Two-Photon Water-Soluble Dyes and Their Amine-Reactive Derivatives for Two-Photon Bio-Imaging Applications - Inserm - Institut national de la santé et de la recherche médicale Accéder directement au contenu
Article Dans Une Revue Nonlinear optics, quantum optics Année : 2006

Two-Photon Water-Soluble Dyes and Their Amine-Reactive Derivatives for Two-Photon Bio-Imaging Applications

Résumé

Two series of water-soluble blue fluorescent two-photon excited chromophores for bio-imaging based on bis-stilbenic structure were synthesized. Wadsworth-Emmons reaction was used to build one dimensional D-π-aromatic core-π-D structures. The water solubility is induced by three oligo-ethylene glycol moieties in positions 3, 4, and 5 of the peripheral phenyl ring. Their two-photon absorption (TPA) cross-section in the range of 150 GM at 700 nm have been measured by the way of their two-photon excited fluorescence (TPEF) properties. It is 10 to 100 times higher than commercial dyes commonly used in bio-imaging. This makes these new TPA chromophores good candidates for in-vivo two-photon excited (TPE) microscopy.
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Dates et versions

inserm-00144707 , version 1 (04-05-2007)

Identifiants

  • HAL Id : inserm-00144707 , version 1

Citer

Ali Hayek, Frédéric Bolze, Jean-François Nicoud, Alain Duperray, Alexei Grichine, et al.. Two-Photon Water-Soluble Dyes and Their Amine-Reactive Derivatives for Two-Photon Bio-Imaging Applications. Nonlinear optics, quantum optics , 2006, 35 (1-3), pp.155-164. ⟨inserm-00144707⟩
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