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Hodgkin's disease incidence and survival in European children and adolescents (1978-1997): report from the Automated Cancer Information System project.

Abstract : This paper reports the geographical patterns and time trends of incidence and survival of Hodgkin's disease (HD) in children and adolescents in Europe over the period 1978-1997. Data on 4230 HD cases were gathered from 62 paediatric or general cancer registries in 19 European countries by the Automated Cancer Information System (ACCIS). European annual incidence rates in 1988-1997 were estimated at 5.8 per million in children (world age-standardised) and at 29.7 per million in adolescents, with higher rates in the East and South. Incidence rates increased steeply with age, while the male predominance, marked for the youngest children, vanished in the highest age groups. Over the period 1978-1997 incidence rates increased in age groups 10-14 years (+1% per year) and 15-19 years (+3.5% per year), mainly due to the nodular sclerosis subtype. Age and sex distribution of cases remained unchanged with time. The overall 5-year survival rate was higher in children (93%, 95% confidence interval (CI) 92-94) than in adolescents (89% (95% CI 87-91)) for the period 1988-1997. Five-year survival increased significantly in all regions from 87% to 93% in children and from 80% to 88% in adolescents between 1978-1982 and 1993-1997. In future, detailed documentation of cases in the cancer registries with respect to standardised diagnostic subtypes, stage of extension, and treatments, will help to refine interpretation of international and temporal variations in incidence and survival.
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https://www.hal.inserm.fr/inserm-00137970
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Submitted on : Thursday, March 22, 2007 - 5:41:47 PM
Last modification on : Wednesday, October 14, 2020 - 4:10:14 AM

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Jacqueline Clavel, Eva Steliarova-Foucher, Claire Berger, Shemuel Danon, Zdravka Valerianova. Hodgkin's disease incidence and survival in European children and adolescents (1978-1997): report from the Automated Cancer Information System project.. European Journal of Cancer, Elsevier, 2006, 42 (13), pp.2037-49. ⟨10.1016/j.ejca.2006.05.012⟩. ⟨inserm-00137970⟩

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