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Expression of estrogen receptor beta in prostate carcinoma cells inhibits invasion and proliferation and triggers apoptosis.

Abstract : The involvement of estrogen receptor beta (ERbeta) in prostate carcinogenesis has been hypothesized. Several reports have shown that ERbeta expression was decreased when prostate cells undergo neoplastic transformation, suggesting that it could play a tumor-suppressor role. By restoring ERbeta expression in prostatic carcinoma cells by adenoviral delivery, we aimed to test this hypothesis. We observed that ERbeta strongly inhibited the invasiveness and the growth of these cells. In addition, ERbeta cells were undergoing apoptosis, as shown by quantification of Bax, poly(ADP-ribose) polymerase and caspase-3 expression. Our data suggest that ERbeta acts as a tumor-suppressor by its anti-proliferative, anti-invasive and pro-apoptotic properties.
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https://www.hal.inserm.fr/inserm-00143968
Contributor : Gwendal Lazennec <>
Submitted on : Monday, April 30, 2007 - 2:53:22 PM
Last modification on : Wednesday, July 25, 2018 - 10:52:02 AM
Long-term archiving on: : Wednesday, April 7, 2010 - 12:34:04 AM

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Jennifer Cheng, Eun Jig Lee, Laird Madison, Gwendal Lazennec. Expression of estrogen receptor beta in prostate carcinoma cells inhibits invasion and proliferation and triggers apoptosis.. FEBS Letters, Wiley, 2004, 566 (1-3), pp.169-72. ⟨10.1016/j.febslet.2004.04.025⟩. ⟨inserm-00143968⟩

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