Skip to Main content Skip to Navigation
Journal articles

Reconstitution of human airway tissue in the humanized xenograft model.

Abstract : Normal human airway epithelial tissue may be reconstituted in the humanized xenograft model in immunodeficient NUDE mice. Epithelial cells dissociated from human fetal or adult tissue are seeded on a denuded rat trachea and implanted in the NUDE mice. After a first step of dedifferentiation, the human epithelial cells adhere on the denuded basal lamina of the rat host trachea and progressively reconstitute a normal well-differentiated epithelium after several steps of migration, proliferation, stratification and redifferentiation.
Complete list of metadatas

https://www.hal.inserm.fr/inserm-00146033
Contributor : Philippe Birembaut <>
Submitted on : Monday, May 14, 2007 - 10:07:53 AM
Last modification on : Wednesday, August 30, 2017 - 1:13:32 AM

Links full text

Identifiers

Collections

Citation

Sandie Escotte, Corinne Catusse, Christelle Coraux, Edith Puchelle. Reconstitution of human airway tissue in the humanized xenograft model.. Journal of Cystic Fibrosis, Elsevier, 2004, 3 Suppl 2, pp.63-5. ⟨10.1016/j.jcf.2004.05.014⟩. ⟨inserm-00146033⟩

Share

Metrics

Record views

268