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A review of epidemiologic studies on aluminum and silica in relation to Alzheimer's disease and associated disorders.

Abstract : Although the neurotoxicity of aluminum is well established, the association between the metal and dementia or associated disorders remains a subject of debate. In this article, we present a review of articles published on epidemiologic studies of this subject. Different sources of exposure are considered (occupational exposure, aluminum-containing products), with emphasis on drinking water. We separate the various health effects of aluminum into three categories: neurological disorders (other than cognitive decline or AD); cognitive decline; and dementia or Alzheimer's disease. Furthermore, we present the results obtained on silicon in drinking water, a chemical constituent that interacts with aluminum. We conclude that not enough epidemiological evidence supports a link between aluminum in drinking water and AD. The role of silica in drinking water has been less studied, and clear results have not yet emerged.
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https://www.hal.inserm.fr/inserm-00138550
Contributor : Virginie Rondeau <>
Submitted on : Tuesday, March 27, 2007 - 2:06:38 PM
Last modification on : Friday, December 18, 2015 - 1:08:03 AM
Long-term archiving on: : Friday, November 25, 2016 - 2:27:02 PM

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Virginie Rondeau. A review of epidemiologic studies on aluminum and silica in relation to Alzheimer's disease and associated disorders.. Reviews on Environmental Health, Walter de Gruyter, 2002, 17 (2), pp.107-21. ⟨inserm-00138550⟩

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