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IL-8 expression and its possible relationship with estrogen-receptor-negative status of breast cancer cells.

Abstract : Estrogen-receptor (ER) status is an important parameter in breast cancer management as ER-positive breast cancers have a better prognosis than ER-negative tumors. This difference comes essentially from the lower aggressiveness and invasiveness of ER-positive tumors. Here, we demonstrate, that interleukin-8 (IL-8) was clearly overexpressed in most ER-negative breast, ovary cell lines and breast tumor samples tested, whereas no significant IL-8 level could be detected in ER-positive breast or ovarian cell lines. We have also cloned human IL-8 from ER-negative MDA-MB-231 cells, and we show that IL-8 produced by breast cancer cells is identical to monocyte-derived IL-8. Interestingly, the invasion potential of ER-negative breast cancer cells is associated at least in part with expression of IL-8, but not with IL-8 receptor levels. Moreover, IL-8 increases the invasiveness of ER-positive breast cancer cells by two fold, thus confirming the invasion-promoting role of IL-8. On the other hand, exogenous expression of estrogen receptors in ER-negative cells led to a decrease of IL-8 levels. In summary, our data show that IL-8 expression is negatively linked to ER status of breast and ovarian cancer cells. We also support the idea that IL-8 expression is associated with a higher invasiveness potential of cancer cells in vitro, which suggests that IL-8 could be a novel marker of tumor aggressiveness.
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Contributor : Gwendal Lazennec Connect in order to contact the contributor
Submitted on : Friday, April 27, 2007 - 5:00:28 PM
Last modification on : Friday, September 9, 2022 - 10:20:08 AM
Long-term archiving on: : Wednesday, April 7, 2010 - 3:28:13 AM




Ariane Freund, Corine Chauveau, Jean-Paul Brouillet, Annick Lucas, Matthieu Lacroix, et al.. IL-8 expression and its possible relationship with estrogen-receptor-negative status of breast cancer cells.. Oncogene, Nature Publishing Group, 2003, 22 (2), pp.256-65. ⟨10.1038/sj.onc.1206113⟩. ⟨inserm-00143840⟩



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