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[Transforming growth factor-betas: smad signaling and roles in physiopathology]

Abstract : Transforming growth factor-beta (TGF-beta) family members are multifunctional peptide growth factors that regulate cell growth, differentiation, extracellular matrix production and cell migration and embryonic development. Knock-out experiments for the three mammalian isoforms of TGF-beta in mice have demonstrated their importance in regulating inflammation and tissue repair. Also, TGF-beta has been implicated in the pathogenesis of human diseases, including tissue fibrosis and carcinogenesis. In the latter case, it may exert both tumor suppressor and pro-oncogenic activities depending on the stage of the tumor. Smads proteins constitute the core components of the intracellular signaling cascade initiated by TGF-beta receptors, as they carry signals from the cell surface directly to the nucleus; where they act as transcription factors.
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https://www.hal.inserm.fr/inserm-00147403
Contributor : Alain Mauviel <>
Submitted on : Monday, May 21, 2007 - 12:55:10 PM
Last modification on : Monday, May 21, 2007 - 12:55:10 PM
Long-term archiving on: : Wednesday, April 7, 2010 - 1:22:48 AM

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Delphine Javelaud, Alain Mauviel. [Transforming growth factor-betas: smad signaling and roles in physiopathology]. Pathologie Biologie, Elsevier Masson, 2004, 52 (1), pp.50-4. ⟨10.1016/j.patbio.2003.10.002⟩. ⟨inserm-00147403⟩

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