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Injectable bone substitute using a hydrophilic polymer.

Abstract : We studied a new injectable biomaterial for bone and dental surgery consisting of a hydrophilic polymer as matrix and bioactive calcium phosphate (CaP) ceramics as fillers. This material is composed of complex fluids whose flow is determined by the laws of rheology. We investigated the macromolecular effects on this composite in a tube. The stability of the polymer and the mixture is essential to the production of a ready-to-use injectable biomaterial. These flow properties are necessary to obtain CaP bioactivity in a dental canal or bone defect during percutaneous surgery. Macromolecules provide spaces between CaP ceramic granules and facilitate the role of the biological agents of bone substitution.
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Contributor : Pierre Weiss <>
Submitted on : Friday, April 27, 2007 - 10:12:50 AM
Last modification on : Thursday, April 5, 2018 - 10:36:33 AM
Long-term archiving on: : Wednesday, April 7, 2010 - 12:32:06 AM


  • HAL Id : inserm-00143787, version 1
  • PUBMED : 10458279



Pierre Weiss, Olivier Gauthier, Jean-Michel Bouler, Gaël Grimandi, Guy Daculsi. Injectable bone substitute using a hydrophilic polymer.. BONE, Elsevier, 1999, 25 (2 Suppl), pp.67S-70S. ⟨inserm-00143787⟩



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