Skip to Main content Skip to Navigation
Journal articles

T cell chemotaxis and chemokine release after Staphylococcus aureus interaction with polarized airway epithelium.

Abstract : In response to bacterial infection, airway epithelium releases inflammatory mediators including cytokines and chemokines that lead to immune cell efflux and could stimulate the adaptive T cell immune response. The aim of our study was to analyze, in a double chamber culture, the chemokine changes in response to Staphylococcus aureus and their consequences for T cells. Our data show that S. aureus stimulates basolateral and apical release of IL-8 and eotaxin by airway epithelial cells. We also observed increased chemokine receptor expression on CD8+ and CD4+ T cells and enhanced chemotaxis of CD4+ T cells toward apical supernatant. Our data strongly suggest that S. aureus interaction with airway epithelium contributes to specific migration of T cells to inflamed sites.
Complete list of metadatas

https://www.hal.inserm.fr/inserm-00143314
Contributor : Philippe Birembaut <>
Submitted on : Wednesday, April 25, 2007 - 11:13:55 AM
Last modification on : Monday, July 2, 2018 - 4:08:06 PM

Identifiers

Collections

Citation

Sandie Escotte, Denise Al Alam, Richard Le Naour, Edith Puchelle, Moncef Guenounou, et al.. T cell chemotaxis and chemokine release after Staphylococcus aureus interaction with polarized airway epithelium.. American Journal of Respiratory Cell and Molecular Biology, American Thoracic Society, 2006, 34 (3), pp.348-54. ⟨10.1165/rcmb.2005-0191OC⟩. ⟨inserm-00143314⟩

Share

Metrics

Record views

177