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Tumor necrosis factor is a survival and proliferation factor for human myeloma cells.

Abstract : Interleukin-6 (IL-6) is a major survival factor for malignant plasma cells. In patients with multiple myeloma (MM), cell lines whose survival and proliferation are dependent upon addition of exogenous IL-6 have been obtained. We show here that tumor necrosis factor-alpha (TNF-alpha) is also a survival factor for myeloma cell lines, although less potent than IL-6. The survival activity of TNF-alpha is not affected by anti-IL-6 or anti-gp130 monoclonal antibodies (mAbs). TNF-alpha also induces myeloma cells in the cell cycle and promotes the long-term growth of malignant plasma cell lines. As TNF-alpha is produced in patients with MM and associated with a poor prognosis, these results suggest that anti-TNF-alpha therapies could be useful in this disease.
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Submitted on : Wednesday, April 18, 2007 - 2:13:04 PM
Last modification on : Friday, September 9, 2022 - 10:20:08 AM
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  • HAL Id : inserm-00142273, version 1
  • PUBMED : 10210775



Michel Jourdan, Karin Tarte, Eric Legouffe, Jean Brochier, Jean-François Rossi, et al.. Tumor necrosis factor is a survival and proliferation factor for human myeloma cells.. European Cytokine Network, John Libbey Eurotext, 1999, 10 (1), pp.65-70. ⟨inserm-00142273⟩



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