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Journal articles
Tumor necrosis factor is a survival and proliferation factor for human myeloma cells.
Abstract : Interleukin-6 (IL-6) is a major survival factor for malignant plasma cells. In patients with multiple myeloma (MM), cell lines whose survival and proliferation are dependent upon addition of exogenous IL-6 have been obtained. We show here that tumor necrosis factor-alpha (TNF-alpha) is also a survival factor for myeloma cell lines, although less potent than IL-6. The survival activity of TNF-alpha is not affected by anti-IL-6 or anti-gp130 monoclonal antibodies (mAbs). TNF-alpha also induces myeloma cells in the cell cycle and promotes the long-term growth of malignant plasma cell lines. As TNF-alpha is produced in patients with MM and associated with a poor prognosis, these results suggest that anti-TNF-alpha therapies could be useful in this disease.
Cited literature [3 references]
https://www.hal.inserm.fr/inserm-00142273
Contributor : Monique Frei <>
Submitted on : Wednesday, April 18, 2007 - 2:13:04 PM
Last modification on : Friday, May 15, 2020 - 12:22:03 PM
Long-term archiving on: : Tuesday, April 6, 2010 - 11:38:45 PM
Contributor : Monique Frei <>
Submitted on : Wednesday, April 18, 2007 - 2:13:04 PM
Last modification on : Friday, May 15, 2020 - 12:22:03 PM
Long-term archiving on: : Tuesday, April 6, 2010 - 11:38:45 PM