Skip to Main content Skip to Navigation
Journal articles

Evaluation of methods to detect interhemispheric asymmetry on cerebral perfusion SPECT: application to epilepsy.

Abstract : Detecting perfusion interhemispheric asymmetry in neurologic nuclear medicine imaging is an interesting approach to epilepsy. METHODS: This study compared 4 methods that detect interhemispheric asymmetries of brain perfusion in SPECT. The first (M1) was conventional side-by-side expert-based visual interpretation of SPECT. The second (M2) was visual interpretation assisted by an interhemispheric difference (IHD) volume. The last 2 were automatic methods: unsupervised analysis using volumes of interest (M3) and unsupervised analysis of the IHD volume (M4). Use of these methods to detect possible perfusion asymmetry was compared on 60 simulated SPECT datasets by controlling the presence and location of asymmetries. From the detection results, localization receiver operating characteristic curves were generated and areas under curves were estimated and compared. Finally, the methods were applied to analyze interictal SPECT datasets to localize the epileptogenic focus in temporal lobe epilepsies. RESULTS: This study showed an improvement in asymmetry detection on SPECT images with the methods using IHD volume (M2 and M4), in comparison with the other methods (M1 and M3). However, the most useful method for analyzing clinical SPECT datasets appeared to be visual inspection assisted by the IHD volume, since the automatic method using the IHD volume was less specific. CONCLUSION: The use of quantitative methods can improve performance in detection of perfusion asymmetry over visual inspection alone.
Document type :
Journal articles
Complete list of metadatas

Cited literature [24 references]  Display  Hide  Download
Contributor : Aurore Quentin <>
Submitted on : Monday, August 8, 2011 - 12:25:36 PM
Last modification on : Wednesday, November 25, 2020 - 6:44:05 PM
Long-term archiving on: : Wednesday, November 9, 2011 - 2:20:07 AM


  • HAL Id : inserm-00136496, version 1
  • PUBMED : 15809495


Bérengère Aubert-Broche, Pierre Jannin, Arnaud Biraben, Anne-Marie Bernard, Claire Haegelen, et al.. Evaluation of methods to detect interhemispheric asymmetry on cerebral perfusion SPECT: application to epilepsy.. Journal of Nuclear Medicine, Society of Nuclear Medicine, 2005, 46 (4), pp.707-13. ⟨inserm-00136496⟩



Record views


Files downloads