Tumor necrosis factor is a survival and proliferation factor for human myeloma cells.

Michel Jourdan 1 Karin Tarte 1 Eric Legouffe 2 Jean Brochier 1 Jean-François Rossi 2 Bernard Klein 1, 3, *
* Auteur correspondant
1 Immunopathologie des maladies tumorales et autoimmunes
2 Service d'hématologie et oncologie médicale
3 IRB - Institut de recherche en biothérapie
Abstract : Interleukin-6 (IL-6) is a major survival factor for malignant plasma cells. In patients with multiple myeloma (MM), cell lines whose survival and proliferation are dependent upon addition of exogenous IL-6 have been obtained. We show here that tumor necrosis factor-alpha (TNF-alpha) is also a survival factor for myeloma cell lines, although less potent than IL-6. The survival activity of TNF-alpha is not affected by anti-IL-6 or anti-gp130 monoclonal antibodies (mAbs). TNF-alpha also induces myeloma cells in the cell cycle and promotes the long-term growth of malignant plasma cell lines. As TNF-alpha is produced in patients with MM and associated with a poor prognosis, these results suggest that anti-TNF-alpha therapies could be useful in this disease.
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Article dans une revue
European Cytokine Network, John Libbey Eurotext, 1999, 10 (1), pp.65-70
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  • HAL Id : inserm-00142273, version 1
  • PUBMED : 10210775

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Michel Jourdan, Karin Tarte, Eric Legouffe, Jean Brochier, Jean-François Rossi, et al.. Tumor necrosis factor is a survival and proliferation factor for human myeloma cells.. European Cytokine Network, John Libbey Eurotext, 1999, 10 (1), pp.65-70. 〈inserm-00142273〉

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