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Compacting local protein folds with a Hybrid Protein: Compacting local protein folds

Abstract : The "Hybrid Protein Model" (HPM) is a fuzzy model for compacting local protein structures. It learns a non-redundant database encoded in a previously defined structural alphabet composed of 16 protein blocks (PBs). The hybrid protein is composed of a series of distributions of the probability of observing the PBs. The training is an iterative unsupervised process that for every fold to be learnt consists of looking for the most similar pattern present in the hybrid protein and modifying it slightly. Finally each position of the hybrid protein corresponds to a set of similar local structures. Superimposing those local structures yields an average root mean square of 3.14 Å. The significant amino acid characteristics related to the local structures are determined. The use of this model is illustrated by finding the most similar folds between two cytochromes P450.
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https://www.hal.inserm.fr/inserm-00132867
Contributor : Alexandre G. de Brevern <>
Submitted on : Monday, February 26, 2007 - 1:38:46 PM
Last modification on : Friday, March 27, 2020 - 2:59:54 AM
Long-term archiving on: : Friday, September 21, 2012 - 11:50:22 AM

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Alexandre de Brevern, Serge Hazout. Compacting local protein folds with a Hybrid Protein: Compacting local protein folds. Theoretical Chemistry Accounts: Theory, Computation, and Modeling, Springer Verlag, 2001, 106 (1/2), pp.36-47. ⟨10.1007/s002140000227⟩. ⟨inserm-00132867⟩

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