Ca2+ currents in cardiac myocytes: Old story, new insights.

Abstract : Calcium is a ubiquitous second messenger which plays key roles in numerous physiological functions. In cardiac myocytes, Ca2+ crosses the plasma membrane via specialized voltage-gated Ca2+ channels which have two main functions: (i) carrying depolarizing current by allowing positively charged Ca2+ ions to move into the cell; (ii) triggering Ca2+ release from the sarcoplasmic reticulum. Recently, it has been suggested than Ca2+ channels also participate in excitation-transcription coupling. The purpose of this review is to discuss the physiological roles of Ca2+ currents in cardiac myocytes. Next, we describe local regulation of Ca2+ channels by cyclic nucleotides. We also provide an overview of recent studies investigating the structure-function relationship of Ca2+ channels in cardiac myocytes using heterologous system expression and transgenic mice, with descriptions of the recently discovered Ca2+ channels alpha(1D) and alpha(1E). We finally discuss the potential involvement of Ca2+ currents in cardiac pathologies, such as diseases with autoimmune components, and cardiac remodeling.
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Progress in Biophysics and Molecular Biology, Elsevier, 2006, 91 (1-2), pp.1-82. 〈10.1016/j.pbiomolbio.2005.01.001〉
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https://www.hal.inserm.fr/inserm-00141882
Contributeur : Jean-Yves Le Guennec <>
Soumis le : mercredi 1 août 2007 - 17:40:21
Dernière modification le : jeudi 7 février 2019 - 17:40:35
Document(s) archivé(s) le : mardi 6 avril 2010 - 22:36:14

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Fabien Brette, Jérôme Leroy, Jean-Yves Le Guennec, Laurent Sallé. Ca2+ currents in cardiac myocytes: Old story, new insights.. Progress in Biophysics and Molecular Biology, Elsevier, 2006, 91 (1-2), pp.1-82. 〈10.1016/j.pbiomolbio.2005.01.001〉. 〈inserm-00141882〉

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