Skip to Main content Skip to Navigation
Journal articles

Reciprocal regulation of brain and muscle Arnt-like protein 1 and peroxisome proliferator-activated receptor alpha defines a novel positive feedback loop in the rodent liver circadian clock.

Abstract : Recent evidence has emerged that peroxisome proliferator-activated receptor alpha (PPARalpha), which is largely involved in lipid metabolism, can play an important role in connecting circadian biology and metabolism. In the present study, we investigated the mechanisms by which PPARalpha influences the pacemakers acting in the central clock located in the suprachiasmatic nucleus and in the peripheral oscillator of the liver. We demonstrate that PPARalpha plays a specific role in the peripheral circadian control because it is required to maintain the circadian rhythm of the master clock gene brain and muscle Arnt-like protein 1 (bmal1) in vivo. This regulation occurs via a direct binding of PPARalpha on a potential PPARalpha response element located in the bmal1 promoter. Reversely, BMAL1 is an upstream regulator of PPARalpha gene expression. We further demonstrate that fenofibrate induces circadian rhythm of clock gene expression in cell culture and up-regulates hepatic bmal1 in vivo. Together, these results provide evidence for an additional regulatory feedback loop involving BMAL1 and PPARalpha in peripheral clocks.
Document type :
Journal articles
Complete list of metadatas

https://www.hal.inserm.fr/inserm-00135943
Contributor : Ouria Dkhissi-Benyahya <>
Submitted on : Monday, March 19, 2007 - 10:59:23 AM
Last modification on : Saturday, May 30, 2020 - 11:20:00 PM
Long-term archiving on: : Tuesday, April 6, 2010 - 9:42:27 PM

Identifiers

Collections

Citation

Laurence Canaple, Juliette Rambaud, Ouria Dkhissi-Benyahya, Béatrice Rayet, Nguan Soon Tan, et al.. Reciprocal regulation of brain and muscle Arnt-like protein 1 and peroxisome proliferator-activated receptor alpha defines a novel positive feedback loop in the rodent liver circadian clock.. Mol Endocrinol, 2006, 20 (8), pp.1715-27. ⟨10.1210/me.2006-0052⟩. ⟨inserm-00135943⟩

Share

Metrics

Record views

503

Files downloads

424