TGF-beta-induced SMAD signaling and gene regulation: consequences for extracellular matrix remodeling and wound healing. - Inserm - Institut national de la santé et de la recherche médicale Accéder directement au contenu
Article Dans Une Revue Journal of Dermatological Science Année : 2004

TGF-beta-induced SMAD signaling and gene regulation: consequences for extracellular matrix remodeling and wound healing.

Résumé

Members of the transforming growth factor-beta (TGF-beta) superfamily are pleiotropic cytokines that have the ability to regulate numerous cell functions, including proliferation, differentiation, apoptosis, epithelial-mesenchymal transition, and production of extracellular matrix, allowing them to play an important role during embryonic development and for maintenance of tissue homeostasis. Three TGF-beta isoforms have been identified in mammals. They propagate their signal via a signal transduction network involving receptor serine/threonine kinases at the cell surface and their substrates, the SMAD proteins. Upon phosphorylation and oligomerization, the latter move into the nucleus to regulate transcription of target genes. This review will summarize recent advances in the understanding of the mechanisms underlying SMAD modulation of extracellular matrix gene expression in the context of wound healing and tissue fibrosis.
Fichier principal
Vignette du fichier
JDS_review_03135_revised.pdf (194.19 Ko) Télécharger le fichier
Fig1.ppt (59.5 Ko) Télécharger le fichier
Fig2.ppt (33 Ko) Télécharger le fichier
Fig3.ppt (51.5 Ko) Télécharger le fichier
Format : Autre
Format : Autre
Format : Autre
Loading...

Dates et versions

inserm-00147401 , version 1 (21-05-2007)

Identifiants

Citer

Meinhard Schiller, Delphine Javelaud, Alain Mauviel. TGF-beta-induced SMAD signaling and gene regulation: consequences for extracellular matrix remodeling and wound healing.. Journal of Dermatological Science, 2004, 35 (2), pp.83-92. ⟨10.1016/j.jdermsci.2003.12.006⟩. ⟨inserm-00147401⟩

Collections

INSERM
139 Consultations
1541 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More