Skip to Main content Skip to Navigation
Journal articles

Overexpression of cellular prion protein induces an antioxidant environment altering T cell development in the thymus.

Abstract : Cellular prion protein (PrP(C)) is an ubiquitously expressed glycoprotein whose roles are still widely discussed, particularly in the field of immunology. Using TgA20- and Tg33-transgenic mice overexpressing PrP(C), we investigated the consequences of this overexpression on T cell development. In both models, overexpression of PrP(C) induces strong alterations at different steps of T cell maturation. On TgA20 mice, we observed that these alterations are cell autonomous and lead to a decrease of alphabeta T cells and a concomitant increase of gammadelta T cell numbers. PrP(C) has been shown to bind and chelate copper and, interestingly, under a copper supplementation diet, TgA20 mice presented a partial restoration of the alphabeta T cell development, suggesting that PrP(C) overexpression, by chelating copper, generates an antioxidant context differentially impacting on alphabeta and gammadelta T cell lineage.
Document type :
Journal articles
Complete list of metadatas

Cited literature [52 references]  Display  Hide  Download

https://www.hal.inserm.fr/inserm-00144344
Contributor : Patrice Marche <>
Submitted on : Wednesday, May 2, 2007 - 7:36:21 PM
Last modification on : Wednesday, January 29, 2020 - 11:10:03 AM
Long-term archiving on: : Friday, November 25, 2016 - 4:28:13 PM

File

 Restricted access
To satisfy the distribution rights of the publisher, the document is embargoed until : jamais

Please log in to resquest access to the document

Identifiers

  • HAL Id : inserm-00144344, version 1
  • PUBMED : 16517717

Collections

Citation

Evelyne Jouvin-Marche, Valérie Attuil-Audenis, Catherine Aude-Garcia, Walid Rachidi, Mark Zabel, et al.. Overexpression of cellular prion protein induces an antioxidant environment altering T cell development in the thymus.. Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2006, 176 (6), pp.3490-7. ⟨inserm-00144344⟩

Share

Metrics

Record views

642