR2820700817>3.0.CO;2-C

S. Chen, D. Zhou, C. Yang, T. Okubo, Y. Kinoshita et al., Modulation of aromatase expression in human breast tissue, The Journal of Steroid Biochemistry and Molecular Biology, vol.79, issue.1-5, pp.35-40, 2001.
DOI : 10.1016/S0960-0760(01)00132-7

V. James, J. Mcneill, L. Lai, C. Newton, M. Ghilchik et al., Aromatase activity in normal breast and breast tumor tissues: In vivo and in vitro studies, Steroids, vol.50, issue.1-3, pp.269-79, 1987.
DOI : 10.1016/0039-128X(83)90077-6

S. Chen, D. Zhou, T. Okubo, Y. Kao, E. Eng et al., Prevention and Treatment of Breast Cancer by Suppressing Aromatase Activity and Expression, Annals of the New York Academy of Sciences, vol.61, issue.Pt. 1, pp.229-267, 2002.
DOI : 10.1111/j.1749-6632.2002.tb04115.x

N. Fujita, D. Jaye, M. Kajita, C. Geigerman, C. Moreno et al., MTA3, a Mi-2/NuRD Complex Subunit, Regulates an Invasive Growth Pathway in Breast Cancer, Cell, vol.113, issue.2, pp.207-226, 2003.
DOI : 10.1016/S0092-8674(03)00234-4

D. Salomon, R. Brandt, F. Ciardiello, and N. Normanno, Epidermal growth factor-related peptides and their receptors in human malignancies, Critical Reviews in Oncology/Hematology, vol.19, issue.3, pp.183-232, 1995.
DOI : 10.1016/1040-8428(94)00144-I

B. Boyer, S. Roche, M. Denoyelle, and J. Thiery, Src and Ras are involved in separate pathways in epithelial cell scattering, The EMBO Journal, vol.16, issue.19, pp.5904-5917, 1997.
DOI : 10.1093/emboj/16.19.5904

Z. Lu, S. Ghosh, Z. Wang, and T. Hunter, Downregulation of caveolin-1 function by EGF leads to the loss of E-cadherin, increased transcriptional activity of ??-catenin, and enhanced tumor cell invasion, Cancer Cell, vol.4, issue.6, pp.499-515, 2003.
DOI : 10.1016/S1535-6108(03)00304-0

R. Schmidt-ullrich, R. Mikkelsen, P. Dent, D. Todd, K. Valerie et al., Radiation-induced proliferation of the human A431 squamous carcinoma cells is dependent on EGFR tyrosine phosphorylation, Oncogene, vol.15, issue.10, pp.1191-1198, 1997.
DOI : 10.1038/sj.onc.1201275

S. Hines, C. Organ, M. Kornstein, and G. Krystal, Coexpression of the c-kit and stem cell factor genes in breast carcinomas, Cell Growth Differ, vol.6, pp.769-79, 1995.