Skip to Main content Skip to Navigation
Journal articles

The role of PKCzeta in amikacin-induced apoptosis in the cochlea: prevention by aspirin.

Abstract : Aminoglycoside antibiotics are ototoxic, inducing irreversible sensorineural hearing loss mediated by oxidative and excitotoxic stresses. The NF-kappaB pathway is involved in the response to aminoglycoside damage in the cochlea. However, the molecular mechanisms of this ototoxicity remain unclear. We investigated the expression of PKCzeta, a key regulator of NF-kappaB activation, in response to aminoglycoside treatment. Amikacin induced PKCzeta cleavage and nuclear translocation. These events were concomitant with chromatin condensation and paralleled the decrease in NF-kappaB (p65) levels in the nucleus. Amikacin also induced the nuclear translocation of apoptotic inducing factor (AIF). Prior treatment with aspirin prevented PKCzeta cleavage and nuclear translocation. Thus, aspirin counteracts the early effects of amikacin, thereby protecting hair cells and spiral ganglion neurons. These results demonstrate that PKCzeta acts as sentinel connecting specific survival pathways to mediate cellular responses to amikacin ototoxicity.
Complete list of metadatas

Cited literature [68 references]  Display  Hide  Download

https://www.hal.inserm.fr/inserm-00146708
Contributor : Patricia Crisanti Lassiaz <>
Submitted on : Tuesday, May 15, 2007 - 11:37:22 AM
Last modification on : Wednesday, August 19, 2020 - 11:16:51 AM
Long-term archiving on: : Friday, November 25, 2016 - 3:31:55 PM

File

 Restricted access
To satisfy the distribution rights of the publisher, the document is embargoed until : jamais

Please log in to resquest access to the document

Identifiers

Collections

Citation

Eric Lecain, Boubaker Omri, Francine Behar-Cohen, Patrice Tran Ba Huy, Patricia Crisanti. The role of PKCzeta in amikacin-induced apoptosis in the cochlea: prevention by aspirin.. Apoptosis, Springer Verlag, 2007, 12 (2), pp.333-42. ⟨10.1007/s10495-006-0580-0⟩. ⟨inserm-00146708⟩

Share

Metrics

Record views

360