Skip to Main content Skip to Navigation
Journal articles

A novel isoform of delta-sarcoglycan is localized at the sarcoplasmic reticulum of mouse skeletal muscle.

Abstract : The sarcoglycan-sarcospan complex (alpha-, beta-, gamma-, delta-, epsilon-, and zeta-SG-SSPN), a component of the dystrophin-associated glycoprotein complex (DAGC), is located at the sarcolemma of muscle fibers where it contributes to maintain cell integrity during contraction-relaxation cycles; gamma- and delta-SG are also expressed in the sarcoplasmic reticulum (SR). In this study, we report the identification of a novel isoform of murine delta-SG produced by alternative splicing that we named delta-SG3. This isoform is present at transcript level in several tissues, with its highest expression in skeletal and cardiac muscle. The delta-SG3 protein lacks the last 122 amino acids at the C-terminal, which are replaced by 10 new amino acids (EGFLNMQLAG). Interestingly, double immunofluorescence analysis for delta-SG3 and the dihydropyridine receptor (DHPR) shows a close localization of these two proteins. We propose the subcellular distribution of this novel delta-SG3 isoform at the SR and its involvement in intracellular calcium concentration regulation.
Document type :
Journal articles
Complete list of metadatas

Cited literature [26 references]  Display  Hide  Download

https://www.hal.inserm.fr/inserm-00147315
Contributor : Dominique Mornet <>
Submitted on : Wednesday, May 16, 2007 - 4:23:08 PM
Last modification on : Friday, March 27, 2020 - 9:20:05 AM
Long-term archiving on: : Wednesday, April 7, 2010 - 3:38:01 AM

Identifiers

Citation

Francisco Estrada, Dominique Mornet, Haydeé Rosas-Vargas, Alexandra Angulo, Manuel Hernández, et al.. A novel isoform of delta-sarcoglycan is localized at the sarcoplasmic reticulum of mouse skeletal muscle.. Biochemical and Biophysical Research Communications, Elsevier, 2006, 340 (3), pp.865-71. ⟨10.1016/j.bbrc.2005.12.083⟩. ⟨inserm-00147315⟩

Share

Metrics

Record views

325

Files downloads

831