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Long-term outcome of children born after a first-trimester measurement of nuchal translucency at the 99th percentile or greater with normal karyotype: a prospective study.

Abstract : OBJECTIVE: This study was undertaken to assess the long-term outcome of children born after a first-trimester measurement of nuchal translucency (NT) at the 99th percentile or greater during routine first-trimester screening in an unselected population. STUDY DESIGN: One hundred sixty-two infants were born alive. Clinical examination as well as a questionnaire to the parents (Ages and Stages Questionnaires [ASQ]) at the age of 2 years were obtained in 160 children. Our study population was compared with an external control group made of the 370 term control children. RESULTS: The prevalence of abnormal clinical pediatric examination and ASQ results at 2 years were not associated with NT thickness. Comparison with an external control group did not demonstrate an increased incidence of developmental delay. CONCLUSION: Parents should be informed that when the fetus is shown to be normal by ultrasound at 22-24 weeks of gestation the risk of adverse neonatal outcome or developmental delay in early childhood is not increased.
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https://www.hal.inserm.fr/inserm-00131447
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Submitted on : Friday, February 16, 2007 - 2:59:38 PM
Last modification on : Wednesday, September 16, 2020 - 4:53:38 PM
Long-term archiving on: : Wednesday, April 7, 2010 - 2:47:16 AM

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Marie-Victoire Senat, Laurence Bussières, Sophie Couderc, Joelle Roume, Patrick Rozenberg, et al.. Long-term outcome of children born after a first-trimester measurement of nuchal translucency at the 99th percentile or greater with normal karyotype: a prospective study.. American Journal of Obstetrics and Gynecology, Elsevier, 2007, 196 (1), pp.53.e1-6. ⟨10.1016/j.ajog.2006.08.026⟩. ⟨inserm-00131447⟩

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