Central tolerance: learning self-control in the thymus, Nature Reviews Immunology, vol.174, issue.10, pp.772-782377, 1997. ,
DOI : 10.1038/nri1707
Impact of Negative Selection on the T Cell Repertoire Reactive to a Self-Peptide, Immunity, vol.13, issue.6, pp.829-840, 2000. ,
DOI : 10.1016/S1074-7613(00)00080-7
T Lymphocyte Tolerance: From Thymic Deletion to Peripheral Control Mechanisms, Adv. Immunol, vol.71, pp.229-265, 1999. ,
DOI : 10.1016/S0065-2776(08)60404-6
Cornerstone of peripheral tolerance: naturally occurring CD4+CD25+ regulatory T cells, Trends in Immunology, vol.25, issue.7, pp.374-380, 2004. ,
DOI : 10.1016/j.it.2004.04.009
Foxp3 and Natural Regulatory T Cells, Immunity, vol.19, issue.2, pp.165-168, 2003. ,
DOI : 10.1016/S1074-7613(03)00207-3
Regulatory T Cell Lineage Specification by the Forkhead Transcription Factor Foxp3, Immunity, vol.22, issue.3, pp.329-341, 2005. ,
DOI : 10.1016/j.immuni.2005.01.016
Regulatory T cells and intestinal homeostasis, Immunological Reviews, vol.173, issue.1, pp.184-194, 2005. ,
DOI : 10.1084/jem.186.7.1099
Regulatory T cells: friend or foe in immunity to infection?, Nature Reviews Immunology, vol.170, issue.11, pp.841-855, 2004. ,
DOI : 10.1002/1521-4141(200211)32:11<3267::AID-IMMU3267>3.0.CO;2-1
Regulatory T cells mediate maternal tolerance to the fetus, Nature Immunology, vol.420, issue.3, pp.266-271, 2004. ,
DOI : 10.1038/ni1037
Immunoregulatory T cells in tumor immunity, Current Opinion in Immunology, vol.16, issue.2, pp.157-162, 2004. ,
DOI : 10.1016/j.coi.2004.01.010
Molecular Signature of Recent Thymic Selection Events on Effector and Regulatory CD4+ T Lymphocytes, The Journal of Immunology, vol.175, issue.9, pp.5751-5758, 2005. ,
DOI : 10.4049/jimmunol.175.9.5751
URL : https://hal.archives-ouvertes.fr/inserm-00140915
Preferential Recognition of Self Antigens Despite Normal Thymic Deletion of CD4+CD25+ Regulatory T Cells, The Journal of Immunology, vol.168, issue.4, pp.1644-1648, 2002. ,
DOI : 10.4049/jimmunol.168.4.1644
Regulatory T Cells in the Steady State, The Journal of Experimental Medicine, vol.158, issue.5, pp.737-746, 2003. ,
DOI : 10.1111/j.1600-065X.1996.tb00901.x
Recognition of the Peripheral Self by Naturally Arising CD25+ CD4+ T Cell Receptors, Immunity, vol.21, issue.2, pp.267-277, 2004. ,
DOI : 10.1016/j.immuni.2004.07.009
Immunoregulatory T Cells, The Journal of Experimental Medicine, vol.132, issue.4, pp.427-438, 2001. ,
DOI : 10.1038/79790
Peptide Specificity of Thymic Selection of CD4+CD25+ T Cells, The Journal of Immunology, vol.168, issue.2, pp.613-620, 2002. ,
DOI : 10.4049/jimmunol.168.2.613
Number of T Reg Cells That Differentiate Does Not Increase upon Encounter of Agonist Ligand on Thymic Epithelial Cells, HAL author manuscript inserm-00140891, pp.1221-1230, 2004. ,
DOI : 10.1016/S0960-9822(99)80093-1
Evidence for a Thymus-Dependent Form of Tolerance that is Not Based on Elimination or Anergy of Reactive T cells, Immunological Reviews, vol.14, issue.1, pp.35-534399, 1996. ,
DOI : 10.1016/0092-8674(88)90156-0
Origin of regulatory T cells with known specificity for antigen, Nature Immunology, vol.3, pp.756-763, 2002. ,
DOI : 10.1038/ni816
Anergy and suppression regulate CD4+ T cell responses to a self peptide, European Journal of Immunology, vol.30, issue.1, pp.136-144, 2000. ,
DOI : 10.1002/1521-4141(200001)30:1<136::AID-IMMU136>3.0.CO;2-0
Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide, Nature Immunology, vol.180, issue.4, pp.301-306, 2001. ,
DOI : 10.1038/86302
Development and function of agonist-induced CD25+Foxp3+ regulatory T cells in the absence of interleukin 2 signaling, Nature Immunology, vol.172, issue.11, pp.1152-1159, 2005. ,
DOI : 10.1016/j.micinf.2004.02.020
Normal development of mice deficient in beta 2M, MHC class I proteins, and CD8+ T cells, Science, vol.248, issue.4960, pp.1227-1230, 1990. ,
DOI : 10.1126/science.2112266
Another view of the selective model of thymocyte selection, Cell, vol.73, issue.2, pp.225-236, 1993. ,
DOI : 10.1016/0092-8674(93)90225-F
Characterization of a monoclonal antibody directed against mouse macrophage and lymphocyte Fc receptors, Journal of Experimental Medicine, vol.150, issue.3, pp.580-596, 1979. ,
DOI : 10.1084/jem.150.3.580
Cloned T Lymphocytes and Monoclonal Antibodies as Probes for Cell Surface Molecules Active in T Cell-Mediated Cytolysis, Immunological Reviews, vol.40, issue.1, pp.135-169, 1982. ,
DOI : 10.1084/jem.154.5.1517
Mouse Mammary Tumor Virus: Immunological Interplays between Virus and Host **This article was accepted for publication on 1 October 1996., Adv. Immunol, vol.65, pp.139-243, 1997. ,
DOI : 10.1016/S0065-2776(08)60743-9
Genetic control of thymic development of CD4+CD25+FoxP3+ regulatory T???lymphocytes, European Journal of Immunology, vol.173, issue.12, pp.3525-3532, 2005. ,
DOI : 10.1002/eji.200535225
URL : https://hal.archives-ouvertes.fr/inserm-00140908
A nondeletional mechanism of thymic self tolerance, Science, vol.246, issue.4933, pp.1038-1041, 1989. ,
DOI : 10.1126/science.2511629
Sampling of complementing self-antigen pools by thymic stromal cells maximizes the scope of central T cell tolerance, European Journal of Immunology, vol.183, issue.8, pp.2476-24861039, 2001. ,
DOI : 10.1002/1521-4141(200108)31:8<2476::AID-IMMU2476>3.0.CO;2-T
Immunologic selftolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25) Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases, J. Immunol, vol.155, pp.1151-1164, 1995. ,
A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3, Nature Immunology, vol.14, issue.4, pp.331-337, 2005. ,
DOI : 10.1093/intimm/dxh165
Developmental regulation of Foxp3 expression during ontogeny, The Journal of Experimental Medicine, vol.105, issue.7, pp.901-906, 2005. ,
DOI : 10.1080/0891693031000116057
Homeostatic maintenance of natural Foxp3(+) CD25(+) CD4(+) regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization Unexpectedly complex regulation of CD4/CD8 coreceptor expression supports a revised model for CD4+CD8+ thymocyte differentiation Evidence for lineage commitment and initiation of positive selection by thymocytes with intermediate surface phenotypes, J. Exp. Med. Immunity J. Immunol, vol.201, issue.154, pp.723-735461, 1995. ,
Clonal deletion versus clonal anergy: the role of the thymus in inducing self tolerance Antigendependent Proliferation of CD4+ CD25+ Regulatory T Cells In Vivo Homeostasis limits the development of mature CD8+ but not CD4+ thymocytes, Science J. Exp. Med. J. Immunol, vol.248, issue.160, pp.1342-1348249, 1990. ,
Class I and class II MHC gene products differentially affect the fate of V beta 5 bearing thymocytes, J Mol Cell Immunol, vol.4, pp.269-279, 1990. ,
Expression of the V beta 5.1 gene by murine peripheral T cells is controlled by MHC genes and skewed to the CD8+ subset Chronic modulation of the TCR repertoire in the lymphoid periphery, J. Immunol. J. Immunol, vol.144, issue.162, pp.844-8483131, 1990. ,
Human CD4+CD25+ Regulatory T Cells Share Equally Complex and Comparable Repertoires with CD4+CD25- Counterparts, The Journal of Immunology, vol.172, issue.10, pp.6123-6128, 2004. ,
DOI : 10.4049/jimmunol.172.10.6123
Positive selection of T cells: rescue from programmed cell death and differentiation require continual engagement of the T cell receptor, Journal of Experimental Medicine, vol.181, issue.6, pp.1975-1984, 1995. ,
DOI : 10.1084/jem.181.6.1975
Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self, Nature Immunology, vol.25, issue.11, pp.1032-1039, 2001. ,
DOI : 10.1038/ni723