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Microstructuration of protein matrices by laser-induced photochemistry

Abstract : We report on the laser fabrication of BSA and type I collagen microstructures using Eosin Y or Rose Bengal photo sensitizers. Similar cross-linking results have been obtained by one-photon absorption or two-photon absorption using a green Q-switched microlaser or a near-infrared mode-locked Ti:sapphire laser, respectively. The microstructure resolution depends on the laser power, but is typically limited by the size of the laser beam within the sample. The cross-linking of type I collagen with Rose Bengal is obtained in acidic conditions with a large photosensitizer concentration in the millimole range. The biocompatibility of microstructures was demonstrated by observing the specific adhesion of cells on collagen lines.
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Submitted on : Tuesday, May 11, 2010 - 2:04:55 PM
Last modification on : Thursday, December 12, 2019 - 9:48:05 AM
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  • HAL Id : inserm-00144702, version 1



Monica Iosin, Olivier Stephan, Simion Astilean, Alain Duperray, Patrice L. Baldeck. Microstructuration of protein matrices by laser-induced photochemistry. Journal of Optoelectronics and Advanced Materials, 2007, 9 (3), pp.716-720. ⟨inserm-00144702⟩



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