F. Hatton, L. Tiret, L. Maujol, N. Doye, P. Vourc-'h et al., Enquête épidémiologique sur les accidents d'anesthésie. Premiers résultats, Ann Fr Anesth Reanim, vol.2, issue.5, pp.331-86, 1983.

K. Drader and I. Herrick, CAROTID ENDARTERECTOMY: MONITORING AND ITS EFFECT ON OUTCOME, Anesthesiology Clinics of North America, vol.15, issue.3
DOI : 10.1016/S0889-8537(05)70354-0

E. Mahla, The electroencephalogram in the operating room, Seminars in Anesthesia, Perioperative Medicine and Pain, vol.16, issue.1, pp.3-13, 1997.
DOI : 10.1016/S0277-0326(97)80003-7

P. Prior, The rationale and utility of neurophysiological investigations in clinical monitoring for brain and spinal cord ischaemia during surgery and intensive care, Computer Methods and Programs in Biomedicine, vol.51, issue.1-2, pp.13-27, 1996.
DOI : 10.1016/0169-2607(96)01759-2

J. Guerit, Neuromonitoring in the operating room: why, when, and how to monitor?, Electroencephalography and Clinical Neurophysiology, vol.106, issue.1
DOI : 10.1016/S0013-4694(97)00077-1

R. Bikford, Automatic electroencephalographic control of general anesthesia, Electroencephalography and Clinical Neurophysiology, vol.2, issue.1-4
DOI : 10.1016/0013-4694(50)90014-9

L. Herregods and G. Rolly, The EMG, the EEG zero crossing frequency and mean integrated voltage analysis during sleep and anesthesia

. Consciousness, Awareness and Pain in General Anesthesia. London: Butterworths; 1987, pp.83-91

L. Herregods, G. Rolly, C. Dutre, C. Mergaert, and E. Mortier, Quantitative evaluation of adequacy of clinical anesthesia ; personal experience with anesthesia and brain activity monitor, Memory and Awareness in Anesthesia: Swets and Zeitlinger, pp.365-70, 1990.

L. Couture, B. Greenwald, and H. Edmonds, Detection of responsiveness during anesthesia

P. Vijn and J. Sneyd, I.v. anaesthesia and EEG burst suppression in rats: bolus injections and closed-loop infusions., British Journal of Anaesthesia, vol.81, issue.3, pp.415-436, 1998.
DOI : 10.1093/bja/81.3.415

R. Bikford, J. Findeiss, G. Kien, K. Huse, and H. Linde, Use of frequency determination in the automatic electroencephalographic control of anesthesia (servoanesthesia) Power spectral density of the electroencephalogram during halothane and cyclopropane anesthesia in man, Electroencephalogr Clin Neurophysiol Anesth Analg, vol.348, issue.146, pp.83-61018, 1951.

A. Bart, J. Homi, H. Linde, N. Smith, I. Rampil et al., Changes in power spectra of electroencephalograms during anesthesia with fluroxene, methoxyflurane and ethrane EEG during rapidly changing halothane or enflurane, S4. 17. Levy WJ. Power spectrum correlates of changes in consciousness during anesthetic induction with enflurane, pp.53-63688, 1971.

I. Rampil, F. Sasse, M. Laster, N. Smith, B. Hoff et al., Spectral edge frequency-anew correlate of anesthetic depth Closed-loop feedback control of methohexital anesthesia by quantitative EEG analysis in humans, Anesthesiology Anesthesiology, vol.5367, issue.3, pp.341-348, 1980.

H. Stoeckel and H. Schwilden, Median EEG frequency

. Consciousness, Awareness and Pain in General Anesthesia: Butterworths; 1987, pp.53-60

N. Shah, J. Spydell, D. Desiderio, and R. Bedford, Processed EEG monitoring for preventing awareness during light isoflurane/fentanyl anesthesia, Memory and Awareness in Anesthesia: Swets and Zeitlinger, pp.378-81, 1990.

P. Withington, J. Morton, R. Arnold, P. Sebel, and R. Moberg, Assessment of power spectral edge for monitoring depth of anaesthesia using low methohexitone infusion, International Journal of Clinical Monitoring and Computing, vol.56, issue.2, pp.117-139, 1986.
DOI : 10.1007/BF01880764

C. Thomsen, A. Rosenfalck, N. Christensen, and K. , Assessment of anaesthetic depth by clustering analysis and autoregressive modelling of electroencephalograms, Computer Methods and Programs in Biomedicine, vol.34, issue.2-3, pp.2-3125, 1991.
DOI : 10.1016/0169-2607(91)90038-U

I. Rampil and M. Laster, No Correlation between Quantitative Electroencephalographic Measurements and Movement Response to Noxious Stimuli during Isoflurane Anesthesia in Rats, Anesthesiology, vol.77, issue.5
DOI : 10.1097/00000542-199211000-00014

R. Dwyer, I. Rampil, E. Eger, and H. Bennett, The Electroencephalogram Does Not Predict Depth of Isoflurane Anesthesia, Anesthesiology, vol.81, issue.2, pp.403-412, 1994.
DOI : 10.1097/00000542-199408000-00019

P. Sebel, J. Bovill, A. Wauquier, and R. P. , Effects of High-dose Fentanyl Anesthesia on the Electroencephalogram, Anesthesiology, vol.55, issue.3, pp.203-214, 1981.
DOI : 10.1097/00000542-198109000-00004

J. Bovill, P. Sebel, A. Wauquier, and R. P. , ELECTROENCEPHALOGRAPHIC EFFECTS OF SUFENTANIL ANAESTHESIA IN MAN, BJA: British Journal of Anaesthesia, vol.54, issue.1, pp.45-52, 1982.
DOI : 10.1093/bja/54.1.45

Y. Amaki, T. Horiguchi, and K. Kobayashi, EEG analysis of effetiveness of the benzodiazepine-antogonist flyumazenil after diazepam sedation, Memory and Awareness in Anesthesia. msterdam: Swets and Zeitlinger, pp.286-293, 1990.

H. Traast and C. Kalkman, Electroencephalographic characteristics of emergence from propofol/sufentanil total intravenous anesthesia, Anesth Analg, vol.81, issue.2, pp.366-71, 1995.

J. Mcewen, G. Anderson, M. Low, and L. Jenkins, Monitoring the Level of Anesthesia by Automatic Analysis of Spontaneous EEG Activity, IEEE Transactions on Biomedical Engineering, vol.22, issue.4, pp.299-305, 1975.
DOI : 10.1109/TBME.1975.324448

R. Dutton, W. Smith, and N. Smith, A532 DOES THE EEG PREDICT ANESTHETIC DEPTH BETTER THAN CARDIOVASCULAR VARIABLES?, Anesthesiology, vol.73, issue.Supplement, p.535, 1990.
DOI : 10.1097/00000542-199009001-00530

R. Veselis, R. Reinsel, and M. Wronski, Analytical methods to differentiate similar electroencephalographic spectra: neural network and discriminant analysis, Journal of Clinical Monitoring, vol.76, issue.4, pp.257-67, 1993.
DOI : 10.1007/BF02886696

T. Ning and J. Bronzino, Bispectral analysis of the rat EEG during various vigilance states, IEEE Transactions on Biomedical Engineering, vol.36, issue.4, pp.497-506, 1989.
DOI : 10.1109/10.18759

I. Rampil, A Primer for EEG Signal Processing in Anesthesia, Anesthesiology, vol.89, issue.4, pp.980-1002, 1998.
DOI : 10.1097/00000542-199810000-00023

L. Kearse, J. Manberg, P. Chamoun, N. , F. Zaslavsky et al., Bispectral Analysis of the Electroencephalogram Correlates with Patient Movement to Skin Incision during Propofol/Nitrous Oxide Anesthesia, Anesthesiology, vol.81, issue.6, pp.1365-70, 1994.
DOI : 10.1097/00000542-199412000-00010

P. Sebel, S. Bowles, V. Saini, and N. Chamoun, Eeg bispectrum predicts movement during thiopental/isoflurane anesthesia, Journal of Clinical Monitoring, vol.68, issue.2, pp.83-91, 1995.
DOI : 10.1007/BF01617729

L. Kearse, J. Manberg, P. Debros, F. Chamoun, N. Sinai et al., Bispectral analysis of the electroencephalogram during induction of anesthesia may predict hemodynamic responses to laryngoscopy and intubation, Electroencephalography and Clinical Neurophysiology, vol.90, issue.3, pp.194-200, 1994.
DOI : 10.1016/0013-4694(94)90091-4

J. Vernon, E. Lang, P. Sebel, and P. Manberg, Prediction of movement using bispectral electroencephalographic analysis during propofol/alfentanil or isoflurane/alfentanil anesthesia, Anesth Analg, vol.80, issue.4, pp.780-785, 1995.

P. Sebel, E. Lang, I. Rampil, P. White, R. Cork et al., A Multicenter Study of Bispectral Electroencephalogram Analysis for Monitoring Anesthetic Effect, Anesthesia & Analgesia, vol.84, issue.4, pp.891-900, 1997.
DOI : 10.1213/00000539-199704000-00035

T. Katoh, A. Suzuki, and K. Ikeda, Electroencephalographic Derivatives as a Tool for Predicting the Depth of Sedation and Anesthesia Induced by Sevoflurane, Anesthesiology, vol.88, issue.3, pp.642-50, 1998.
DOI : 10.1097/00000542-199803000-00014

P. Glass, M. Bloom, L. Kearse, C. Rosow, P. Sebel et al., Bispectral analysis measures sedation and memory effects of propofol, midazolam, isoflurane, and alfentanil in healthy volunteers Titration of volatile anesthetics using bispectral index facilitates recovery after ambulatory anesthesia, Anesthesiology Anesthesiology, vol.8687, issue.44, pp.836-47842, 1997.

G. Barr, J. Jakobsson, A. Owall, and R. Anderson, Nitrous oxide does not alter bispectral index: study with nitrous oxide as sole agent and as an adjunct to i.v. anaesthesia, British Journal of Anaesthesia, vol.82, issue.6, pp.827-857, 1999.
DOI : 10.1093/bja/82.6.827

J. Muthuswamy and R. Roy, The use of fuzzy integrals and bispectral analysis of the electroencephalogram to predict movement under anesthesia, IEEE Transactions on Biomedical Engineering, vol.46, issue.3, pp.291-300, 1999.
DOI : 10.1109/10.748982

T. Allison, W. Goff, W. Lyons, T. Fisher, C. Thornton et al., Origin of early auditory evoked potentials in mans : effects of barbiturate anesthesia Effect of etomidate on the auditory evoked response in man, Electroencephalogr Clin Neurophysiol Br J Anaesth, vol.3157, issue.6, pp.451-47554, 1971.

C. Thornton, C. Heneghan, M. Navaratnarajah, and J. Jones, SELECTIVE EFFECT OF ALTHESIN ON THE AUDITORY EVOKED RESPONSE IN MAN, BJA: British Journal of Anaesthesia, vol.58, issue.4, pp.422-429, 1986.
DOI : 10.1093/bja/58.4.422

D. Chassard, A. Joubaud, A. Colson, M. Guiraud, C. Dubreuil et al., AUDITORY EVOKED POTENTIALS DURING PROPOFOL ANAESTHESIA IN MAN, BJA: British Journal of Anaesthesia, vol.62, issue.5, pp.522-528, 1989.
DOI : 10.1093/bja/62.5.522

D. Schwender, T. Rimkus, R. Haessler, S. Klasing, E. Poppel et al., EFFECTS OF INCREASING DOSES OF ALFENTANIL, FENTANYL AND MORPHINE ON MID-LATENCY AUDITORY EVOKED POTENTIALS, BJA: British Journal of Anaesthesia, vol.71, issue.5, pp.622-630, 1993.
DOI : 10.1093/bja/71.5.622

J. Mark and L. Greenberg, Intraoperative Awareness and Hypertensive Crisis during High-Dose Fentanyl-Diazepam-Oxygen Anesthesia, Anesthesia & Analgesia, vol.62, issue.7, pp.698-700, 1983.
DOI : 10.1213/00000539-198307000-00014

C. Thornton, D. Catley, C. Jordan, J. Lehane, D. Royston et al., ENFLURANE ANAESTHESIA CAUSES GRADED CHANGES IN THE BRAINSTEM AND EARLY CORTICAL AUDITORY EVOKED RESPONSE IN MAN, BJA: British Journal of Anaesthesia, vol.55, issue.6, pp.479-86, 1983.
DOI : 10.1093/bja/55.6.479

C. Thornton, C. Heneghan, M. James, J. Jones, C. Heneghan et al., Effects of halothane or enflurane with controlled ventilation on auditory evoked potentials Effect of isoflurane on the auditory evoked response in man, Br J Anaesth Br J Anaesth, vol.5659, issue.543, pp.315-23277, 1984.

C. Madler, I. Keller, D. Schwender, and E. Poppel, SENSORY INFORMATION PROCESSING DURING GENERAL ANAESTHESIA: EFFECT OF ISOFLURANE ON AUDITORY EVOKED NEURONAL OSCILLATIONS, BJA: British Journal of Anaesthesia, vol.66, issue.1, pp.81-88, 1991.
DOI : 10.1093/bja/66.1.81

M. Doi, R. Gajraj, H. Mantzaridis, and G. Kenny, Prediction of movement at laryngeal mask airway insertion: comparison of auditory evoked potential index, bispectral index, spectral edge frequency and median frequency., British Journal of Anaesthesia, vol.82, issue.2, pp.203-210, 1999.
DOI : 10.1093/bja/82.2.203

F. Davies, H. Mantzaridis, G. Kenny, and A. Fisher, Middle latency auditory evoked potentials during repeated transitions from consciousness to unconsciousness, Anaesthesia, vol.49, issue.2, pp.107-120, 1996.
DOI : 10.1016/0013-4694(74)90155-2

H. Mantzaridis and G. Kenny, Auditory evoked potential index: a quantitative measure of changes in auditory evoked potentials during general anaesthesia, Anaesthesia, vol.52, issue.11, pp.1030-1036, 1997.
DOI : 10.1111/j.1365-2044.1997.185-az0327.x

R. Gajraj, M. Doi, H. Mantzaridis, and G. Kenny, Analysis of the EEG bispectrum, auditory evoked potentials and the EEG power spectrum during repeated transitions from consciousness to unconsciousness, British Journal of Anaesthesia, vol.80, issue.1, pp.46-52, 1998.
DOI : 10.1093/bja/80.1.46

R. Gajraj, M. Doi, H. Mantzaridis, and G. Kenny, Comparison of bispectral EEG analysis and auditory evoked potentials for monitoring depth of anaesthesia during propofol anaesthesia, British Journal of Anaesthesia, vol.82, issue.5, pp.672-680, 1999.
DOI : 10.1093/bja/82.5.672

J. Huang, Y. Lu, A. Nayak, and R. Roy, Depth of anesthesia estimation and control

S. Akselrod, D. Gordon, F. Ubel, D. Shannon, A. Berger et al., Power spectrum analysis of heart rate fluctuation: a quantitative probe of beat-to-beat cardiovascular control, Science, vol.213, issue.4504, pp.220-222, 1981.
DOI : 10.1126/science.6166045

A. Malliani, M. Pagani, F. Lombardi, and S. Cerutti, Cardiovascular neural regulation explored in the frequency domain, Circulation, vol.84, issue.2, pp.482-92, 1991.
DOI : 10.1161/01.CIR.84.2.482

N. Ireland, J. Meagher, J. Sleigh, and J. Henderson, Heart rate variability in patients recovering from general anaesthesia, British Journal of Anaesthesia, vol.76, issue.5, pp.657-62, 1996.
DOI : 10.1093/bja/76.5.657

D. Galletly, A. Westenberg, B. Robinson, and T. Corfiatis, Effect of halothane, isoflurane and fentanyl on spectral components of heart rate variability, BJA: British Journal of Anaesthesia, vol.72, issue.2, pp.177-80, 1994.
DOI : 10.1093/bja/72.2.177

M. Kato, T. Komatsu, T. Kimura, F. Sugiyama, K. Nakashima et al., Spectral Analysis of Heart Rate Variability during Isoflurane Anesthesia, Anesthesiology, vol.77, issue.4, pp.669-74, 1992.
DOI : 10.1097/00000542-199210000-00009

M. Kawamoto, K. Kaneko, . Hardian, and O. Yuge, Heart rate variability during artificial ventilation and apnea in brain-damaged rabbits, Am J Physiol, vol.271, issue.2 2, pp.410-416, 1996.

A. Schubert, J. Palazzolo, J. Brum, M. Ribeiro, and M. Tan, Heart rate, heart rate variability, and blood pressure during perioperative stressor events in abdominal surgery, Journal of Clinical Anesthesia, vol.9, issue.1, pp.52-60, 1997.
DOI : 10.1016/S0952-8180(96)00208-5

Y. Donchin, J. Feld, and S. Porges, Respiratory Sinus Arrhythmia during Recovery from Isoflurane???Nitrous Oxide Anesthesia, Anesthesia & Analgesia, vol.64, issue.8, pp.811-816, 1985.
DOI : 10.1213/00000539-198508000-00012

C. Deutschman, A. Harris, and L. Fleisher, Changes in Heart Rate Variability Under Propofol Anesthesia, Anesthesia & Analgesia, vol.79, issue.2, pp.373-380, 1994.
DOI : 10.1213/00000539-199408000-00031

A. Yli-hankala and V. Jantti, EEG burst-suppression pattern correlates with the instantaneous heart rate under isoflurane anaesthesia, Acta Anaesthesiologica Scandinavica, vol.59, issue.8, pp.665-673, 1990.
DOI : 10.1111/j.1399-6576.1990.tb03169.x

A. Yli-hankala, H. Heikkila, A. Varri, and V. Jantti, Correlation between EEG and heart rate variation in deep enflurane anaesthesia, Acta Anaesthesiologica Scandinavica, vol.75, issue.2, pp.138-181, 1990.
DOI : 10.1111/j.1399-6576.1990.tb03058.x

A. Yli-hankala, P. Loula, P. Annila, L. Lindgren, V. Jantti et al., Atropine abolishes electroencephalogram-associated heart rate changes without an effect on respiratory sinus arrhythmia during anaesthesia in humans Comparison of bispectral index, 95% spectral edge frequency and approximate entropy of the EEG, with changes in heart rate variability during induction of general anaesthesia, Acta Physiol Scand Br J Anaesth, vol.14982, issue.45, pp.435-40666, 1993.

H. F. Bennett, E : a sensitive and specific monitor for the adequacy ('depth') of anesthesia, Memory and Awareness in Anesthesia, pp.249-254, 1993.

J. Evans, J. Bithell, and I. Vlachonikolis, RELATIONSHIP BETWEEN LOWER OESOPHAGEAL CONTRACTILITY, CLINICAL SIGNS AND HALOTHANE CONCENTRATION DURING GENERAL ANAESTHESIA AND SURGERY IN MAN, BJA: British Journal of Anaesthesia, vol.59, issue.11, pp.1346-55, 1987.
DOI : 10.1093/bja/59.11.1346

P. Cox and D. White, Do esophageal concentrations measure 'depth' of anesthesia?, Br J Anaesth, vol.58, pp.131-132, 1986.

J. Coatrieux, Issues on signal processing and physiological modeling. Part II: Depth model-driven analysis Waltz E, Buede D. Data fusion and decision support for command and control, Crit Rev Biomed Eng IEEE Trans Syst Man Cybern, vol.8216, pp.865-79, 1986.

R. Luo and M. Kay, Multisensor integration and fusion in intelligent systems, IEEE Transactions on Systems, Man, and Cybernetics, vol.19, issue.5, pp.901-932, 1989.
DOI : 10.1109/21.44007

B. Dasarathy, Decision fusion strategies in multisensor environments, IEEE Transactions on Systems, Man, and Cybernetics, vol.21, issue.5, pp.1140-54, 1991.
DOI : 10.1109/21.120065

S. Isaka and A. Sebald, Control strategies for arterial blood pressure regulation, IEEE Transactions on Biomedical Engineering, vol.40, issue.4, pp.353-63, 1993.
DOI : 10.1109/10.222328

C. Yu, R. Roy, H. Kaufman, and B. Bequette, Multiple-model adaptive predictive control of mean arterial pressure and cardiac output, IEEE Transactions on Biomedical Engineering, vol.39, issue.8, pp.765-78, 1992.
DOI : 10.1109/10.148385

G. Voss, P. Katona, and H. Chizeck, Adaptive multivariable drug delivery: control of arterial pressure and cardiac output in anesthetized dogs, IEEE Trans Biomed Eng, vol.34, issue.8, pp.617-640, 1987.

G. Kenny and M. White, A portable computerised infusion system for propofol

R. Rao, B. Bequette, and R. Roy, Simultaneous Regulation of Hemodynamic and Anesthetic States: A Simulation Study, Annals of Biomedical Engineering, vol.28, issue.1, pp.71-84, 2000.
DOI : 10.1114/1.255

P. Friederich and B. Urban, Multitasked closed-loop control in anesthesia Interaction of intravenous anesthetics with human neuronal potassium currents in relation to clinical concentrations, IEEE Eng Med Biol Mag Anesthesiology, vol.2091, issue.92, pp.39-531853, 1999.

P. Cariani, Anesthesia, Neural Information Processing, and Conscious Awareness, Consciousness and Cognition, vol.9, issue.3
DOI : 10.1006/ccog.1999.0420

S. Bjorkman, D. Wada, and D. Stanski, Application of Physiologic Models to Predict the Influence of Changes in Body Composition and Blood Flows on the Pharmacokinetics of Fentanyl and Alfentanil in Patients, Anesthesiology, vol.88, issue.3, pp.657-67, 1998.
DOI : 10.1097/00000542-199803000-00016

A. Bardou, P. Auger, P. Birkui, and J. Chasse, Modeling of Cardiac Electrophysiological Mechanisms: From Action Potential Genesis to its Propagation in Myocardium, Critical Reviews?? in Biomedical Engineering, vol.24, issue.2-3, pp.141-221, 1996.
DOI : 10.1615/CritRevBiomedEng.v24.i2-3.20

F. Wendling, J. Bellanger, F. Bartolomei, and P. Chauvel, Relevance of nonlinear lumped-parameter models in the analysis of depth-EEG epileptic signals, Biological Cybernetics, vol.83, issue.4, pp.367-78, 2000.
DOI : 10.1007/s004220000160