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Mammalian transforming growth factor-betas: Smad signaling and physio-pathological roles.

Abstract : Since its discovery in the early 1980s, transforming growth factor-beta (TGF-beta) has emerged as a family of growth factors involved in essential physiological processes, including embryonic development, differentiation, tissue repair and cell growth control. Knockout experiments for the three mammalian isoforms of TGF-betas in mice have demonstrated their importance in regulating inflammation and tissue repair. Also, TGF-beta has been implicated in the pathogenesis of human diseases, including tissue fibrosis and carcinogenesis where, in the latter case, it may exert both tumor suppressor and pro-oncogenic activities depending on the stage of the tumor. Cellular signaling by TGF-beta family members is initiated by the assembly of specific cell surface serine/threonine kinase type receptors that activate transcription factors of the Smad family.
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Submitted on : Monday, May 21, 2007 - 2:20:29 PM
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Delphine Javelaud, Alain Mauviel. Mammalian transforming growth factor-betas: Smad signaling and physio-pathological roles.. International Journal of Biochemistry and Cell Biology, Elsevier, 2004, 36 (7), pp.1161-5. ⟨10.1016/S1357-2725(03)00255-3⟩. ⟨inserm-00147457⟩

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