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Mechanism of viral persistence and resistance to nucleoside and nucleotide analogs in chronic Hepatitis B virus infection

Abstract : Chronic hepatitis B virus (HBV) infections remain a major problem public health problem worldwide, as well as a therapeutic challenge for clinicians. This review focuses on the main viral and host determinants involved in HBV persistence in infected cells. The mechanism of HBV resistance to nucleoside analogs are described as well as the concept for multiple drug therapy and combination with immunostimulatory approaches.
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https://www.hal.inserm.fr/inserm-00136413
Contributor : Fabien Zoulim <>
Submitted on : Friday, March 16, 2007 - 1:57:44 PM
Last modification on : Thursday, November 21, 2019 - 2:07:54 AM
Long-term archiving on: : Tuesday, April 6, 2010 - 9:52:55 PM

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  • HAL Id : inserm-00136413, version 1
  • PUBMED : 15451174

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Fabien Zoulim. Mechanism of viral persistence and resistance to nucleoside and nucleotide analogs in chronic Hepatitis B virus infection. Antiviral Research, Elsevier Masson, 2004, 64 (1), pp.1-15. ⟨inserm-00136413⟩

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