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Ion channels in death and differentiation of prostate cancer cells.

Abstract : Plasma membrane ion channels contribute to virtually all basic cellular processes, including such crucial ones for maintaining tissue homeostasis as proliferation, differentiation, and apoptosis. Enhanced proliferation, aberrant differentiation, and impaired ability to die are the prime reasons for abnormal tissue growth, which can eventually turn into uncontrolled expansion and invasion, characteristic of cancer. Prostate cancer (PCa) cells express a variety of plasma membrane ion channels. By providing the influx of essential signaling ions, perturbing intracellular ion concentrations, regulating cell volume, and maintaining membrane potential, PCa cells are critically involved in proliferation, differentiation, and apoptosis. PCa cells of varying metastatic ability can be distinguished by their ion channel characteristics. Increased malignancy and invasiveness of androgen-independent PCa cells is generally associated with the shift to a 'more excitable' phenotype of their plasma membrane. This shift is manifested by the appearance of voltage-gated Na(+) and Ca(2+) channels which contribute to their enhanced apoptotic resistance together with downregulated store-operated Ca(2+) influx, altered expression of different K(+) channels and members of the Transient Receptor Potential (TRP) channel family, and strengthened capability for maintaining volume constancy. The present review examines channel types expressed by PCa cells and their involvement in metastatic behaviors.Cell Death and Differentiation advance online publication, 4 May 2007; doi:10.1038/sj.cdd.4402162.
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Contributor : Matthieu Flourakis Connect in order to contact the contributor
Submitted on : Wednesday, November 7, 2007 - 9:41:00 AM
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Natalia Prevarskaya, Roman Skryma, Gabriel Bidaux, Matthieu Flourakis, Yaroslav Shuba. Ion channels in death and differentiation of prostate cancer cells.. Cell Death and Differentiation, Nature Publishing Group, 2007, 14 (7), pp.1295-304. ⟨10.1038/sj.cdd.4402162⟩. ⟨inserm-00140045⟩



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