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Ca2+ currents in cardiac myocytes: Old story, new insights.

Abstract : Calcium is a ubiquitous second messenger which plays key roles in numerous physiological functions. In cardiac myocytes, Ca2+ crosses the plasma membrane via specialized voltage-gated Ca2+ channels which have two main functions: (i) carrying depolarizing current by allowing positively charged Ca2+ ions to move into the cell; (ii) triggering Ca2+ release from the sarcoplasmic reticulum. Recently, it has been suggested than Ca2+ channels also participate in excitation-transcription coupling. The purpose of this review is to discuss the physiological roles of Ca2+ currents in cardiac myocytes. Next, we describe local regulation of Ca2+ channels by cyclic nucleotides. We also provide an overview of recent studies investigating the structure-function relationship of Ca2+ channels in cardiac myocytes using heterologous system expression and transgenic mice, with descriptions of the recently discovered Ca2+ channels alpha(1D) and alpha(1E). We finally discuss the potential involvement of Ca2+ currents in cardiac pathologies, such as diseases with autoimmune components, and cardiac remodeling.
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Contributor : Jean-Yves Le Guennec <>
Submitted on : Wednesday, August 1, 2007 - 5:40:21 PM
Last modification on : Wednesday, December 4, 2019 - 9:52:02 AM
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Fabien Brette, Jérôme Leroy, Jean-Yves Le Guennec, Laurent Sallé. Ca2+ currents in cardiac myocytes: Old story, new insights.. Progress in Biophysics and Molecular Biology, Elsevier, 2006, 91 (1-2), pp.1-82. ⟨10.1016/j.pbiomolbio.2005.01.001⟩. ⟨inserm-00141882⟩



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