J. Baum, J. Bookstein, F. Holtz, and E. Klein, Possible association between benign hepatomas and oral contraceptives, Lancet, vol.2, pp.926-935, 1973.

H. Edmondson, B. Henderson, and B. B. , Liver-Cell Adenomas Associated with Use of Oral Contraceptives, New England Journal of Medicine, vol.294, issue.9, pp.470-472, 1976.
DOI : 10.1056/NEJM197602262940904

J. Flejou, J. Barge, and Y. Menu, Liver adenomatosis, Gastroenterology, vol.89, issue.5, pp.1132-1140, 1985.
DOI : 10.1016/0016-5085(85)90220-3

H. Buhler, M. Pirovino, and A. Akobiantz, Regression of liver cell adenoma. A follow-up study of three consecutive patients after discontinuation of oral contraceptive use, Gastroenterology, vol.82, pp.775-82, 1982.

H. Edmondson, T. Reynolds, B. Henderson, and B. B. , Regression of Liver Cell Adenomas Associated with Oral Contraceptives, Annals of Internal Medicine, vol.86, issue.2, pp.180-182, 1977.
DOI : 10.7326/0003-4819-86-2-180

O. Bluteau, E. Jeannot, and P. Bioulac-sage, Bi-allelic inactivation of TCF1 in hepatic adenomas, Nature Genetics, vol.120, issue.2, pp.312-317, 2002.
DOI : 10.1038/35057062

Y. Chen, Y. Jeng, S. Yeh, and C. Pj, p53 gene and Wnt signaling in benign neoplasms: ??-catenin mutations in hepatic adenoma but not in focal nodular hyperplasia, Hepatology, vol.13, issue.4, pp.927-962, 2002.
DOI : 10.1053/jhep.2002.36126

J. Zucman-rossi, E. Jeannot, and J. Nhieu, Genotype???phenotype correlation in hepatocellular adenoma: New classification and relationship with HCC, Hepatology, vol.41, issue.3, pp.515-539, 2006.
DOI : 10.1002/hep.21068
URL : https://hal.archives-ouvertes.fr/inserm-00130314

Y. Bacq, E. Jacquemin, and C. Balabaud, Familia liver adenomatosis associated with hepatocyte nuclear factor 1?? inactivation1 1The authors thank Leigh Pascoe for critical reading of the manuscript, H??l??ne Blanch?? and Hung Bui of the CEPH/Fondation Jean Dausset for technical help in sequencing, and Drs. A. Saillant, E. Akodjenou, and E. Urvoas (Pediatric and Radiology Units, H??pitaux de Chartres, France) for referring patient B1 to E.J. and for performing liver ultrasound screening in family B., Gastroenterology, vol.125, issue.5, pp.1470-1475, 2003.
DOI : 10.1016/j.gastro.2003.07.012

Y. Reznik, T. Dao, and R. Coutant, Hepatocyte Nuclear Factor-1?? Gene Inactivation: Cosegregation between Liver Adenomatosis and Diabetes Phenotypes in Two Maturity-Onset Diabetes of the Young (MODY)3 Families, The Journal of Clinical Endocrinology & Metabolism, vol.89, issue.3, pp.1476-80, 2004.
DOI : 10.1210/jc.2003-031552

P. Bioulac-sage, S. Rebouissou, S. Cunha, and A. , Clinical, Morphologic, and Molecular Features Defining So-Called Telangiectatic Focal Nodular Hyperplasias of the Liver, Gastroenterology, vol.128, issue.5, pp.1211-1219, 2005.
DOI : 10.1053/j.gastro.2005.02.004

H. Cann, C. De-toma, and L. Cazes, A Human Genome Diversity Cell Line Panel, Science, vol.296, issue.5566, pp.261-263, 2002.
DOI : 10.1126/science.296.5566.261b

A. Cabelguenne, M. Loriot, and I. Stucker, Glutathione-associated enzymes in head and neck squamous cell carcinoma and response to cisplatin-based neoadjuvant chemotherapy, International Journal of Cancer, vol.18, issue.5, pp.725-755, 2001.
DOI : 10.1002/ijc.1392

S. Ding, D. Yao, and Y. Deeni, Human NADPH-P450 oxidoreductase modulates the level of cytochrome P450 CYP2D6 holoprotein via haem oxygenase-dependent and -independent pathways, Biochemical Journal, vol.356, issue.2, pp.613-622, 2001.
DOI : 10.1042/bj3560613

S. Bandiera, S. Weidlich, and V. Harth, Proteasomal Degradation of Human CYP1B1: Effect of the Asn453Ser Polymorphism on the Post-Translational Regulation of CYP1B1 Expression, Molecular Pharmacology, vol.67, issue.2, pp.435-478, 2005.
DOI : 10.1124/mol.104.006056

D. Li, A. Seidel, M. Pritchard, C. Wolf, and T. Friedberg, Polymorphisms in P450 CYP1B1 affect the conversion of estradiol to the potentially carcinogenic metabolite 4-hydroxyestradiol, Pharmacogenetics, vol.10, issue.4, pp.343-53, 2000.
DOI : 10.1097/00008571-200006000-00008

J. Watanabe, T. Shimada, and E. Gillam, Association of CYP1B1 genetic polymorphism with incidence to breast and lung cancer, Pharmacogenetics, vol.10, issue.1, pp.25-33, 2000.
DOI : 10.1097/00008571-200002000-00004

I. Stoilov, A. Akarsu, and M. Sarfarazi, Identification of three different truncating mutations in cytochrome P4501B1 (CYP1B1) as the principal cause of primary congenital glaucoma (Buphthalmos) in families linked to the GLC3A locus on chromosome 2p21, Human Molecular Genetics, vol.6, issue.4, pp.641-648, 1997.
DOI : 10.1093/hmg/6.4.641

M. Sarfarazi, A. Akarsu, and A. Hossain, Assignment of a Locus (GLC3A) for Primary Congenital Glaucoma (Buphthalmos) to 2p21 and Evidence for Genetic Heterogeneity, Genomics, vol.30, issue.2, pp.171-178, 1995.
DOI : 10.1006/geno.1995.9888

M. Lopez-garrido, F. Sanchez-sanchez, and F. Lopez-martinez, Heterozygous CYP1B1 gene mutations in Spanish patients with primary open-angle glaucoma, Mol Vis, vol.12, pp.748-55, 2006.

T. Sissung, D. Price, A. Sparreboom, and W. Figg, Pharmacogenetics and Regulation of Human Cytochrome P450 1B1: Implications in Hormone-Mediated Tumor Metabolism and a Novel Target for Therapeutic Intervention, Molecular Cancer Research, vol.4, issue.3, pp.135-50, 2006.
DOI : 10.1158/1541-7786.MCR-05-0101

C. Hayes, D. Spink, and B. Spink, 17 beta-estradiol hydroxylation catalyzed by human cytochrome P450 1B1., Proceedings of the National Academy of Sciences, vol.93, issue.18, pp.9776-81, 1996.
DOI : 10.1073/pnas.93.18.9776

J. Liehr and M. Ricci, 4-Hydroxylation of estrogens as marker of human mammary tumors., Proceedings of the National Academy of Sciences, vol.93, issue.8, pp.3294-3300, 1996.
DOI : 10.1073/pnas.93.8.3294

M. Mcfadyen, S. Breeman, and S. Payne, Immunohistochemical Localization of Cytochrome P450 CYP1B1 in Breast Cancer with Monoclonal Antibodies Specific for CYP1B1, Journal of Histochemistry & Cytochemistry, vol.26, issue.11, pp.1457-64, 1999.
DOI : 10.1136/gut.43.6.791

G. Murray, M. Taylor, and M. Mcfadyen, Tumor-specific expression of cytochrome P450 CYP1B1, Cancer Res, vol.57, pp.3026-3057, 1997.

L. Muskhelishvili, P. Thompson, D. Kusewitt, C. Wang, and F. Kadlubar, In Situ Hybridization and Immunohistochemical Analysis of Cytochrome P450 1B1 Expression in Human Normal Tissues, Journal of Histochemistry & Cytochemistry, vol.122, issue.2, pp.229-265, 2001.
DOI : 10.1093/carcin/18.2.391