J. Chang and D. Wakefield, Uveitis: a global perspective, Ocular Immunology and Inflammation, vol.67, issue.1, pp.263-279, 2002.
DOI : 10.1076/ocii.

J. Rosenbaum, H. Mcdevitt, R. Guss, and P. Egbert, Endotoxin-induced uveitis in rats as a model for human disease, Nature, vol.84, issue.5773, pp.611-613, 1980.
DOI : 10.1038/286611a0

R. Hoekzema, C. Verhagen, M. Van-haren, and A. Kijlstra, Endotoxin-induced uveitis in the rat: the significance of intraocular interleukin-6, Invest Ophthalmol Vis Sci, vol.33, pp.532-539, 1992.

J. Ruiz-moreno, B. Thillaye, and Y. De-kozak, Retino-Choroidal Changes in Endotoxin-Induced Uveitis in the Rat, Ophthalmic Research, vol.24, issue.3, pp.162-168, 1992.
DOI : 10.1159/000267163

J. Luna, C. Chan, N. Derevjanik, J. Mahlow, C. Chiu et al., Blood-retinal barrier (BRB) breakdown in experimental autoimmune uveoretinitis: Comparison with vascular endothelial growth factor, tumor necrosis factor ?, and interleukin-1?-mediated breakdown, Journal of Neuroscience Research, vol.49, issue.3, pp.268-280, 1997.
DOI : 10.1002/(SICI)1097-4547(19970801)49:3<268::AID-JNR2>3.0.CO;2-A

S. Planck, X. Huang, J. Robertson, and J. Rosenbaum, Cytokine mRNA levels in rat ocular tissues after systemic endotoxin treatment, Invest Ophthalmol Vis Sci, vol.35, pp.924-930, 1994.

Y. De-kozak, M. Naud, J. Bellot, J. Faure, and D. Hicks, Differential tumor necrosis factor expression by resident retinal cells from experimental uveitis-susceptible and -resistant rat strains, Journal of Neuroimmunology, vol.55, issue.1, pp.1-9, 1994.
DOI : 10.1016/0165-5728(94)90141-4

A. De-vos, V. Klaren, and A. Kijlstra, Expression of multiple cytokines and IL-1RA in the uvea and retina during endotoxin-induced uveitis in the rat, Invest Ophthalmol Vis Sci, vol.35, pp.3873-3883, 1994.

Y. Guex-crosier, A. Wittwer, and F. Roberge, Intraocular production of a cytokine (CINC) responsible for neutrophil infiltration in endotoxin induced uveitis., British Journal of Ophthalmology, vol.80, issue.7, pp.649-653, 1996.
DOI : 10.1136/bjo.80.7.649

O. Goureau, D. Hicks, Y. Courtois, and Y. De-kozak, Induction and Regulation of Nitric Oxide Synthase in Retinal M??ller Glial Cells, Journal of Neurochemistry, vol.63, issue.1, pp.310-317, 1994.
DOI : 10.1046/j.1471-4159.1994.63010310.x

O. Goureau, J. Bellot, B. Thillaye, Y. Courtois, and Y. De-kozak, Increased nitric oxide production in endotoxin-induced uveitis. Reduction of uveitis by an inhibitor of nitric oxide synthase, J Immunol, vol.154, pp.6518-6523, 1995.

P. Yang, J. Smith, K. Damodar, S. Planck, and J. Rosenbaum, Visualization of Cell Death In Vivo during Murine Endotoxin-Induced Uveitis, Investigative Opthalmology & Visual Science, vol.44, issue.5, pp.1993-1997, 2003.
DOI : 10.1167/iovs.02-0582

T. Hirai and K. Chida, Protein Kinase Czeta (PKCzeta): Activation Mechanisms and Cellular Functions, Journal of Biochemistry, vol.133, issue.1, pp.1-7, 2003.
DOI : 10.1093/jb/mvg017

URL : http://jb.oxfordjournals.org/cgi/content/short/133/1/1

P. Crisanti, L. A. Lim, D. Omri, and B. , Aspirin prevention of NMDA-induced neuronal death by direct protein kinase C?? inhibition, Journal of Neurochemistry, vol.22, issue.6, pp.1587-1593, 2005.
DOI : 10.1111/j.1471-4159.2005.03157.x

S. Manna and B. Aggarwal, IL-13 suppresses TNF-induced activation of nuclear factor-B, activation protein-1, and apoptosis, J Immunol, vol.161, pp.2863-2872, 1998.

E. Kopp and R. Medzhitov, The Toll-receptor family and control of innate immunity, Current Opinion in Immunology, vol.11, issue.1, pp.13-21, 1999.
DOI : 10.1016/S0952-7915(99)80003-X

S. Wright, R. Ramos, P. Tobias, R. Ulevitch, and J. Mathison, CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein, Science, vol.249, issue.4975, pp.1431-1433, 1990.
DOI : 10.1126/science.1698311

K. Miyake, Innate recognition of lipopolysaccharide by Toll-like receptor 4???MD-2, Trends in Microbiology, vol.12, issue.4, pp.186-192, 2004.
DOI : 10.1016/j.tim.2004.02.009

S. Shishodia and B. Aggarwal, Nuclear factor-??B: a friend or a foe in cancer?, Biochemical Pharmacology, vol.68, issue.6, pp.1071-1080, 2004.
DOI : 10.1016/j.bcp.2004.04.026

X. Li and G. Stark, NF??B-dependent signaling pathways, Experimental Hematology, vol.30, issue.4, pp.285-296, 2002.
DOI : 10.1016/S0301-472X(02)00777-4

G. Bonizzi and K. M. , The two NF-??B activation pathways and their role in innate and adaptive immunity, Trends in Immunology, vol.25, issue.6, pp.280-288, 2004.
DOI : 10.1016/j.it.2004.03.008

M. Karin and A. Lin, NF-??B at the crossroads of life and death, Nature Immunology, vol.3, issue.3, pp.221-227, 2002.
DOI : 10.1038/ni0302-221

T. Collins, M. Read, A. Neish, M. Whitley, D. Thanos et al., Transcriptional regulation of endothelial cell adhesion molecules: nF-B and cytokine-inducible enhancers, FASEB J, vol.9, pp.899-909, 1995.

T. Lawrence, D. Gilroy, P. Colville-nash, and D. Willoughby, Possible new role for NF-B in the resolution of inflammation, Nature Medicine, vol.7, issue.12, pp.1291-1297, 2001.
DOI : 10.1038/nm1201-1291

S. Kastenbauer and H. W. Ziegler-heitbrock, NF-kB1 (p50) is upregulated in lipopolysaccharide tolerance and can block tumor necrosis factor gene expression, Infect Immun, vol.67, pp.1553-1559, 1999.

J. Wessells, M. Baer, H. Young, C. E. Brown, K. Siebenlist et al., BCL-3 and NF-??B p50 Attenuate Lipopolysaccharide-induced Inflammatory Responses in Macrophages, Journal of Biological Chemistry, vol.279, issue.48, pp.49995-50003, 2004.
DOI : 10.1074/jbc.M404246200

D. Gilroy, T. Lawrence, M. Perretti, and A. Rossi, Inflammatory Resolution: new opportunities for drug discovery, Nature Reviews Drug Discovery, vol.92, issue.5, pp.401-416, 2004.
DOI : 10.1172/JCI200318012

P. Crisanti, O. Laplace, E. Lecain, L. Jonet, J. Jeanny et al., The role of PKC?? in NMDA-induced retinal ganglion cell death: Prevention by aspirin, Apoptosis, vol.95, issue.6, pp.983-991, 2006.
DOI : 10.1007/s10495-006-6750-2

A. Duran, M. Diaz-meco, and J. Moscat, Essential role of RelA Ser311 phosphorylation by ??PKC in NF-??B transcriptional activation, The EMBO Journal, vol.22, issue.15, pp.3910-3918, 2003.
DOI : 10.1093/emboj/cdg370

S. Savkovic, A. Koutsouris, and G. Hecht, PKC?? participates in activation of inflammatory response induced by enteropathogenic E. coli, AJP: Cell Physiology, vol.285, issue.3, pp.512-521, 2003.
DOI : 10.1152/ajpcell.00444.2002

M. Diaz-meco, E. Berra, M. Municio, L. Sanz, J. Lozano et al., A dominant negative protein kinase C zeta subspecies blocks NF-kappa B activation., Molecular and Cellular Biology, vol.13, issue.8, pp.4770-4775, 1993.
DOI : 10.1128/MCB.13.8.4770

J. Moscat and M. Diaz-meco, The atypical protein kinase Cs, EMBO reports, vol.20, issue.5, pp.399-403, 2000.
DOI : 10.1093/embo-reports/kvd098

M. Leitges, L. Sanz, P. Martin, A. Duran, U. Braun et al., Targeted Disruption of the ??PKC Gene Results in the Impairment of the NF-??B Pathway, Molecular Cell, vol.8, issue.4, pp.771-780, 2001.
DOI : 10.1016/S1097-2765(01)00361-6

M. Gadjeva, M. Tomczak, M. Zhang, Y. Wang, K. Dull et al., A Role for NF-??B Subunits p50 and p65 in the Inhibition of Lipopolysaccharide-Induced Shock, The Journal of Immunology, vol.173, issue.9, pp.5786-5793, 2004.
DOI : 10.4049/jimmunol.173.9.5786

H. Kuwata, Y. Watanabe, H. Miyoshi, M. Yamamoto, T. Kaisho et al., IL-10-inducible Bcl-3 negatively regulates LPS-induced TNF-?? production in macrophages, Blood, vol.102, issue.12, pp.4123-4129, 2003.
DOI : 10.1182/blood-2003-04-1228

M. Schnare, G. Barton, A. Holt, K. Takeda, S. Akira et al., Toll-like receptors control activation of adaptive immune responses, Nature Immunology, vol.20, issue.10, pp.947-950, 2001.
DOI : 10.1038/ni712

B. Brito, D. Zamora, R. Bonnah, Y. Pan, S. Planck et al., Toll-like receptor 4 and CD14 expression in human ciliary body and TLR-4 in human iris endothelial cells, Experimental Eye Research, vol.79, issue.2, pp.203-208, 2004.
DOI : 10.1016/j.exer.2004.03.012

J. Chang, P. Mccluskey, and D. Wakefield, Expression of Toll-like Receptor 4 and Its Associated Lipopolysaccharide Receptor Complex by Resident Antigen-Presenting Cells in the Human Uvea, Investigative Opthalmology & Visual Science, vol.45, issue.6, pp.1871-1878, 2004.
DOI : 10.1167/iovs.03-1113

O. Marie, B. Thillaye-goldenberg, M. Naud, and Y. De-kozak, Inhibition of endotoxin-induced uveitis and potentiation of local TNF-and inter- leukin-6 mRNA expression by interleukin-13, Invest Ophthalmol Vis Sci, vol.40, pp.2275-2282, 1999.

C. Lemaitre, B. Thillaye-goldenberg, M. Naud, and Y. De-kozak, The effects of intraocular injection of interleukin-13 on endotoxin-induced uveitis in rats, Invest Ophthalmol Vis Sci, vol.42, pp.2022-2030, 2001.

A. Minty, P. Chalon, J. Derocq, X. Dumont, J. Guillemot et al., lnterleukin-13 is a new human lymphokine regulating inflammatory and immune responses, Nature, vol.362, issue.6417, pp.248-250, 1993.
DOI : 10.1038/362248a0

J. Cuschieri, K. Umanskiy, and J. Solomkin, PKC-?? is essential for endotoxin-induced macrophage activation1,2, Journal of Surgical Research, vol.121, issue.1, pp.76-83, 2004.
DOI : 10.1016/j.jss.2004.04.005

I. Pouvreau, J. Zech, B. Thillaye-goldenberg, M. Naud, N. Van-rooijen et al., Effect of macrophage depletion by liposomes containing dichloromethylene-diphosphonate on endotoxin-induced uveitis, Journal of Neuroimmunology, vol.86, issue.2, pp.171-181, 1998.
DOI : 10.1016/S0165-5728(98)00042-3

S. Hoey, P. Grabowski, S. Ralston, J. Forrester, and J. Liversidge, Nitric oxide accelerates the onset and increases the severity of experimental autoimmune uveoretinitis through an IFN--dependent mechanism, J Immunol, vol.159, pp.5132-5142, 1997.

C. Anderson and D. Mosser, A novel phenotype for an activated macrophage: the type 2 activated macrophage, J Leukoc Biol, vol.72, pp.101-106, 2002.

B. Thillaye-goldenberg, O. Goureau, M. Naud, and Y. De-kozak, Delayed onset and decreased severity of experimental autoimmune uveoretinitis in mice lacking nitric oxide synthase type 2, Journal of Neuroimmunology, vol.110, issue.1-2, pp.31-44, 2000.
DOI : 10.1016/S0165-5728(00)00313-1

L. Erwig, D. Kluth, G. Walsh, and A. Rees, Initial cytokine exposure determines function of macrophages and renders them unresponsive to other cytokines, J Immunol, vol.161, pp.1983-1988, 1998.

M. Robertson, L. Erwig, J. Liversidge, J. Forrester, A. Rees et al., Retinal microenvironment controls resident and infiltrating macrophage function during uveoretinitis, Invest Ophthalmol Vis Sci, vol.43, pp.2250-2257, 2002.

B. Omri, C. Blancher, N. B. Marty, M. Rutin, J. Molina et al., Retinal dysplasia in mice lacking p56lck, Oncogene, vol.16, issue.18, pp.2351-2356, 1998.
DOI : 10.1038/sj.onc.1201761

M. Magone and S. Whitcup, Mechanisms of Intraocular Inflammation, Chem Immunol, vol.73, pp.90-119, 1999.
DOI : 10.1159/000058742

R. Tapping and P. Tobias, Soluble CD14-Mediated Cellular Responses to Lipopolysaccharide, Chem Immunol, vol.74, pp.108-121, 2000.
DOI : 10.1159/000058751

H. Xu, R. Dawson, I. Crane, and J. Liversidge, Leukocyte Diapedesis In Vivo Induces Transient Loss of Tight Junction Protein at the Blood???Retina Barrier, Investigative Opthalmology & Visual Science, vol.46, issue.7, pp.2487-2494, 2005.
DOI : 10.1167/iovs.04-1333

U. Chakravarthy, A. Stitt, J. Mcnally, J. Bailie, E. Hoey et al., Nitric oxide synthase activity and expression in retinal capillary endothelial cells and pericytes, Current Eye Research, vol.17, issue.4, pp.285-294, 1995.
DOI : 10.3109/02713689509033528

J. De-boer, J. Limpens, S. Orengo-nania, P. De-jong, L. Heij et al., Low mature TGF-2 levels in aqueous humor during uveitis, Invest Ophthalmol Vis Sci, vol.35, pp.3702-3710, 1994.

C. Nathan, Neutrophils and immunity: challenges and opportunities, Nature Reviews Immunology, vol.280, issue.3, pp.173-182, 2006.
DOI : 10.1183/09031936.96.09071482

J. Liversidge, A. Dick, and S. Gordon, Nitric Oxide Mediates Apoptosis Through Formation of Peroxynitrite and Fas/Fas-Ligand Interactions in Experimental Autoimmune Uveitis, The American Journal of Pathology, vol.160, issue.3, pp.905-916, 2002.
DOI : 10.1016/S0002-9440(10)64913-9

M. Karin, Mitogen-Activated Protein Kinase Cascades as Regulators of Stress Responses, Annals of the New York Academy of Sciences, vol.11, issue.2, pp.139-146, 1998.
DOI : 10.1016/S0092-8674(00)80162-2

Q. Li and I. Verma, NF-??B regulation in the immune system, Nature Reviews Immunology, vol.2, issue.10, pp.725-734, 2002.
DOI : 10.1038/nri910

K. Ohta, K. Nakayama, T. Kurokawa, T. Kikuchi, and N. Yoshimura, Inhibitory effects of pyrrolidine dithiocarbamate on endotoxin-induced uveitis in Lewis rats, Invest Ophthalmol Vis Sci, vol.43, pp.744-750, 2002.

Y. Suzuki, K. Ohgami, K. Shiratori, X. Jin, I. Ilieva et al., Suppressive effects of astaxanthin against rat endotoxin-induced uveitis by inhibiting the NF-??B signaling pathway, Experimental Eye Research, vol.82, issue.2, pp.275-281, 2006.
DOI : 10.1016/j.exer.2005.06.023

A. Brasier, M. Lu, T. Hai, Y. Lu, and I. Boldogh, NF-kappa B-inducible BCL-3 Expression Is an Autoregulatory Loop Controlling Nuclear p50/NF-kappa B1 Residence, Journal of Biological Chemistry, vol.276, issue.34, pp.32080-32093, 2001.
DOI : 10.1074/jbc.M102949200

A. Dick, J. Forrester, J. Liversidge, and A. Cope, The role of tumour necrosis factor (TNF-??) in experimental autoimmune uveoretinitis (EAU), Progress in Retinal and Eye Research, vol.23, issue.6, pp.617-637, 2004.
DOI : 10.1016/j.preteyeres.2004.06.005

R. Tilton, K. Chang, J. Corbett, T. Misko, M. Currie et al., Endotoxin-induced uveitis in the rat is attenuated by inhibition of nitric oxide production, Invest Ophthalmol Vis Sci, vol.35, pp.3278-3288, 1994.

R. Stuart and S. Nigam, Regulated assembly of tight junctions by protein kinase C., Proceedings of the National Academy of Sciences, vol.92, issue.13, pp.6072-6076, 1995.
DOI : 10.1073/pnas.92.13.6072

V. Dodane and B. Kachar, Identification of Isoforms of G Proteins and PKC that Colocalize with Tight Junctions, Journal of Membrane Biology, vol.149, issue.3, pp.199-209, 1996.
DOI : 10.1007/s002329900020

P. Bhattacherjee, R. Williams, and K. Eakins, An evaluation of ocular inflammation following the injection of bacterial endotoxin into the rat foot pad, Invest Ophthalmol Vis Sci, vol.24, pp.196-202, 1983.

D. Parks, M. Cheung, C. Chan, and F. Roberge, The Role of Nitric Oxide in Uveitis, Archives of Ophthalmology, vol.112, issue.4, pp.544-546, 1994.
DOI : 10.1001/archopht.1994.01090160124032

A. De-vos, M. Van-haren, C. Verhagen, R. Hoekzema, and A. Kijlstra, Kinetics of intraocular tumor necrosis factor and interleukin-6 in endotoxin-induced uveitis in the rat, Invest Ophthalmol Vis Sci, vol.35, pp.1100-1106, 1994.

K. Javaid, A. Rahman, K. Anwar, R. Frey, R. Minshall et al., Tumor Necrosis Factor-alpha Induces Early-Onset Endothelial Adhesivity by Protein Kinase Czeta-Dependent Activation of Intercellular Adhesion Molecule-1, Circulation Research, vol.92, issue.10, pp.1089-1097, 2003.
DOI : 10.1161/01.RES.0000072971.88704.CB

Q. Li, B. Sun, D. Matteson, O. Brien, T. Chan et al., Cytokines and Apoptotic Molecules in Experimental Melanin-Protein Induced Uveitis (EMIU) and Experimental Autoimmune Uveoretinitis (EAU), Autoimmunity, vol.159, issue.3, pp.171-182, 1999.
DOI : 10.1016/0167-5699(92)90037-8

K. Koizumi, V. Poulaki, S. Doehmen, G. Welsandt, S. Radetzky et al., Contribution of TNF-?? to Leukocyte Adhesion, Vascular Leakage, and Apoptotic Cell Death in Endotoxin-Induced Uveitis In Vivo, Investigative Opthalmology & Visual Science, vol.44, issue.5, pp.2184-2191, 2003.
DOI : 10.1167/iovs.02-0589

J. Smith, P. Hart, S. Standfield, D. Coster, S. Wing et al., Apoptosis is a prominent feature of acute anterior uveitis in the Fischer 344 rat, British Journal of Ophthalmology, vol.84, issue.2, pp.205-211, 2000.
DOI : 10.1136/bjo.84.2.205

F. Behar-cohen, M. Savoldelli, J. Parel, O. Goureau, B. Thillaye-goldenberg et al., Reduction of corneal edema in endotoxin-induced uveitis after application of L-NAME as nitric oxide synthase inhibitor in rats by iontophoresis, Invest Ophthalmol Vis Sci, vol.39, pp.897-904, 1998.

C. Power, J. Wang, B. Manning, M. Kell, N. Aherne et al., Bacterial Lipoprotein Delays Apoptosis in Human Neutrophils through Inhibition of Caspase-3 Activity: Regulatory Roles for CD14 and TLR-2, The Journal of Immunology, vol.173, issue.8, pp.5229-5237, 2004.
DOI : 10.4049/jimmunol.173.8.5229

C. Cuello, D. Wakefield, D. Girolamo, and N. , Neutrophil accumulation correlates with type IV collagenase/gelatinase activity in endotoxin induced uveitis, British Journal of Ophthalmology, vol.86, issue.3, pp.290-295, 2002.
DOI : 10.1136/bjo.86.3.290

C. Scotton, F. Martinez, M. Smelt, M. Sironi, M. Locati et al., Transcriptional Profiling Reveals Complex Regulation of the Monocyte IL-1?? System by IL-13, The Journal of Immunology, vol.174, issue.2, pp.834-845, 2005.
DOI : 10.4049/jimmunol.174.2.834

K. Theilgaard-mö-nch, S. Knudsen, P. Follin, and N. Borregaard, The Transcriptional Activation Program of Human Neutrophils in Skin Lesions Supports Their Important Role in Wound Healing, The Journal of Immunology, vol.172, issue.12, pp.7684-7693, 2004.
DOI : 10.4049/jimmunol.172.12.7684