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Application of FT-IR microspectroscopy to the study of an injectable composite for bone and dental surgery.

Abstract : Hydroxypropylmethylcellulose (HPMC) of high-viscosity grade is used as a ligand for a bioactive calcium phosphate ceramic (the filler) in a ready-to-use injectable sterilized biomaterial for bone and dental surgery. Application of physico-chemical methods such as XPS, NMR, or Raman spectroscopy encounters difficulties when used to study such a multiphased material. This paper reports on the application of FT-IR microspectroscopy (FT-IRM) for the investigation of inorganic and organic phases of the rough composite and separated phases obtained by mechanical or chemical extraction methods. A comparison of FT-IRM with the conventional KBr pellet method was made and indicates that the macro and micro FT-IR methods are complementary: the former revealed new chemical groups not visualized with the KBr method whereas the latter detected the major compound of the blend. FT-IR microspectroscopy was revealed to be a powerful method of analysis that is complementary to other existing spectroscopic methods. Moreover, it is expected to be a useful tool in the study of biomaterials in biological samples.
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Contributor : Pierre Weiss <>
Submitted on : Thursday, April 26, 2007 - 10:35:27 PM
Last modification on : Thursday, April 5, 2018 - 10:36:33 AM
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  • HAL Id : inserm-00143786, version 1
  • PUBMED : 9641637



Pierre Weiss, Sylvain Bohic, Mieczyslaw Lapkowski, Guy Daculsi. Application of FT-IR microspectroscopy to the study of an injectable composite for bone and dental surgery.. Journal of Biomedical Materials Research, John Wiley & Sons, 1998, 41 (1), pp.167-70. ⟨inserm-00143786⟩



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