S. Maroux, D. Louvard, and J. Barrati, The aminopeptidase from hog intestinal brush border, Biochimica et Biophysica Acta (BBA) - Enzymology, vol.321, issue.1, pp.282-295, 1973.
DOI : 10.1016/0005-2744(73)90083-1

A. Look, R. Ashmun, L. Shapiro, and S. Peiper, Human myeloid plasma membrane glycoprotein CD13 (gp150) is identical to aminopeptidase N., Journal of Clinical Investigation, vol.83, issue.4, pp.1299-1307, 1989.
DOI : 10.1172/JCI114015

C. L. Yeager, R. A. Ashmun, R. K. Williams, C. B. Cardellichio, L. H. Shapiro et al., Human aminopeptidase N is a receptor for human coronavirus 229E, Nature, vol.357, issue.6377, pp.420-422, 1992.
DOI : 10.1038/357420a0

G. Waksman, R. Bouboutou, J. Devin, S. Bourgoin, F. Cesselin et al., In vitro and in vivo effects of kelatorphan on enkephalin metabolism in rodent brain, European Journal of Pharmacology, vol.117, issue.2, pp.233-243, 1985.
DOI : 10.1016/0014-2999(85)90608-9

S. Zini, M. C. Fournié-zaluski, E. Chauvel, B. P. Roques, P. Corvol et al., Identification of metabolic pathways of brain angiotensin II and III using specific aminopeptidase inhibitors: predominant role of angiotensin III in the control of vasopressin release., Proceedings of the National Academy of Sciences, vol.93, issue.21, pp.11968-11973, 1996.
DOI : 10.1073/pnas.93.21.11968

J. Olsen, G. M. Cowell, E. Konigshofer, E. M. Danielsen, J. Moller et al., Complete amino acid sequence of human intestinal aminopeptidase N as deduced from cloned cDNA, FEBS Letters, vol.16, issue.2, pp.307-314, 1988.
DOI : 10.1016/0014-5793(88)80502-7

B. Malfroy, H. Kado-fong, C. Gros, B. Giros, J. C. Schwartz et al., Molecular cloning and amino acid sequence of rat kidney aminopeptidase M: A member of a super family of zinc-metallohydrolases, Biochemical and Biophysical Research Communications, vol.161, issue.1, pp.236-241, 1989.
DOI : 10.1016/0006-291X(89)91586-6

X. F. Yang, P. E. Milhiet, F. Gaudoux, P. Crine, and G. Boileau, hybridization, Biochemistry and Cell Biology, vol.71, issue.5-6, pp.278-287, 1993.
DOI : 10.1139/o93-042

N. D. Rawlings and A. J. Barret, [13] Evolutionary families of metallopeptidases, Methods Enzymol, vol.248, pp.183-228, 1995.
DOI : 10.1016/0076-6879(95)48015-3

K. M. Fukasawa, K. Fukasawa, M. Kanai, S. Fugii, and M. Harada, Molecular Cloning and Expression of Rat Liver Aminopeptidase B, Journal of Biological Chemistry, vol.271, issue.48, pp.30731-30735, 1996.
DOI : 10.1074/jbc.271.48.30731

S. Cadel, T. Foulon, A. Viron, A. Balogh, S. Midol-monnet et al., Aminopeptidase B from the rat testis is a bifunctional enzyme structurally related to leukotriene-A4 hydrolase, Proceedings of the National Academy of Sciences, vol.136, issue.9, pp.2963-2968, 1997.
DOI : 10.1210/en.136.9.4133

C. D. Funk, O. Radmark, J. Y. Fu, T. Matsumoto, H. Jornvall et al., Molecular cloning and amino acid sequence of leukotriene A4 hydrolase., Proceedings of the National Academy of Sciences, vol.84, issue.19, pp.6677-6681, 1987.
DOI : 10.1073/pnas.84.19.6677

D. B. Constam, A. R. Tobler, A. Rensing-ehl, I. Kemler, L. B. Hersh et al., Puromycin-sensitive Aminopeptidase: SEQUENCE ANALYSIS, EXPRESSION, AND FUNCTIONAL CHARACTERIZATION, Journal of Biological Chemistry, vol.270, issue.45, pp.26931-26939, 1995.
DOI : 10.1074/jbc.270.45.26931

B. Schauder, L. Schomburg, J. Kohrle, and K. Bauer, Cloning of a cDNA encoding an ectoenzyme that degrades thyrotropin-releasing hormone., Proceedings of the National Academy of Sciences, vol.91, issue.20, pp.9534-9538, 1994.
DOI : 10.1073/pnas.91.20.9534

S. R. Keller, H. M. Scott, C. C. Mastick, R. Aebersold, and G. E. Lienhard, Cloning and Characterization of a Novel Insulin-regulated Membrane Aminopeptidase from Glut4 Vesicles, Journal of Biological Chemistry, vol.270, issue.40, pp.23612-23618, 1995.
DOI : 10.1074/jbc.270.40.23612

M. T. Mccaman and J. D. Gabe, Sequence of the promoter and 5? coding region of pepN, and the amino-terminus of peptidase N from Escherichia coli K-12, MGG Molecular & General Genetics, vol.143, issue.1, pp.148-152, 1986.
DOI : 10.1007/BF00330202

J. Wang, C. , and M. , Histidine residue in the zinc-binding motif of aminopeptidase A is critical for enzymatic activity., Proceedings of the National Academy of Sciences, vol.90, issue.4, pp.1222-1226, 1993.
DOI : 10.1073/pnas.90.4.1222

G. Vazeux, J. Wang, P. Corvol, and C. Llorens-cortès, Identification of Glutamate Residues Essential for Catalytic Activity and Zinc Coordination in Aminopeptidase A, Journal of Biological Chemistry, vol.271, issue.15, pp.9069-9074, 1996.
DOI : 10.1074/jbc.271.15.9069

J. F. Medina, A. Wetterholm, O. Radmark, R. Shapiro, J. Haeggström et al., Leukotriene A4 hydrolase: determination of the three zinc-binding ligands by site-directed mutagenesis and zinc analysis., Proceedings of the National Academy of Sciences, vol.88, issue.17, pp.7620-7624, 1991.
DOI : 10.1073/pnas.88.17.7620

A. Wetterholm, J. F. Medina, O. Radmark, R. Shapiro, J. Haeggström et al., Leukotriene A4 hydrolase: abrogation of the peptidase activity by mutation of glutamic acid-296., Proceedings of the National Academy of Sciences, vol.89, issue.19, pp.9141-9145, 1992.
DOI : 10.1073/pnas.89.19.9141

B. W. Matthews, Structural basis of the action of thermolysin and related zinc peptidases, Accounts of Chemical Research, vol.21, issue.9, pp.333-340, 1988.
DOI : 10.1021/ar00153a003

C. V. Jongeneel, J. Bouvier, and A. Bairoch, A unique signature identifies a family of zinc-dependent metallopeptidases, FEBS Letters, vol.13, issue.2, pp.211-214, 1989.
DOI : 10.1016/0014-5793(89)80471-5

H. Toh, M. Minami, and T. Shimizu, Molecular evolution and zinc ion binding motif of leukotriene A4 hydrolase, Biochemical and Biophysical Research Communications, vol.171, issue.1, pp.216-221, 1990.
DOI : 10.1016/0006-291X(90)91379-7

A. Helene, A. Beaumont, R. , and B. P. , Functional residues at the active site of aminopeptidase N, European Journal of Biochemistry, vol.263, issue.2, pp.385-393, 1991.
DOI : 10.1016/0076-6879(77)47043-5

J. Xie, J. M. Soleilhac, C. Schmidt, J. Peyroux, B. P. Roques et al., New kelatorphan-related inhibitors of enkephalin metabolism: improved antinociceptive properties, Journal of Medicinal Chemistry, vol.32, issue.7, pp.1497-1503, 1989.
DOI : 10.1021/jm00127a017

M. Digregorio, D. S. Pickering, C. , and W. W. , Multiple sites and synergism in the binding of inhibitors to microsomal aminopeptidase, Biochemistry, vol.27, issue.10, pp.3613-3617, 1988.
DOI : 10.1021/bi00410a013

S. K. Burley, P. R. David, R. M. Sweet, A. Taylor, and W. N. Lipscomb, Structure determination and refinement of bovine lens leucine aminopeptidase and its complex with bestatin, Journal of Molecular Biology, vol.224, issue.1, pp.113-140, 1992.
DOI : 10.1016/0022-2836(92)90580-D

H. Kim and W. N. Lipscomb, X-ray crystallographic determination of the structure of bovine lens leucine aminopeptidase complexed with amastatin: Formulation of a catalytic mechanism featuring a gem-diolate transition state, Biochemistry, vol.32, issue.33, pp.8465-8478, 1993.
DOI : 10.1021/bi00084a011

B. P. Roques, E. Lucas-soroca, P. Chaillet, J. Costentin, and M. C. Fournié-zaluski, Complete differentiation between enkephalinase and angiotensin-converting enzyme inhibition by retro-thiorphan., Proceedings of the National Academy of Sciences, vol.80, issue.11, pp.3178-3182, 1983.
DOI : 10.1073/pnas.80.11.3178

M. C. Fournié-zaluski, P. Coric, S. Turcaud, L. Bruetschy, E. Lucas et al., Potent and systemically active aminopeptidase N inhibitors designed from active-site investigation, Journal of Medicinal Chemistry, vol.35, issue.7, pp.1259-1266, 1992.
DOI : 10.1021/jm00085a013

C. Schmidt, J. Peyroux, F. Noble, M. C. Fournié-zaluski, R. et al., Analgesic responses elecited by endogenous enkephalins (protected by mixed peptidase inhibitors) in a variety of morphine-sensitive noxious tests, European Journal of Pharmacology, vol.192, issue.2, pp.253-262, 1991.
DOI : 10.1016/0014-2999(91)90050-Z

U. K. Laemmli, Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4, Nature, vol.244, issue.5259, pp.680-685, 1970.
DOI : 10.1038/227680a0

Z. Vogel and M. And-altstein, The adsorption of enkephalin to porous polystyrene beads: A simple assay for enkephalin hydrolysis, FEBS Letters, vol.53, issue.2, pp.332-335, 1977.
DOI : 10.1016/0014-5793(77)80469-9

Y. Xu, D. Wellner, and D. A. Scheinberg, Substance P and Bradykinin Are Natural Inhibitors of CD13/Aminopeptidase N, Biochemical and Biophysical Research Communications, vol.208, issue.2, pp.664-674, 1995.
DOI : 10.1006/bbrc.1995.1390

M. C. Fournié-zaluski, A. Coulaud, R. Bouboutou, P. Chaillet, J. Devin et al., New bidentates as full inhibitors of enkephalin-degrading enzymes: synthesis and analgesic properties, Journal of Medicinal Chemistry, vol.28, issue.9, pp.1158-1169, 1985.
DOI : 10.1021/jm00147a007

B. Chevrier, H. Orchymont, C. Schalk, C. Tarnus, and D. Moras, The Structure of the Aeromonas proteolytica Aminopeptidase Complexed with a Hydroxamate Inhibitor. Involvement in Catalysis of Glu151 and Two Zinc Ions of the Co-Catalytic Unit, European Journal of Biochemistry, vol.258, issue.2, pp.393-398, 1996.
DOI : 10.1039/cs9942300083

B. P. Roques, Zinc metallopeptidases: Active site structure and design of selective and mixed inhibitors: New approaches in the search for analgesics and anti-hypertensives, Biochemical Society Transactions, vol.21, issue.3, pp.678-685, 1993.
DOI : 10.1042/bst0210678

H. Kim, S. K. Burley, and W. N. Lipscomb, Re-refinement of the X-ray Crystal Structure of Bovine Lens Leucine Aminopeptidase Complexed with Bestatin, Journal of Molecular Biology, vol.230, issue.3, pp.722-724, 1993.
DOI : 10.1006/jmbi.1993.1193