P. Mcgeer and E. Mcgeer, The inflammatory response system of brain: implications for therapy of Alzheimer and other neurodegenerative diseases, Brain Research Reviews, vol.21, issue.2, pp.195-218, 1995.
DOI : 10.1016/0165-0173(95)00011-9

D. Levy and S. Lipton, Comparison of delayed administration of competitive and uncompetitive antagonists in preventing NMDA receptor-mediated neuronal death, Neurology, vol.40, issue.5, pp.852-855, 1990.
DOI : 10.1212/WNL.40.5.852

P. Matini, F. Moroni, G. Lombardi, M. Faussone-pellegrini, and F. Moroni, Ultrastructural and Biochemical Studies on the Neuroprotective Effects of Excitatory Amino Acid Antagonists in the Ischemic Rat Retina, Experimental Neurology, vol.146, issue.2, pp.419-434, 1997.
DOI : 10.1006/exnr.1997.6546

T. Lam, A. Abler, J. Kwong, and M. Tso, N-methyl-D-aspartate (NMDA)?induced apoptosis in rat retina, Invest Ophthalmol Vi Sci, vol.40, pp.2391-2397, 1999.

S. Manabe and S. Lipton, Divergent NMDA Signals Leading to Proapoptotic and Antiapoptotic Pathways in the Rat Retina, Investigative Opthalmology & Visual Science, vol.44, issue.1, pp.385-392, 2003.
DOI : 10.1167/iovs.02-0187

L. Kerrigan, D. Zack, H. Quigley, S. Smith, and M. Pease, TUNEL-Positive Ganglion Cells in Human Primary Open-angle Glaucoma, Archives of Ophthalmology, vol.115, issue.8, pp.1031-1035, 1997.
DOI : 10.1001/archopht.1997.01100160201010

H. Quigley, R. Nickells, L. Kerrigan, M. Pease, D. Thibault et al., Retinal ganglion cell death in experimental glaucoma and after axotomy occurs by apoptosis, Invest Ophthalmol Vis Sci, vol.36, pp.774-786, 1995.

S. Koponen, K. Kurkinen, K. Akerman, P. Mochly-rosen, and J. Koistinaho, Prevention of NMDA-induced death of cortical neurons by inhibition of protein kinase C??, Journal of Neurochemistry, vol.96, issue.2, pp.442-452, 2003.
DOI : 10.1046/j.1471-4159.2003.01846.x

M. Grilli, M. Pizzi, M. Memo, and P. Spano, Neuroprotection by Aspirin and Sodium Salicylate Through Blockade of NF-kappa B Activation, Science, vol.274, issue.5291, pp.1383-1385, 1996.
DOI : 10.1126/science.274.5291.1383

D. Cristobal, J. Cardenas, A. Lizasoain, and I. , Inhibition of Glutamate Release via Recovery of ATP Levels Accounts for a Neuroprotective Effect of Aspirin in Rat Cortical Neurons Exposed to Oxygen-Glucose Deprivation, Stroke, vol.33, issue.1, pp.261-267, 2002.
DOI : 10.1161/hs0102.101299

L. Fernandez, Neuroprotection by aspirin in cerebrovascular pathology, Ann R Acad Nac Med (Madr.), vol.119, pp.311-320, 2002.

N. Vartiainen, V. Keksas-goldsteine, G. Goldsteins, and J. Koistinaho, Aspirin provides cyclin-dependent kinase???5-dependent protection against subsequent hypoxia/reoxygenation damage in culture, Journal of Neurochemistry, vol.26, issue.2, pp.329-335, 2002.
DOI : 10.1046/j.1471-4159.2002.00959.x

N. Vartiainen, G. Goldsteins, V. Keksa-goldsteine, P. Chan, and J. Koistinaho, Aspirin Inhibits p44/42 Mitogen-Activated Protein Kinase and Is Protective Against Hypoxia/Reoxygenation Neuronal Damage, Stroke, vol.34, issue.3, pp.752-757, 2003.
DOI : 10.1161/01.STR.0000057813.31798.1F

R. Minchin, I. Illet, C. Teitel, P. Reeves, and F. Kadlubar, -hydroxy arylamines by acetylsalicylic acid to form carcinogen-DNA adducts, Carcinogenesis, vol.13, issue.4, pp.663-667, 1992.
DOI : 10.1093/carcin/13.4.663
URL : https://hal.archives-ouvertes.fr/hal-00807554

T. Hirai and K. Chida, Protein Kinase Czeta (PKCzeta): Activation Mechanisms and Cellular Functions, Journal of Biochemistry, vol.133, issue.1, pp.1-7, 2003.
DOI : 10.1093/jb/mvg017

A. Duran, M. Diaz-meco, and J. Moscat, Essential role of RelA Ser311 phosphorylation by ??PKC in NF-??B transcriptional activation, The EMBO Journal, vol.22, issue.15, pp.3910-3918, 2003.
DOI : 10.1093/emboj/cdg370

S. Savkovic, A. Koutsouris, and G. Hecht, PKC?? participates in activation of inflammatory response induced by enteropathogenic E. coli, AJP: Cell Physiology, vol.285, issue.3, pp.512-521, 2003.
DOI : 10.1152/ajpcell.00444.2002

Y. Nishizuka, Protein kinase C and lipid signaling for sustained cellular responses, FASEB J, vol.9, pp.484-496, 1995.

A. Newton, Regulation of the ABC kinases by phosphorylation: protein kinase C as a paradigm, Biochemical Journal, vol.370, issue.2, pp.361-371, 2003.
DOI : 10.1042/bj20021626

Y. Ono, T. Fujii, K. Ogita, U. Kikkawa, K. Igarashi et al., Protein kinase C zeta subspecies from rat brain: its structure, expression, and properties., Proceedings of the National Academy of Sciences, vol.86, issue.9, pp.3099-3103, 1989.
DOI : 10.1073/pnas.86.9.3099
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC287072

H. Nakanishi and J. Exton, Purification and characterization of the zeta isoform of protein kinase C from bovine kidney, J Biol Chem, vol.267, pp.16347-16354, 1992.

H. Nakanishi, K. Brewer, and J. Exton, Activation of the zeta isozyme of protein kinase C by phosphatidylinositol 3,4,5- trisphosphate, J Biol Chem, vol.268, pp.13-16, 1993.

G. Muller, M. Ayoub, P. Storz, J. Rennecke, D. Fabbro et al., PKC zeta is a molecular switch in signal transduction of TNFalpha , bifunctionally regulated by ceramide and arachidonic acid, EMBO J, vol.14, pp.1961-1969, 1995.

Y. Wang, M. Seibenhener, M. Vanderplas, and M. Wooten, Atypical PKC ?? is activated by ceramide, resulting in coactivation of NF-??b/JNK kinase and cell survival, Journal of Neuroscience Research, vol.6, issue.3, pp.293-302, 1999.
DOI : 10.1002/(SICI)1097-4547(19990201)55:3<293::AID-JNR4>3.0.CO;2-9

M. Calcerrada, B. Miguel, L. Martin, R. Catalan, and A. Martinez, Involvement of phosphatidylinositol 3-kinase in nuclear translocation of protein kinase C ?? induced by C2-ceramide in rat hepatocytes, FEBS Letters, vol.13, issue.2-3, pp.361-365, 2002.
DOI : 10.1016/S0014-5793(02)02401-8

M. Wooten, G. Zhou, M. Wooten, and M. Seibenhener, Transport of protein kinase C isoforms to the nucleus of PC12 cells by nerve growth factor: Association of atypical ?-PKC with the nuclear matrix, Journal of Neuroscience Research, vol.49, issue.4, pp.393-403, 1997.
DOI : 10.1002/(SICI)1097-4547(19970815)49:4<393::AID-JNR1>3.0.CO;2-3

W. White, M. Seibenheiner, and M. Wooten, Phosphorylation of tyrosine 256 facilitates nuclear import of atypical protein kinase C, Journal of Cellular Biochemistry, vol.272, issue.24, pp.42-53, 2002.
DOI : 10.1002/jcb.10101

L. Neri, A. Martelli, P. Borgatti, M. Colamussi, M. Marchisio et al., Increase in nuclear phosphatidylinositol 3-kinase activity and phosphatidylinositol (3,4,5) trisphosphate synthesis precede PKC-zeta translocation to the nucleus of NGF treated PC12 cells, FASEB J, vol.13, pp.2299-2310, 1999.

A. Kishimoto, N. Kajikawa, M. Shiota, and Y. Nishizuka, Proteolytic activation of calcium-activated, phospholipid-dependent protein kinase by calcium-dependent neutral protease, J Biol Chem, vol.258, pp.1156-1164, 1983.

Y. Takai, A. Kishimoto, M. Inoue, and Y. Nishizuka, Studies on a cyclic nucleotide-independent protein kinase and its proenzyme in mammalian tissues. I. Purification and characterization of an active enzyme from bovine cerebellum, J Biol Chem, vol.252, pp.7603-7609, 1977.

S. Frutos, J. Moscat, and M. Diaz-meco, Cleavage of ??PKC but Not ??/??PKC by Caspase-3 during UV-induced Apoptosis, Journal of Biological Chemistry, vol.274, issue.16, pp.10765-10770, 1999.
DOI : 10.1074/jbc.274.16.10765

L. Smith, L. Chen, and M. Reyland, Activation of Atypical Protein Kinase C zeta by Caspase Processing and Degradation by the Ubiquitin-Proteasome System, Journal of Biological Chemistry, vol.275, issue.51, pp.40620-40627, 2000.
DOI : 10.1074/jbc.M908517199

P. Crisanti, L. A. Lim, D. Omri, and B. , Aspirin prevention of NMDA-induced neuronal death by direct protein kinase C?? inhibition, Journal of Neurochemistry, vol.22, issue.6, pp.1587-1593, 2005.
DOI : 10.1111/j.1471-4159.2005.03157.x

S. Hrabetova and T. Sacktor, Bidirectional regulation of protein kinase M zeta in the maintenance of long-term potentiation and long-term depression, J Neurosci, vol.16, pp.5324-5333, 1996.

A. Hernandez, N. Blace, and J. Crary, Protein Kinase M?? Synthesis from a Brain mRNA Encoding an Independent Protein Kinase C?? Catalytic Domain: IMPLICATIONS FOR THE MOLECULAR MECHANISM OF MEMORY, Journal of Biological Chemistry, vol.278, issue.41, pp.40305-40316, 2003.
DOI : 10.1074/jbc.M307065200

B. Marshall, G. Price, and C. Powel, Rat Protein Kinase C Zeta Gene Contains Alternative Promoters for Generation of Dual Transcripts with 5???-End Heterogeneity, DNA and Cell Biology, vol.19, issue.12, pp.707-719, 2000.
DOI : 10.1089/104454900750058071

S. Tan and P. Parker, Emerging and diverse roles of protein kinase C in immune cell signalling, Biochemical Journal, vol.376, issue.3, pp.545-552, 2003.
DOI : 10.1042/bj20031406

M. Mikati, R. Abi-habib, E. Sabban, and M. , Hippocampal Programmed Cell Death after Status Epilepticus: Evidence for NMDA-Receptor and Ceramide-Mediated???Mechanisms, Epilepsia, vol.23, issue.suppl 6, pp.282-291, 2003.
DOI : 10.1046/j.1528-1157.2003.22502.x

G. Wang, J. Silva, K. Krishnamurthy, E. Tran, B. Condie et al., Direct Binding to Ceramide Activates Protein Kinase C?? before the Formation of a Pro-apoptotic Complex with PAR-4 in Differentiating Stem Cells, Journal of Biological Chemistry, vol.280, issue.28, pp.26415-26424, 2005.
DOI : 10.1074/jbc.M501492200

L. Smith, Z. Wang, and J. Smith, Caspase processing activates atypical protein kinase C ?? by relieving autoinhibition and destabilizes the protein, Biochemical Journal, vol.375, issue.3, pp.663-671, 2003.
DOI : 10.1042/bj20030926

G. Zhou, M. Seibenhener, and M. Wooten, Nucleolin Is a Protein Kinase C-?? Substrate: CONNECTION BETWEEN CELL SURFACE SIGNALING AND NUCLEUS IN PC12 CELLS, Journal of Biological Chemistry, vol.272, issue.49, pp.31130-31137, 1997.
DOI : 10.1074/jbc.272.49.31130

M. Vandenplas, V. Mamidipudi, L. Seibenhener, M. Wooten, and M. , Nerve growth factor activates kinases that phosphorylate atypical protein kinase C, Cellular Signalling, vol.14, issue.4, pp.359-363, 2002.
DOI : 10.1016/S0898-6568(01)00261-3

Y. Mizukami, T. Hirata, and K. Yoshida, Nuclear translocation of PKC?? during ischemia and its inhibition by wortmannin, an inhibitor of phosphatidylinositol 3-kinase, FEBS Letters, vol.401, issue.2-3, pp.247-251, 1997.
DOI : 10.1016/S0014-5793(96)01481-0

M. Pizzi, F. Goffi, and F. Boroni, Opposing Roles for NF-??B/Rel Factors p65 and c-Rel in the Modulation of Neuron Survival Elicited by Glutamate and Interleukin-1??, Journal of Biological Chemistry, vol.277, issue.23, pp.20717-20723, 2002.
DOI : 10.1074/jbc.M201014200

Y. Kitaoka, T. Kumai, and Y. Kitaoka, Nuclear factor-kappa B p65 in NMDA-induced retinal neurotoxicity, Molecular Brain Research, vol.131, issue.1-2, pp.8-16, 2004.
DOI : 10.1016/j.molbrainres.2004.07.021

Y. Yamamoto and R. Gaynor, Therapeutic potential of inhibition of the NF-??B pathway in the treatment of inflammation and cancer, Journal of Clinical Investigation, vol.107, issue.2, pp.135-142, 2001.
DOI : 10.1172/JCI11914

S. Fiorucci, L. Santucci, and L. Wallacej, Interaction of a selective cyclooxygenase-2 inhibitor with aspirin and NO-releasing aspirin in the human gastric mucosa, Proceedings of the National Academy of Sciences, vol.285, issue.3, pp.10937-10941, 2003.
DOI : 10.1016/S0378-4347(97)00539-2

M. Pique, M. Barragan, M. Dalmaub, B. Bellosillo, G. Pons et al., release, FEBS Letters, vol.2, issue.2-3, pp.193-196, 2000.
DOI : 10.1016/S0014-5793(00)01922-0

F. Lloyd, . Jr, V. Slivova, T. Valachovicova, and D. Sliva, Aspirin inhibits highly invasive prostate cancer cells, International Journal of Oncology, vol.23, pp.1277-1283, 2003.
DOI : 10.3892/ijo.23.5.1277

S. Hewett, T. Uliasz, A. Vidwans, and J. Hewett, Cyclooxygenase- 2 contributes to N-methyl-D-aspartate-mediated neuronal cell death in primary cortical cell culture, J Pharmacol Exp Ther, vol.293, pp.417-425, 2000.

M. Pillinger, C. Capodici, and P. Rosenthal, Modes of action of aspirin-like drugs: Salicylates inhibit Erk activation and integrin-dependent neutrophil adhesion, Proceedings of the National Academy of Sciences, vol.272, issue.37, pp.14540-14545, 1998.
DOI : 10.1074/jbc.272.37.23448