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CD4(+)CD25(+) regulatory T lymphocytes in bone marrow transplantation.

Abstract : Induction of immunological tolerance to alloantigens would be the treatment of choice to prevent graft-versus-host disease (GvHD) and allograft rejection in transplantation medicine. Organisms use a variety of mechanisms to avoid potentially deadly immunity to self-antigens. The most potent self-tolerance mechanism is probably dominant tolerance assured by regulatory and suppressor T lymphocytes. It appears therefore attractive to use the same mechanism to induce transplantation-tolerance. We here review and discuss recent advances in the use of one of the best-characterized regulatory T lymphocyte populations, CD4(+)CD25(+) T cells, to prevent graft-versus-host disease and bone marrow allograft rejection.
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Submitted on : Tuesday, April 10, 2007 - 4:54:16 PM
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Olivier Joffre, Joost Pm van Meerwijk. CD4(+)CD25(+) regulatory T lymphocytes in bone marrow transplantation.. Seminars in Immunology, Elsevier, 2006, 18 (2), pp.128-35. ⟨10.1016/j.smim.2006.01.005⟩. ⟨inserm-00140906⟩



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