Skip to Main content Skip to Navigation
Journal articles

Genetic control of thymic development of CD4+CD25+FoxP3+ regulatory T lymphocytes.

Abstract : Among the several mechanisms known to be involved in the establishment and maintenance of immunological tolerance, the activity of CD4+CD25+ regulatory T lymphocytes has recently incited most interest because of its critical role in inhibition of autoimmunity and anti-tumor immunity. Surprisingly, very little is known about potential genetic modulation of intrathymic regulatory T lymphocyte development. We show that distinct proportions of CD4+CD25+FoxP3+ regulatory T cells are found in thymi of common laboratory mouse strains. We demonstrate that distinct levels of phenotypically identical regulatory T cells develop with similar kinetics in the mice studied. Our experimental data on congenic mouse strains indicate that differences are not caused by the distinct MHC haplotypes of the inbred mouse strains. Moreover, the responsible loci act in a thymocyte-intrinsic manner, confirming the latter conclusion. We have not found any correlation between thymic and peripheral levels of regulatory T cells, consistent with known homeostatic expansion and/or retraction of the peripheral regulatory T cell pool. Our data indicate that polymorphic genes modulate differentiation of regulatory T cells. Identification of responsible genes may reveal novel clinical targets and still elusive regulatory T cell-specific markers. Importantly, these genes may also modulate susceptibility to autoimmune disease.
Document type :
Journal articles
Complete list of metadatas

Cited literature [5 references]  Display  Hide  Download

https://www.hal.inserm.fr/inserm-00140908
Contributor : Joost van Meerwijk <>
Submitted on : Friday, September 4, 2009 - 1:59:33 PM
Last modification on : Tuesday, February 18, 2020 - 3:32:02 PM
Long-term archiving on: : Tuesday, April 6, 2010 - 10:42:01 PM

Identifiers

Collections

Citation

Paola Romagnoli, Julie Tellier, Joost van Meerwijk. Genetic control of thymic development of CD4+CD25+FoxP3+ regulatory T lymphocytes.. European Journal of Immunology, Wiley-VCH Verlag, 2005, 35 (12), pp.3525-32. ⟨10.1002/eji.200535225⟩. ⟨inserm-00140908⟩

Share

Metrics

Record views

203

Files downloads

1255