Voltage-gated sodium channels: new targets in cancer therapy?

Sébastien Roger 1 Marie Potier 1 Christophe Vandier 1 Pierre Besson 1 Jean-Yves Le Guennec 1, *
* Corresponding author
1 N2C - Nutrition, croissance et cancer (U 1069)
Abstract : Early detection and treatment of cancers have increased survival and improved clinical outcome. The development of metastases is often associated with a poor prognostic of survival. Finding early markers of metastasis and developing new therapies against their development is a great challenge. Since a few years, there is more evidence that ionic channels are involved in the oncogenic process. Among these, voltage-gated sodium channels expressed in non-nervous or non-muscular organs are often associated with the metastatic behaviour of different cancers. The aim of this review is to describe the current knowledge on the functional expression of voltage-gated sodium channels and their biological roles in different cancers such as prostate, breast, lung (small cells and non-small cells) and leukaemia. In the conclusion, we develop conceptual approaches to understand how such channels can be involved in the metastatic process and conclude that blockers targeted toward these channels are promising new therapeutic solutions against metastatic cancers.
Document type :
Journal articles
Liste complète des métadonnées

Cited literature [32 references]  Display  Hide  Download
https://www.hal.inserm.fr/inserm-00141876
Contributor : Jean-Yves Le Guennec <>
Submitted on : Friday, November 13, 2009 - 11:07:48 AM
Last modification on : Monday, July 2, 2018 - 4:20:15 PM
Document(s) archivé(s) le : Wednesday, April 7, 2010 - 3:20:08 AM

Files

Roger_et_al_Curr_Pharm_Design_...

Identifiers

  • HAL Id : inserm-00141876, version 1
  • PUBMED : 17073667

Collections

UNIV-TOURS

Citation

Sébastien Roger, Marie Potier, Christophe Vandier, Pierre Besson, Jean-Yves Le Guennec. Voltage-gated sodium channels: new targets in cancer therapy?. Current Pharmaceutical Design, Bentham Science Publishers, 2006, 12 (28), pp.3681-95. ⟨inserm-00141876⟩

Export

BibTeX TEI DC DCterms EndNote

Share

Metrics

Record views

103

Files downloads

1227

Contact

support.ccsd.cnrs.fr
hal.support@ccsd.cnrs.fr
Logo CCSD