N. Allbritton, T. Meyer, L. Stryer, S. Xu, D. Mchugh et al., Range of messenger action of calcium ion and inositol 1,4,5-trisphosphate TRPC1 store-operated cationic channel subunit, Science Beech DJ Cell Calcium, vol.258, issue.33, pp.1812-1815, 1992.

C. Benning and N. Kyprianou, Quinazoline-derived alpha1-adrenoceptor antagonists induce prostate cancer cell apoptosis via an alpha1-adrenoceptor-independent action, Cancer Res, vol.62, pp.597-602, 2002.

M. Berridge, M. Bootman, and P. Lipp, Calcium--a life and death signal, Nature, pp.645-648, 1998.

M. Caine, Alpha-adrenergic blockers for the treatment of benign prostatic hyperplasia

D. Clapham, Calcium signaling, Cell, vol.80, issue.2, pp.259-268, 1995.
DOI : 10.1016/0092-8674(95)90408-5

D. Clapham, TRP channels as cellular sensors, Nature, vol.426, issue.6966, pp.517-524, 2003.
DOI : 10.1038/nature02196

G. C. Crabtree, R. Dolmetsch, K. Xu, and R. Lewis, calcineurin, and the control of transcription Calcium oscillations increase the efficiency and specificity of gene expression, J Biol Chem Nature Estacion M, vol.276, issue.392 10, pp.2313-2316, 1998.

W. Schilling, W. Fang, F. Pirnia, Y. Bang, C. Myers et al., Activation of human TRPC6 channels by receptor stimulation P2-purinergic receptor agonists inhibit the growth of androgen-independent prostate carcinoma cells, J Biol Chem J Clin Invest, vol.279, issue.89, pp.22047-22056, 1992.

Y. Ohmori and S. Ueda, Carbon-11 labeled diacylglycerol for signal transduction imaging by positron CT: evaluation of the quality and safety for clinical use], Kaku Igaku, vol.32, pp.191-198, 1995.

V. Golovina, V. Golovina, O. Platoshyn, C. Bailey, J. Wang et al., Upregulated TRP and enhanced capacitative Ca(2+) entry in human pulmonary artery myocytes during proliferation A new generation of Ca2+ indicators with greatly improved fluorescence properties Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol LNCaP model of human prostatic carcinoma, Cell proliferation is associated with enhanced capacitative Ca(2+) entry in human arterial myocytes, pp.343-349, 1983.

N. Kyprianou, J. Chon, and C. Benning, Effects of Alpha(1)-adrenoceptor (alpha(1)-AR) antagonists on cell proliferation and apoptosis in the prostate: therapeutic implications in prostatic disease, Process Citation]. Prostate, pp.42-46, 1921.

X. Li, G. Stark, I. Marshall, R. Burt, C. Chapple et al., NFkappaB-dependent signaling pathways Signal transduction pathways associated with alpha1-adrenoceptor subtypes in cells and tissues including human prostate Calcineurin directs the reciprocal regulation of calcium entry pathways in nonexcitable cells Reciprocal regulation of capacitative and arachidonate-regulated noncapacitative Ca2+ entry pathways, Exp Hematol Eur Urol J Biol Chem J Biol Chem, vol.30, issue.276, pp.285-296, 2001.

K. Minneman, Alpha 1-adrenergic receptor subtypes, inositol phosphates, and sources of cell Ca2+, Pharmacol Rev, vol.40, pp.87-119, 1926.

C. P. Montell, R. Patterson, D. Van-rossum, D. Ford, K. Hurt et al., Phospholipase C-gamma is required for agonist-induced Ca2+ entry, TRP superfamily of cation channels. Sci STKE Cell, vol.27, issue.111, pp.1-529, 2001.

K. Pattni, T. Millard, G. C. Banting, J. Putney, J. Broad et al., TRPC4 and TRPC5: receptor-operated Ca2+-permeable nonselective cation channels Mechanisms of capacitative calcium entry Receptor-operated Ca2+ entry mediated by TRPC3/TRPC6 proteins in rat prostate smooth muscle (PS1) cell line 32. Sims CE and Allbritton NL. Metabolism of inositol 1,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate by the oocytes of Xenopus laevis Store depletion and store-operated Ca2+ current in human prostate cancer LNCaP cells: involvement in apoptosis Potassium conductance in the androgen-sensitive prostate cancer cell line, LNCaP: involvement in cell proliferation Inhibition of endogenous TRP1 decreases capacitative Ca2+ entry and attenuates pulmonary artery smooth muscle cell proliferation, isoform of Ins(1,4,5)P3 3-kinase separates the catalytic domain from the membrane anchoring domain A, and Malumbres M. Cooperation between Cdk4 and p27kip1 in tumor development: a preclinical model to evaluate cell cycle inhibitors with therapeutic activity, pp.643-651, 1997.

V. Sydorenko, Y. Shuba, S. Thebault, M. Roudbaraki, G. Lepage et al., Receptor-coupled, DAG-gated Ca2+-permeable cationic channels in LNCaP human prostate cancer epithelial cells Alpha1-adrenergic receptors activate Ca(2+)-permeable cationic channels in prostate cancer epithelial cells Signaling mechanism for receptor-activated TRPC3 channels, J Physiol J Clin Invest J Biol Chem, vol.548, issue.111, pp.823-836, 2003.

J. Schalken, F. Vanden-abeele, L. Lemonnier, S. Thebault, G. Lepage et al., Expression of basal cell keratins in human prostate cancer metastases and cell lines Two types of store-operated Ca2+ channels with different activation modes and molecular origin in LNCaP human prostate cancer epithelial cells, J Pathol J Biol Chem, vol.195, issue.41, pp.563-570, 2001.

F. Vanden-abeele, R. Skryma, Y. Shuba, F. Van-coppenolle, C. Slomianny et al., ROLE OF ENDOGENOUS Ca2+ TRANSPORTER TYPE 1 Bcl-2-dependent modulation of Ca(2+) homeostasis and store-operated channels in prostate cancer cells, Store-operated Ca2+ Current in Prostate Cancer Epithelial Cells, pp.15381-15389, 2002.

P. Wang, S. Alousi, A. Thompson, S. Yu, Y. Sweeney et al., The lifetime of inositol 1,4,5- trisphosphate in single cells PDGF stimulates pulmonary vascular smooth muscle cell proliferation by upregulating TRPC6 expression PCR primers hTRPC1 Forward : 5'-AGTGGGAACGACTCATCCTTTT-3', TRPC1A) hTRPC3 Forward : 5'-CTTCTCTAGGTCCATGGAGGGAA-3, pp.75-85, 1995.

. Backward1, AF063822) hTRPC4 Forward2 : 5'-CTCTGGTTGTTCTACTCAACATG-3' 2058-2082 (AF063822) 781 (TRPC4) Backward2 : 5'-CCTGTTGACGAGCAACTTCTTCT-3', AF063822), vol.528, issue.356TRPC4?, pp.659-636

. Backward1, AJ006276) hTRPC6 Forward2 : 5'-GAACTTAGCAATGAACTGGCAGT-3', pp.627-604