Skip to Main content Skip to Navigation
Journal articles

An MHC-linked locus modulates thymic differentiation of CD4+CD25+Foxp3+ regulatory T lymphocytes.

Abstract : CD4+CD25+Foxp3+ regulatory T lymphocytes are crucial for maintenance of immunological tolerance to self and innocuous non-self, are known to modulate immunity to tumors and infectious agents and can induce transplantation tolerance. Surprisingly, only a single genetic polymorphism is known to modulate regulatory T cell (Treg) development in the thymus, leading to a lethal autoimmune disorder. Here, we show that considerably different levels of Tregs are found in the thymi of distinct common laboratory mouse strains. We demonstrate that distinct levels of phenotypically and functionally identical Tregs develop with similar kinetics in the studied mice, that the responsible locus acts in a thymocyte-intrinsic manner and that levels of thymic Foxp3+ Tregs correlate to those found in the periphery. Using several congenic mouse strains, we mapped one of the at least two genetic loci capable of quantitatively modulating thymic Treg development to a
Document type :
Journal articles
Complete list of metadatas

Cited literature [34 references]  Display  Hide  Download

https://www.hal.inserm.fr/inserm-00140905
Contributor : Joost van Meerwijk <>
Submitted on : Monday, October 15, 2007 - 3:25:37 PM
Last modification on : Tuesday, February 18, 2020 - 3:32:02 PM
Long-term archiving on: : Wednesday, April 7, 2010 - 3:15:54 AM

Identifiers

Collections

Citation

Julie Tellier, Joost van Meerwijk, Paola Romagnoli. An MHC-linked locus modulates thymic differentiation of CD4+CD25+Foxp3+ regulatory T lymphocytes.. International Immunology, Oxford University Press (OUP), 2006, 18 (11), pp.1509-19. ⟨10.1093/intimm/dxl084⟩. ⟨inserm-00140905⟩

Share

Metrics

Record views

238

Files downloads

703